DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Upf1 and Mov10

DIOPT Version :9

Sequence 1:	NP_001285145.1	Gene:	Upf1 / 32153	FlyBaseID:	FBgn0030354	Length:	1180	Species:	Drosophila melanogaster
Sequence 2:	NP_001101181.1	Gene:	Mov10 / 310756	RGDID:	1598327	Length:	1004	Species:	Rattus norvegicus

Alignment Length:	900	Identity:	229/900 - (25%)
Similarity:	350/900 - (38%)	Gaps:	262/900 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 PGSSYVKELPPHACKYCGI----HDPATVVMCNNCRKWFCNGRGSTSGSHIINHLVRAKHREVTL 147
            ||.||  ||  |.  ||..    :.||||:       |...|.|. ||:.
  Rat   192 PGESY--EL--HV--YCKTSIVGYFPATVL-------WELLGPGE-SGAE--------------- 227

  Fly   148 HGEGPLGETILECYSCGVRNVFVLGFIPAKADSVVVL-------------LCRQPCAAQNSLKDM 199
                            |....::..|:.|.|.|.:..             |.|.|.:.....:..
  Rat   228 ----------------GAETFYIARFLAAVAHSPLAAQLKPTTPFKRPPRLTRNPVSTNRIEEGE 276

  Fly   200 NWDQEQ------------WKPLIADRCFLAWLVKQPS------EQGQLRARQISAAQINKLEELW 246
            ..|:.:            :.|.|..|..|..|::.||      |..:::|         :||...
  Rat   277 RPDRAKGYELELSLALGTYYPPIRLRQLLPTLLQGPSIFTSPKEVAEIKA---------QLETTL 332

  Fly   247 K-ENIEATFQDLEKPGIDSEPAHVLLRYEDGYQYEKTFGPLVRLEAEYDQKLKESATQENIEVRW 310
            | .|.|...:             :||..|:             |:.|:|.:..:   .|::.:.|
  Rat   333 KSRNYEVKLR-------------LLLHLEE-------------LQMEHDIRHYD---LESVPMTW 368

  Fly   311 D-VGLNKKTIAYFTLAKTDSDMKLMHGDELRLHYVGELY--NPWSEIGHVIKVPDNFGDDVGLEL 372
            | |..|.:.:.......|:|...::.||.|......|:.  :|.:..|.|.||.   .|.|.|..
  Rat   369 DPVDQNPRLLTLEVPGVTESRPSVLRGDHLFALLSSEIQQEDPVTYKGFVHKVE---LDRVKLSF 430

  Fly   373 KSSTNAPVKCTSNFTVDFIWKCTSFDRMTRAL----------CKFAIDRNSVSNF-------IYS 420
            ..|..:.......|.|:|.:.........|||          ..|.:....||..       :|.
  Rat   431 SPSLLSRFVDGLTFKVNFTFNRQPLRVQHRALELTGRWVLWPTLFPVASRGVSLLPSDVKFKLYD 495

  Fly   421 RLLGHGRADSNDEVLFRGPQPKLFSAPHLPDLNRSQVYAVKHALQ---RPLS-LIQGPPGTGKTV 481
            |.|     :||.|                      |:.|:||.::   ||.. :|.|||||||||
  Rat   496 RSL-----ESNPE----------------------QLQAMKHIVRGTTRPAPYIIFGPPGTGKTV 533

  Fly   482 TSATIVYQLVK-LHGGTVLVCAPSNTAVDQLTEKIHRTNL--KVVRVCAKSREAIDSPVSFLALH 543
            |....:.|:|| |....:|.|.|||:..|.|.::: |.:|  .:.|:.|.||:
  Rat   534 TLVEAIKQVVKHLPKAHILACTPSNSGADLLCQRL-RVHLPSSIYRLLAPSRD------------ 585

  Fly   544 NQIRNMETNSELKKLQQLKDETGELSSADEKRYRNLKRAAENQLLEAADVICCTCVGAGDGRLSR 608
                          ::.:.::.....:.|.|:...:..|.::  |:...|:..|.:.|  .||..
  Rat   586 --------------IRMVPEDIKTCCNWDPKKGEYVYPAKKH--LQQYRVLITTLITA--SRLVS 632

  Fly   609 VK-----FTSILIDESMQSTEPECMVPV--VLGAK-------QLILVGDHCQLGPVVMCKKAARA 659
            .:     ||.|.|||:....|||.:|.:  ::..|       ||:|.||..|||||:....|.:.
  Rat   633 AQFPIDHFTHIFIDEAGHCMEPESLVAIAGLMDVKETGNPGGQLVLAGDPRQLGPVLRSPLAQKH 697

  Fly   660 GLSQSLFERLVVL---------GIRP---FRLEVQYRMHPELSQFPSNFFYEGSLQNGVCAEDRR 712
            ||..||.|||:..         |..|   .:|...||.||.:...|:..:|:|.||  .||:...
  Rat   698 GLGYSLLERLLTYNSLYKKGPNGYDPQFITKLLRNYRSHPTILDIPNQLYYDGELQ--ACADVVD 760

  Fly   713 LKLDFPW---PQPERPMFFLVTQGQEEIAGSGTSFLNRTEAANVEKITTRFL-------KAGIKP 767
            .:....|   ||...|:.|....|::|..|:..||.|..|||.|.....:.|       ||.:.|
  Rat   761 RERFCRWEGLPQQGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLRQLLAPSSKKGKARLSP 825

  Fly   768 EQIGIITPYEGQRAYLVQYMQY-QGSLHSRL-----YQEIEIASVDAFQGREKDIIIMSCVRSNE 826
            ..:|:|:||..|    |:.::| ...|...|     .:::::.||:.|||:|:.:|::|.|||::
  Rat   826 RSVGVISPYRKQ----VEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQ 886

  Fly   827 R-------QGIGFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLNFYKD 874
            .       ..:|||.:|:|.|||:||||..:|:||||.:|.....|...|.|.|:
  Rat   887 SFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKTFLEFCKE 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500	33/186 (18%)
		DNA2	122..897	CDD:224037	215/860 (25%)
		Mis12	210..299	CDD:283509	19/95 (20%)
		AAA_19	458..>515	CDD:289986	27/61 (44%)
		AAA_12	661..857	CDD:289832	75/230 (33%)
Mov10	NP_001101181.1	DEXXQc_Helz-like	499..734	CDD:350796	78/287 (27%)
Mov10	NP_001101181.1	SF1_C_Upf1	735..940	CDD:350195	69/210 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810