Protein Alignment Upf1 and Setx

DIOPT Version :9

• Sequence 1: NP_001285145.1
• Gene: Upf1 / 32153
• FlyBaseID: FBgn0030354
• Length: 1180
• Species: Drosophila melanogaster
• Sequence 2: XP_006498142.1
• Gene: Setx / 269254
• MGIID: 2443480
• Length: 2701
• Species: Mus musculus
• Alignment Length: 1131
• Identity: 274/1131 - (24%)
• Similarity: 448/1131 - (39%)
• Gaps: 324/1131 - (28%)

  Fly     2 SVDTYAPSSALSFLDMDDNELLPGADTQPTQYDYRDFTMPSTSQSQTQNDQLEIAQRCSAGD--- 63
            ||....|:|: |..|.|||..|       ||:|.:|..:    .||.:|..:.:|.:.....
Mouse  1462 SVKAAEPASS-SDTDDDDNLFL-------TQHDPQDMDL----CSQLENKTIIVAHKKDTVQRED 1514

  Fly    64 --SHPRLASITNDLADLQFEEEDDEPGSSYVKELPPHACKYCGIHDPATVV-------------M 113
              |.|:|.|::  :...::::         ..|...:..:||..|..|...             :
Mouse  1515 SLSRPQLESLS--ITKCKYKD---------CVETTKNQGEYCPRHSEAKAADDGLFRKPGLPLSV 1568

  Fly   114 CNNCRKWFCNGRGSTSGSHIINHLVRAKHREVTLHGEGPLGETILECYSCGVR-NVFVLGFIPAK 177
            ....|........|:|.|...|   .:|..|.|     .|.::.|:..|.|.: |:.|..  |:.
Mouse  1569 ARPLRPTTTKIFSSSSASRTAN---LSKSLEST-----TLQQSALKNKSSGAQPNLKVTP--PSS 1623

  Fly   178 ADSVVVLLCRQPCAAQNSLKDMNWDQEQWKPLIADR--CFLAWLVKQPSEQGQLRARQISAAQIN 240
            ..|      ::|.|...||.::...|   .|..:.:  |.|.:...:|:.         :|:.:|
Mouse  1624 MGS------QKPVAEVKSLCNIFHFQ---TPSSSSKQSCKLTFSENRPTS---------AASPVN 1670

  Fly   241 KL------------EEL-WKENIEATF----------QDLEKPGIDSEPAHVLLRYEDGYQYEKT 282
            .|            |.| ||..:...|          |.:.:|        |.:|::|..:|...
Mouse  1671 ILLPSQSIFDTFIKEVLKWKYQMFLNFDKCGAPTSLCQSISRP--------VPVRFQDCAEYFNV 1727

  Fly   283 FGPLVRLEAEYDQKLKESATQENIEVRWDVGLNKKTIAYFTLAKTDSDMK-----LMHGDELRLH 342
            |.||:.|.|      .|:..||     |....||:......|.|..:|.|     |::.:|..|
Mouse  1728 FLPLIILNA------FETVAQE-----WLSSPNKENFYQLQLRKFPADYKKYWEFLIYLNESEL- 1780

  Fly   343 YVGELYNPWSEIGHVIKVPD-NFGDDVGLELKSSTNAPVKCTSNFTVDFIWKC--TSFDRMTRAL 404
             ..:|:...:::  |...|: ::.|..|::         .| |::...::.|.  ||..|..:|.
Mouse  1781 -AKQLHPKENDL--VFLAPEKSYMDRHGMQ---------DC-SHYYCGYVHKFRRTSVMRSGKAE 1832

  Fly   405 CKFAIDRN-----SVSN----FIYSRLLGHGR-------ADSNDEV--LFRGPQPKLFS------ 445
            |...|...     ||.|    .:.|.|:...|       ..|.:::  ....|.|..|.
Mouse  1833 CSLCIQTQDTLPASVKNLTRCIVISSLVTTQRKLKAMSLLSSRNQLARAVLNPNPMDFCTKDLLT 1897

  Fly   446 ------APHLPDLNRSQ------VYA-VKHALQ-RPLSLIQGPPGTGKTVTSATIVYQLV----- 491
                  ..:|.|.|..|      .|| |||:.. ..:.||.|||||||:.|...::|:|:
Mouse  1898 TTSERIVAYLKDFNEDQKKAIETAYAMVKHSPSVAKICLIHGPPGTGKSKTIVGLLYRLLTENQR 1962

  Fly   492 ----------KLHGGTVLVCAPSNTAVDQLTEKI----------------HRTNLKVVRVCAKSR 530
                      |:....||||||||.|||:|.:||                :..::.:||:  ...
Mouse  1963 KGHSDENFNAKIKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNCGDINLVRL--GPE 2025

  Fly   531 EAIDSPVSFLALHNQIRN---METNSELKKLQQLKD----ETGELS---------------SADE 573
            ::|::.|...:|.:|:.:   .:..|.::::.:.|:    :..|||               ..||
Mouse  2026 KSINTEVLKFSLDSQVNHRMKKDLPSHIQEMLRRKEILDAQLDELSRQRALCRGGREMQRQELDE 2090

  Fly   574 ----------------KRYRNLKRAAENQLLEAADVICCTCVGAGDGRLSR-------VKFTSIL 615
                            |..:...:.|:|.::..:.|||||...:|...|..       |.|:.::
Mouse  2091 HIAIVSKERQELASKIKEVQGRPQRAQNTIILESHVICCTLSTSGGLLLESAFRGQGGVPFSCVI 2155

  Fly   616 IDESMQSTEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAARAGLSQSLFERLV---------- 670
            :||:.||.|.|.:.|::....:||||||..||.|.|:..||...|..||:..|..
Mouse  2156 VDEAGQSCEVETLSPLIHRCNKLILVGDPKQLPPTVISMKAQEYGYDQSMMARFCKLLEENVEQN 2220

  Fly   671 VLGIRP-FRLEVQYRMHPELSQFPSNFFYEGSLQNGVCAEDRRLKLDFPWPQPERPMFFLVTQGQ 734
            ::|..| .:|.:||||||::..||||:.|..:|:.....|..|...::|: ||.  :.|.|..|.
Mouse  2221 MIGRLPVLQLTIQYRMHPDICLFPSNYVYNKNLKTNRLTESIRCSSEWPF-QPY--LVFDVGDGS 2282

  Fly   735 EEIAGSGTSFLNRTEAANVEKITTRFLK---AGIKPEQIGIITPYEGQRAYLVQYMQ-------- 788
            |.  ....|::|..|...|.:| .:.:|   ..|....|||||.|:.|:..:.:.::
Mouse  2283 ER--RDNDSYINVQEIKLVMEI-IKLIKEKRKDISFRNIGIITHYKAQKTMIQKDLEKEFDKKGL 2344

  Fly   789 ----------YQGSLHSRLYQE---------------------------------IEIASVDAFQ 810
                      .|.|..|:..|:                                 .|:.:|||||
Mouse  2345 LQPIMMGESRQQDSEASKQQQKSSEFMHASDELGSSTVTQSGISSLENGATHTGPAEVDTVDAFQ 2409

  Fly   811 GREKDIIIMSCVRSNERQG-IGFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLNFYKD 874
            ||:||.||::|||::..|| ||||...:||||.:||||:.:.|:|:.:.|.:.|.|..|:...:.
Mouse  2410 GRQKDCIIVTCVRASAVQGSIGFLASLQRLNVTITRAKYSLFILGHLRTLMENQHWYELIQDAQK 2474

  Fly   875 RKVLVEGSLNNLKESLIHFQKPKKLV 900
            |..:::.|..|.:...:...|.|.::
Mouse  2475 RGAIIKTSDPNYRHDAMKILKLKPVL 2500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500	36/179 (20%)
		DNA2	122..897	CDD:224037	245/988 (25%)
		Mis12	210..299	CDD:283509	22/113 (19%)
		AAA_19	458..>515	CDD:289986	30/73 (41%)
		AAA_12	661..857	CDD:289832	76/261 (29%)
Setx	XP_006498142.1	SEN1_N	37..>334	CDD:372274
		DEXXQc_SETX	1910..2235	CDD:350800	86/326 (26%)
		AAA_12	2201..2455	CDD:372468	75/259 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810