Protein Alignment Upf1 and IGHMBP2

DIOPT Version :10

• Sequence 1: NP_572767.1
• Gene: Upf1 / 32153
• FlyBaseID: FBgn0030354
• Length: 1180
• Species: Drosophila melanogaster
• Sequence 2: NP_002171.2
• Gene: IGHMBP2 / 3508
• HGNCID: 5542
• Length: 993
• Species: Homo sapiens
• Alignment Length: 760
• Identity: 225/760 - (29%)
• Similarity: 322/760 - (42%)
• Gaps: 147/760 - (19%)

  Fly   289 LEAEYDQKLKESAT-QENIEVRWDVGLNKKTIAYFTLAKTDSDMKLMHGDELRLHYVGELYNPWS 352
            ||.|.|.:::|..: ||||.::   .|..:.:....| :..|....::| .|.:.:....|
Human    17 LELERDAEVEERRSWQENISLK---ELQSRGVCLLKL-QVSSQRTGLYG-RLLVTFEPRRY---- 72

  Fly   353 EIGHVIKVPDN---FGDDVGLE-------------LKSSTNAPVKCTSNFTVDFIWKCTSFDR-M 400
              |....:|.|   .||.|||.             |...|...|....:.:.||   ..|.|| .
Human    73 --GSAAALPSNSFTSGDIVGLYDAANEGSQLATGILTRVTQKSVTVAFDESHDF---QLSLDREN 132

  Fly   401 TRALCKFAID---RNSVSNFIYSRLLGHGRADSNDEVLFRGPQPKLFSAPHLP------DLNRSQ 456
            :..|.|.|.|   |......|..:....|.|.|..||||....|...|..| |      .|:.||
Human   133 SYRLLKLANDVTYRRLKKALIALKKYHSGPASSLIEVLFGRSAPSPASEIH-PLTFFNTCLDTSQ 196

  Fly   457 VYAVKHAL-QRPLSLIQGPPGTGKTVTSATIVYQLVKLHGGTVLVCAPSNTAVDQLTEKIHRTNL 520
            ..||..|| |:.|::|.||||||||.|...|:.|.|| .|..||.|||||.|||.|.|::.....
Human   197 KEAVLFALSQKELAIIHGPPGTGKTTTVVEIILQAVK-QGLKVLCCAPSNIAVDNLVERLALCKQ 260

  Fly   521 KVVR------------------VCAKS---------REAIDSPVSFLALHNQIRNMETNSELKKL 558
            :::|                  |.|:|         |:.||...        ::|.:|..:.:|
Human   261 RILRLGHPARLLESIQQHSLDAVLARSDSAQIVADIRKDIDQVF--------VKNKKTQDKREK- 316

  Fly   559 QQLKDETGELSSADEKRYRNLKRAAENQLLEAADVICCTCVGA-GDGRLSRVK---FTSILIDES 619
            ...::|...|    .|..:..:.||..:.|.:|:|:..|..|| .||.|..:.   |..::|||.
Human   317 SNFRNEIKLL----RKELKEREEAAMLESLTSANVVLATNTGASADGPLKLLPESYFDVVVIDEC 377

  Fly   620 MQSTEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAARAGLSQSLFERLV-VLGIRPFR-LEVQ 682
            .|:.|..|.:| :|.|::.||.|||.||.|..:..|||.||||.||.|||. ..|.|..| |.||
Human   378 AQALEASCWIP-LLKARKCILAGDHKQLPPTTVSHKAALAGLSLSLMERLAEEYGARVVRTLTVQ 441

  Fly   683 YRMHPELSQFPSNFFYEGSL--QNGVCAEDRRLKLDFP----WPQPERPMFFLVTQG-------Q 734
            ||||..:.::.|:..|.|.|  .:.|.   |.|..|.|    ..:...|:..:.|.|       :
Human   442 YRMHQAIMRWASDTMYLGQLTAHSSVA---RHLLRDLPGVAATEETGVPLLLVDTAGCGLFELEE 503

  Fly   735 EEIAGSGTSFLNRTEAANVEKITTRFLKAGIKPEQIGIITPYEGQRAYLVQYMQYQGSLHSRLYQ 799
            |:....|    |..|...|.......:.||:....|.:::||..|...|.|.:.::       :.
Human   504 EDEQSKG----NPGEVRLVSLHIQALVDAGVPARDIAVVSPYNLQVDLLRQSLVHR-------HP 557

  Fly   800 EIEIASVDAFQGREKDIIIMSCVRSNERQGIGFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQL 864
            |:||.|||.||||||:.:|:|.||||.:..:|||.:.||:|||:|||:..:.::.:.:.:.....
Human   558 ELEIKSVDGFQGREKEAVILSFVRSNRKGEVGFLAEDRRINVAVTRARRHVAVICDSRTVNNHAF 622

  Fly   865 WNHLLNF------------YKDRKVLVEGSLNNLKESLIHFQKPKKLVNSMNIGAHFMSTIIADA 917
            ...|:.:            |.|..|....|..|.:.|.....||:....|...|:....    ..
Human   623 LKTLVEYFTQHGEVRTAFEYLDDIVPENYSHENSQGSSHAATKPQGPATSTRTGSQRQE----GG 683

  Fly   918 KEVMVPGSIYDRSGGYGQGRQM-VGQSMNG---GQYGGSGGGPYG 958
            :|...|..         |||:. .|:|:..   .|...:||.|.|
Human   684 QEAAAPAR---------QGRKKPAGKSLASEAPSQPSLNGGSPEG 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_572767.1	UPF1_Zn_bind	98..249	CDD:401391
		1B_UPF1-like	302..390	CDD:394815	21/104 (20%)
		TIGR00376	355..880	CDD:273041	191/609 (31%)
		DEXXQc_UPF1	451..684	CDD:350797	96/266 (36%)
IGHMBP2	NP_002171.2	TIGR00376	19..641	CDD:273041	201/665 (30%)
		SS DNA-binding. /evidence=ECO:0000269|PubMed:8349627, ECO:0000305|PubMed:22999958	638..785		22/95 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	651..723		19/82 (23%)
		R3H_Smubp-2_like	726..784	CDD:100070
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	782..828
		PRK12438	<786..845	CDD:171499
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	841..879
		Nuclear localization signal. /evidence=ECO:0000255	864..868
		ZnF_AN1	902..937	CDD:197545
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	971..993