DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Upf1 and Ighmbp2

DIOPT Version :9

Sequence 1:	NP_001285145.1	Gene:	Upf1 / 32153	FlyBaseID:	FBgn0030354	Length:	1180	Species:	Drosophila melanogaster
Sequence 2:	NP_113774.2	Gene:	Ighmbp2 / 29532	RGDID:	68325	Length:	988	Species:	Rattus norvegicus

Alignment Length:	959	Identity:	247/959 - (25%)
Similarity:	374/959 - (38%)	Gaps:	242/959 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 LEAEYDQKLKESAT-QENIEVRWDVGLNKKTIAYFTLAKTDSDMKLMHGDELRLHYVGELYNPWS 352
            ||.|.|.:::|..: ||:..::   .|..:.:....| :.......::|..|      ..:.| .
  Rat    17 LELERDAEVEERRSWQEHSSLK---ELQSRGVCLLKL-QVSGQRTGLYGQRL------VTFEP-R 70

  Fly   353 EIGHVIKVPDN---FGDDVGL-ELKSSTNAPVKCTSNFTVDFIWKCTSFDRM-----------TR 402
            :.|..:.:|.|   .||.||| :...|:.......:..|...:  ..:||..           |.
  Rat    71 KFGPAVVLPSNSFTSGDIVGLYDTNESSQLATGVLTRITQKSV--IVAFDESHDFQLNLDRENTY 133

  Fly   403 ALCKFAIDRNSVSNFIYSRL---------LGHGRADSNDEVLFRGPQPKLFSAPHLP-------D 451
            .|.|.|   |.|:   |.||         ...|.|.|..:||..|..|.  .|..:|       .
  Rat   134 RLLKLA---NDVT---YKRLKKALLTLKKYHSGPASSLIDVLLGGSTPS--PATEIPPLTFYNTT 190

  Fly   452 LNRSQVYAVKHAL-QRPLSLIQGPPGTGKTVTSATIVYQLVKLHGGTVLVCAPSNTAVDQLTEKI 515
            |:.||..||..|| |:.:::|.||||||||.|...|:.|.|| .|..||.|||||.|||.|.|::
  Rat   191 LDPSQKEAVSFALAQKEVAIIHGPPGTGKTTTVVEIILQAVK-QGLKVLCCAPSNIAVDNLVERL 254

  Fly   516 HRTNLKVVRVCAKSR--EAIDSPVSFLALHNQIRNMETNSELKKLQQLKDETGELSSADEKR--- 575
            .....:::|:...:|  |::... |..|:..:..|.:..:::::  .:....|:.....:||
  Rat   255 ALCKKQILRLGHPARLLESVQQH-SLDAVLARSDNAQIVADIRR--DIDQVFGKNKKTQDKREKS 316

  Fly   576 -YRN--------LK---RAAENQLLEAADVICCTCVGAG-DGRLSRVK---FTSILIDESMQSTE 624
             :||        ||   .||..|.|.||||:..|..||. ||.|..:.   |..:::||..|:.|
  Rat   317 NFRNEIKLLRKELKEREEAAIVQSLSAADVVLATNTGASTDGPLKLLPEDYFDVVVVDECAQALE 381

  Fly   625 PECMVPVVLGAKQLILVGDHCQLGPVVMCKKAARAGLSQSLFERLVVL-GIRPFR-LEVQYRMHP 687
            ..|.:| :|.|.:.||.|||.||.|..:..|||.||||:||.|||... |....| |.||||||.
  Rat   382 ASCWIP-LLKAPKCILAGDHKQLPPTTVSHKAALAGLSRSLMERLAEKHGAAVVRMLAVQYRMHQ 445

  Fly   688 ELSQFPSNFFYEGSLQNGVCAEDRRLKLDFP----WPQPERPMFFLVTQG-------QEEIAGSG 741
            .::::.|...|.|.|..........|| |.|    ..:...|:..:.|.|       :|:....|
  Rat   446 AITRWASEAMYHGQLTAHPSVAGHLLK-DLPGVADTEETSVPLLLIDTAGCGLLELEEEDSQSKG 509

  Fly   742 TSFLNRTEAANVEKITTRFLKAGIKPEQIGIITPYEGQRAYLVQYMQYQGSLHSRLYQEIEIASV 806
                |..|...|.......:.||::...|.:|.||..|...|.|.:       |..:.|:||.||
  Rat   510 ----NPGEVRLVTLHIQALVDAGVQAGDIAVIAPYNLQVDLLRQSL-------SNKHPELEIKSV 563

  Fly   807 DAFQGREKDIIIMSCVRSNERQGIGFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLNF 871
            |.||||||:.:|::.||||.:..:|||.:.||:|||:|||:..:.::.:          :|.:|.
  Rat   564 DGFQGREKEAVILTFVRSNRKGEVGFLAEDRRINVAVTRARRHVAVICD----------SHTVNN 618

  Fly   872 YKDRKVLVE-----GSLNN--------LKESLIH--------FQKPKKLVNSMNIGAHFMSTIIA 915
            :...|.||:     |.:..        :.|:..|        ..|||....|:.
  Rat   619 HAFLKTLVDYFTEHGEVRTAFEYLDDIVPENYTHEGSRSHSCAPKPKCPTTSVR----------- 672

  Fly   916 DAKEVMVPGSIYDRSGGYGQGRQMVGQSMNGGQYGGSGGGPYGNSPLGYGTPSSNSMVGFGLGNG 980
              |......|..:.....|..|:...:                 .|||......:|
  Rat   673 --KPASAQESRQEARAATGHSRRKPSE-----------------KPLGSQVQPQHS--------- 709

  Fly   981 GNGAAGGNNNFGGAGPSWAAAHLHHDSIGYISNEHGAAALGNMPVPVGMFMNMSNIPPRFYNQHQ 1045
              ..|.|::..||...:        :....:..|..|:....:..|..:            :.|.
  Rat   710 --SKANGSDRTGGTDRT--------EHFRAMIEEFVASKEAQLEFPTSL------------SSHD 752

  Fly  1046 QAIMAVKQNRAIQQQTGNFSPGNSGPGVTGVGVGRSATPGGNKKTNKLGKSRVTGGGTGGAPLTQ 1110
            :.        .:.|....|            |:...:|  |..|...:..||.:..|:|
  Rat   753 RL--------RVHQLAEEF------------GLKHDST--GEGKARHITVSRRSPAGSG------ 789

  Fly  1111 GSSVCNAAPYSQHPMPLSLQMTQPSGFALSQQPELSQDFGQ---ISQMD 1156
                 :|.|  |.|.|.|....:|       :|::.|..||   .:|:|
  Rat   790 -----SATP--QPPSPPSPAQAEP-------EPQVEQPVGQPHGSTQLD 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500
		DNA2	122..897	CDD:224037	205/695 (29%)
		Mis12	210..299	CDD:283509	4/9 (44%)
		AAA_19	458..>515	CDD:289986	32/57 (56%)
		AAA_12	661..857	CDD:289832	70/208 (34%)
Ighmbp2	NP_113774.2	TIGR00376	19..640	CDD:273041	200/668 (30%)
		SS DNA-binding. /evidence=ECO:0000250	637..783		29/228 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	651..722		17/111 (15%)
		R3H_Smubp-2_like	724..782	CDD:100070	10/99 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	765..820		18/76 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	835..872
		Nuclear localization signal. /evidence=ECO:0000255	857..861
		ZnF_AN1	890..930	CDD:197545
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	943..988
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810