DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Upf1 and CG7504

DIOPT Version :9

Sequence 1:	NP_001285145.1	Gene:	Upf1 / 32153	FlyBaseID:	FBgn0030354	Length:	1180	Species:	Drosophila melanogaster
Sequence 2:	NP_001137907.1	Gene:	CG7504 / 38904	FlyBaseID:	FBgn0035842	Length:	1676	Species:	Drosophila melanogaster

Alignment Length:	793	Identity:	215/793 - (27%)
Similarity:	335/793 - (42%)	Gaps:	178/793 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   218 WLVKQPSEQGQLRARQISAAQINKLEELWKE--NIEATF-QDLEKPGIDSEPAHVLLRYEDGYQY 279
            |:.::......:|....|   |.|....|.:  :::|.. ||:..| |..|       ::....|
  Fly   956 WIRRENKPVNDIRQHSRS---ILKWANQWLKHGSVDAVAEQDVLMP-IPPE-------FDSFKNY 1009

  Fly   280 EKTFGPLVRLE----AEYDQKLKE----SATQENIEV-----RWDVGLNKKTIAYFTL--AKTDS 329
            .:.|.||::||    .|.|.|:..    |.:..|:|.     |....:|.|....|.|  .....
  Fly  1010 REIFVPLMKLELLSTIERDYKINNKNTFSVSLINVETQDMCYRLVTRVNSKPFGKFVLYTLYCCG 1074

  Fly   330 DMKLMHGDELRLHYV-GELYNPWSEIGHVIKVPDNFGDDVGLELKSSTNAPVKCTSNFTVDFIWK 393
            .:|....:.|.|.:| |.:::...||     :..:..::....:|..|..||  ..:..|:....
  Fly  1075 MLKETFANLLELKFVSGNVFDLTFEI-----LKQDISEEKLKNIKQLTARPV--VDSLRVELGAL 1132

  Fly   394 CTSFDRMTRALCKFAIDRNSVSNFIYSRLLGHGRADSNDEVLFRGPQPKLFSAPHLPDLNRSQVY 458
            .......:..||:..:......|                ||.. ..||..|...|  .||..|..
  Fly  1133 SAVHQLRSSPLCRRILKPTQTVN----------------EVSL-PKQPFTFKGCH--KLNEHQEN 1178

  Fly   459 AVKHALQR-------PLSLIQGPPGTGKTVTSATIVYQLVKLHGGT-------VLVCAPSNTAVD 509
            .|.|..||       .|:||||||||||:...:.:..|  .|:|..       :|:||.||||||
  Fly  1179 IVLHTYQRIIDDLQPSLTLIQGPPGTGKSRVISELCLQ--TLYGNAAKTLDRKILICAHSNTAVD 1241

  Fly   510 QLT-------EKIHRTNLKVVRVCAKSREA-IDSPVSFLALHNQIRNM------ETNSELKK--- 557
            .:.       ..::|....::|.....:.: ...|.|..|..|:.:..      :.|:|:.|
  Fly  1242 HIVGLLGSVLRVMNRDQFHLLRFGMHEKMSHYSRPFSLEAHFNKAKEQKLQRVSKENAEILKKQH 1306

  Fly   558 ------LQQLKDETGELSS-------ADEKRYRNLKRAAENQL----------------LEAADV 593
                  :||||::|...|:       ..||:.:.:    .|||                :..|::
  Fly  1307 NDLKDEIQQLKEKTNLTSTYLLQQLQQKEKKLQLI----SNQLSPPLTQREEFEISHMCVTRANI 1367

  Fly   594 ICCT---CVGAGDGRLSR-VKFTSI-LIDESMQSTEPECMVPVVLGAKQLILVGDHCQLGPVVMC 653
            ||.|   ||     :|:. |.|..| ::||:.|.|||..::|:..|...::||||..||..||:.
  Fly  1368 ICTTLSSCV-----KLANYVDFFDICIVDEATQCTEPWTLLPMRFGLTHMVLVGDMQQLPAVVLS 1427

  Fly   654 KKAARAGLSQSLFERLV--------------VLGIRPFRLEVQYRMHPELSQFPSNFFYEGSLQN 704
            |||...|||.|:|:|:.              ::..:.|:|..|||||||:.::|:.:|||..|.|
  Fly  1428 KKAIDFGLSNSMFDRIQRSLQTQLDKPGSYHLMHTKLFKLSTQYRMHPEICRWPNQYFYEDQLIN 1492

  Fly   705 GVCAEDRRLKLDFPWPQPERPMFFLVTQGQEEIAGSGT---SFLNRTEAANVEKITTRFLK-AGI 765
            ..|..        .:..|..|  :.|...:.....:|.   |..|..||..|.|:.|...| ...
  Fly  1493 AECTA--------RFASPLIP--YCVINLKYTCDSNGAQNKSISNNEEARFVAKLLTEMDKHMPS 1547

  Fly   766 KPEQIGIITPYEGQRAYLVQYMQYQGSLHSRLYQEIEIASVDAFQGREKDIIIMSCVRSNERQGI 830
            |....|:|:||:.|...|.|.:.        .:..|...:||::||.|||:||:|..|:   :|.
  Fly  1548 KRFSYGLISPYQNQCYALSQVIP--------SHMNITPQTVDSYQGLEKDVIIISNART---RGC 1601

  Fly   831 GFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLNFYKDRKV---LVEGSLNNLKESLIH 892
            |||.:.:||||||||.:..::|.||.:.|...::|.:||:..:.|||   |....:|:|..|||
  Fly  1602 GFLTNYQRLNVALTRPRRCLVICGNFEDLKSVEMWRNLLDDARKRKVYFNLDRDDVNDLDRSLI- 1665

  Fly   893 FQKPKKLVNSMNI 905
               .|.:||::|:
  Fly  1666 ---KKMMVNTINL 1675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500	6/32 (19%)
		DNA2	122..897	CDD:224037	211/783 (27%)
		Mis12	210..299	CDD:283509	21/87 (24%)
		AAA_19	458..>515	CDD:289986	27/77 (35%)
		AAA_12	661..857	CDD:289832	68/213 (32%)
CG7504	NP_001137907.1	FHA	4..96	CDD:238017
		FHA	<10..101	CDD:224630
		AAA_11	1171..1428	CDD:289831	76/267 (28%)
		AAA_19	1194..1251	CDD:289986	23/58 (40%)
		YtxH	<1293..1347	CDD:295162	14/57 (25%)
		AAA_12	1435..1626	CDD:289832	66/211 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438967
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D62494at2759
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10887
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850