DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Upf1 and Helz2

DIOPT Version :9

Sequence 1:	NP_001285145.1	Gene:	Upf1 / 32153	FlyBaseID:	FBgn0030354	Length:	1180	Species:	Drosophila melanogaster
Sequence 2:	NP_001292205.1	Gene:	Helz2 / 296474	RGDID:	1306056	Length:	2944	Species:	Rattus norvegicus

Alignment Length:	930	Identity:	230/930 - (24%)
Similarity:	348/930 - (37%)	Gaps:	320/930 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 QEQWKPLIADRCFLAWLVKQPSEQGQLRARQISAAQINKLE------------------------ 243
            :|:|..:.|       |::   ||.:| :||...||:::..
  Rat  2067 EERWPEVAA-------LIQ---EQDKL-SRQREKAQVHQSRCGHFIEVAYELGSGDTLQVQLGSS 2120

  Fly   244 ----------ELWK--ENIEATFQDLEKPGIDSEPAHVLLRYEDGY----QYEKTFGPLVRLE-- 290
                      :||.  .......:.:|:|| |....||....:|.|    ||...:||...||
  Rat  2121 LQRGFLAPTLQLWTVVPGFSLCLEHMERPG-DCFSGHVHQPLQDQYLEVSQYSGVWGPRCALESL 2184

  Fly   291 ----AEYDQKLKESATQENIEVRWDVG--------------LNKKTI------AY---------F 322
                ||.|     |...:::.:.||..              |.:|.|      .|         .
  Rat  2185 MSAVAEND-----SIVLQDVHIYWDTSQEQLQGTFQLEAAFLQEKCINIHFGCCYLCIRLEGLPL 2244

  Fly   323 TLAKT---DSDMK------------LMHGDELRLHYVGELYNPWSE----------------IGH 356
            .||.:   .||:.            :.||  |...:..||...|.:                |.|
  Rat  2245 PLASSLPGPSDLGPFLNIDPNTYTWVAHG--LSGDWDHELAGDWDQECVDDRQEVPKQVHFFIHH 2307

  Fly   357 VI--KVPDNFGDDVGLELKSSTNAPVKCTSNFTVDFIWKCTSFDRMTRALCKFAIDRNSVSNFIY 419
            :.  |||:..       |:.||        .|||:.:.|.....|...|:...    .:.|..:.
  Rat  2308 MTMEKVPEEV-------LRPST--------RFTVEVLSKQLPDLRKEEAVRGL----KNASPLVI 2353

  Fly   420 SRLLGHGRADSNDEVLFRGPQPK---------------LFSAPHLP------------------- 450
            |..||....:.:..:    |:|:               ..|.|.||
  Rat  2354 SIALGLPILEPHWPI----PEPRHQISWPRHQISWPRHPISGPCLPVSGLCLPVSGLCHPIPEPC 2414

  Fly   451 -------------------------------DLNRSQVYAVKHALQRPLSLIQGPPGTGKTVTSA 484
                                           .||:||..||:.|||:..::|||||||||||...
  Rat  2415 RRGWPPQHSSRKVPTSRFLERKNYNIPGGHHKLNQSQDKAVRSALQKQFTVIQGPPGTGKTVVGF 2479

  Fly   485 TIVY-----------------QLVKLHGGTVLVCAPSNTAVDQLTEKIHR--TNLKVVRVCAKSR 530
            .|||                 :..||.|..||.|.|||.:||.|...:.|  |.::.:||..:..
  Rat  2480 HIVYWFHRSNQEQMPTGSSPSEEEKLGGPCVLYCGPSNKSVDVLGGLLLRKKTEMRPLRVYGEQA 2544

  Fly   531 EAIDSP----------------------VSFLALHNQIRNMET--NSELKKLQ-QLKDETGELSS 570
            ||.:.|                      :..:.||::||....  .:|::|.. ||::  |::.|
  Rat  2545 EATEFPLPGVSNRSLFGKISQEGRPNQSLRSITLHHRIRQAPNPYAAEIRKFDAQLRE--GKIFS 2607

  Fly   571 ADEKR-YRNLKRAAENQLLEAADVICCTCVGAGDGRLSRVKFTSILIDESMQSTEPECMVPVVLG 634
            .|:.. ||.:...|....||...||.|||..|..|.|..:....|||||:..:||||.::|:|..
  Rat  2608 KDDLLVYRRVLGKARKYELERHSVILCTCSCAASGSLKALNVRQILIDEAGMATEPETLIPLVCF 2672

  Fly   635 AK--QLILVGDHCQLGPVVMCKKAARAGLSQSLFERLVVLGIRPFRLEVQYRMHPELSQFPSNFF 697
            :|  :::|:|||.||.|||..::....|:.:|||||.....|   .|:.|||||.::..|||..|
  Rat  2673 SKTEKVVLLGDHKQLRPVVKNEQLRNLGMDRSLFERYHRDAI---MLDTQYRMHKDICSFPSMEF 2734

  Fly   698 YEGSLQNGVCAEDRRLKLDFPWPQPER-------------PMFFLVTQGQEEIAGSGTSFLNRTE 749
            |.|.|:.              |...:|             |:.|...||.|:.....|...|...
  Rat  2735 YGGKLKT--------------WSDLKRPPSLLGHVGKQSCPVIFGSVQGYEQKLLVSTEEGNENS 2785

  Fly   750 AANVEKIT--TRFLK-----AGIKPEQIGIITPYEGQRAYLVQYMQYQGSLHSRLYQEIEIASVD 807
            .||.|::|  .|.:|     ..:.|:.:.::|||..|.|.:.:.:..:|      ...:.:.|:.
  Rat  2786 RANPEEVTEVVRIIKQLTLDRTVDPKDVAVLTPYNAQAAAISRGLMQRG------VTGVTVTSIT 2844

  Fly   808 AFQGREKDIIIMSCVRSNERQG-------------IGFLNDPRRLNVALTRAKFGIIIVGNPKVL 859
            ..||.|...:|:|.||:..|..             :||:.||.::|||:|||:.|:.|:|:..:|
  Rat  2845 KSQGSEWRYVIVSTVRTCPRSDMDQRPTKSWLKKFLGFVVDPHQVNVAITRAQEGLCIIGDHLLL 2909

  Fly   860 AKQQLWNHLLNFYKDRKVLV 879
            ....||:.||.|.:.:..||
  Rat  2910 RCCPLWHRLLGFCEAQNSLV 2929

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500	13/81 (16%)
		DNA2	122..897	CDD:224037	230/930 (25%)
		Mis12	210..299	CDD:283509	28/134 (21%)
		AAA_19	458..>515	CDD:289986	31/73 (42%)
		AAA_12	661..857	CDD:289832	63/228 (28%)
Helz2	NP_001292205.1	DEAD-like_helicase_N	759..989	CDD:421690
		AAA_12	961..1160	CDD:404073
		RNB	1565..1923	CDD:214935
		DEXXc_HELZ2-C	2446..2721	CDD:350798	96/279 (34%)
		AAA_12	2701..2906	CDD:404073	63/227 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910