DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Upf1 and SETX

DIOPT Version :9

Sequence 1:NP_001285145.1 Gene:Upf1 / 32153 FlyBaseID:FBgn0030354 Length:1180 Species:Drosophila melanogaster
Sequence 2:NP_001338457.1 Gene:SETX / 23064 HGNCID:445 Length:2706 Species:Homo sapiens


Alignment Length:1155 Identity:272/1155 - (23%)
Similarity:436/1155 - (37%) Gaps:362/1155 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 DMD-------DN----ELLPGADTQPTQYDYRDFTMPSTSQSQTQN---------DQLEIAQRCS 60
            |||       ||    ||:.|.||...:.|       |.|:.|.::         |.||..:  :
Human  1505 DMDLCSQMENDNYKLIELIHGKDTVEVEED-------SVSRPQLESLSGTKCKYKDCLETTK--N 1560

  Fly    61 AGDSHPRLASITNDLADLQFEEEDDEPGSSYVKELPPHACKYCGIHDPATVVMCNNCRKWFCNGR 125
            .|:..|:.:.:  ..||   |:...:||      |||.|.|..   .|.|.:..:.         
Human  1561 QGEYCPKHSEV--KAAD---EDVFRKPG------LPPPASKPL---RPTTKIFSSK--------- 1602

  Fly   126 GSTSGSHIINHLVRAKHREVTLHGEGPLGETILECYSCGVRNVFVLGFIPAKADSVVVLLCRQP- 189
             |||         |......:|.....|..: |:..|.|::::.       |....|.|:.::| 
Human  1603 -STS---------RIAGLSKSLETSSALSPS-LKNKSKGIQSIL-------KVPQPVPLIAQKPV 1649

  Fly   190 ------CAAQNSLKDMNWDQEQWK-PLIADRCFLAWLVKQPSEQG---QLRARQISAAQINKLEE 244
                  |...:.....|.:::..| |....:.|       ||...   .|.::.:|...:.::.:
Human  1650 GEMKNSCNVLHPQSPNNSNRQGCKVPFGESKYF-------PSSSPVNILLSSQSVSDTFVKEVLK 1707

  Fly   245 LWKENIEATF----------QDLEKPGIDSEPAHVLLRYEDGYQYEKTFGPLVRLEAEYDQKLKE 299
             ||..:...|          |.:.:|        |.:|:.:...|...|.||:.|.         
Human  1708 -WKYEMFLNFGQCGPPASLCQSISRP--------VPVRFHNYGDYFNVFFPLMVLN--------- 1754

  Fly   300 SATQENIEVRWDVGLNKKTIAYFTLAKTDSD-MK----LMHGDELRLHYVGELYNPWSEIGHVIK 359
              |.|.:...|....|::......:.|..:| :|    .::.:|..|  ..:||...:::  |..
Human  1755 --TFETVAQEWLNSPNRENFYQLQVRKFPADYIKYWEFAVYLEECEL--AKQLYPKENDL--VFL 1813

  Fly   360 VPDNFGDDVGLELKSSTNAPVKCTSNFTVDFIWKC--TSFDRMTRALC--------KFAIDRNSV 414
            .|:...:    |.|.:....::....:...::.|.  ||..|..:..|        .|..:.|.:
Human  1814 APERINE----EKKDTERNDIQDLHEYHSGYVHKFRRTSVMRNGKTECYLSIQTQENFPANLNEL 1874

  Fly   415 SNFIY-------------SRLLGH----GRADSNDEVLFRGPQPKLFSA------------PHLP 450
            .|.|.             ..|||.    .||..|       |.|..|..            .:|.
Human  1875 VNCIVISSLVTTQRKLKAMSLLGSRNQLARAVLN-------PNPMDFCTKDLLTTTSERIIAYLR 1932

  Fly   451 DLNRSQ------VYA-VKHALQ-RPLSLIQGPPGTGKTVTSATIVYQLV---------------K 492
            |.|..|      .|| |||:.. ..:.||.|||||||:.|...::|:|:               |
Human  1933 DFNEDQKKAIETAYAMVKHSPSVAKICLIHGPPGTGKSKTIVGLLYRLLTENQRKGHSDENSNAK 1997

  Fly   493 LHGGTVLVCAPSNTAVDQLTEKI------------------------------------------ 515
            :....||||||||.|||:|.:||                                          
Human  1998 IKQNRVLVCAPSNAAVDELMKKIILEFKEKCKDKKNPLGNCGDINLVRLGPEKSINSEVLKFSLD 2062

  Fly   516 ----HRTNLKV---VRVCAKSREAIDSPVSFLALH-------NQIRNMETNSELKKLQQLKDETG 566
                ||...::   |:...|.:|.:|..:..|:..       .:|:..|.:..:.|:.:   |..
Human  2063 SQVNHRMKKELPSHVQAMHKRKEFLDYQLDELSRQRALCRGGREIQRQELDENISKVSK---ERQ 2124

  Fly   567 ELSSADEKRYRNLKRAAENQLLEAADVICCTCVGAGDGRLSR-------VKFTSILIDESMQSTE 624
            ||:| ..|..:...:..::.::..:.:||||...:|...|..       |.|:.:::||:.||.|
Human  2125 ELAS-KIKEVQGRPQKTQSIIILESHIICCTLSTSGGLLLESAFRGQGGVPFSCVIVDEAGQSCE 2188

  Fly   625 PECMVPVVLGAKQLILVGDHCQLGPVVMCKKAARAGLSQSLFERL-----------VVLGIRPFR 678
            .|.:.|::....:||||||..||.|.|:..||...|..||:..|.           ::..:...:
Human  2189 IETLTPLIHRCNKLILVGDPKQLPPTVISMKAQEYGYDQSMMARFCRLLEENVEHNMISRLPILQ 2253

  Fly   679 LEVQYRMHPELSQFPSNFFYEGSLQNGVCAEDRRLKLDFPWPQPERPMFFLVTQGQEEIAGSGTS 743
            |.|||||||::..||||:.|..:|:.....|..|...|:|: ||.  :.|.|..|.|.  ....|
Human  2254 LTVQYRMHPDICLFPSNYVYNRNLKTNRQTEAIRCSSDWPF-QPY--LVFDVGDGSER--RDNDS 2313

  Fly   744 FLNRTEAANVEKITTRFLKAGIKPEQ-------IGIITPYEGQRAYLVQYMQYQGSLHSRLYQE- 800
            ::|..|.    |:....:|. ||.::       |||||.|:.|:..:      |..|.....:: 
Human  2314 YINVQEI----KLVMEIIKL-IKDKRKDVSFRNIGIITHYKAQKTMI------QKDLDKEFDRKG 2367

  Fly   801 -IEIASVDAFQGREKDIIIMSCVRSNERQG-IGFLNDPRRLNVALTRAKFGIIIVGN-------- 855
             .|:.:|||||||:||.:|::|||:|..|| ||||...:||||.:||||:.:.|:|:        
Human  2368 PAEVDTVDAFQGRQKDCVIVTCVRANSIQGSIGFLASLQRLNVTITRAKYSLFILGHLRTLMQLL 2432

  Fly   856 -----------------PK----VLAKQQLWNHLLNFYKDRKVLVEGSLNN-------------- 885
                             ||    .|.:.|.||.|:...:.|..:::....|              
Human  2433 PRSFCVHVNHSPFFSPEPKYLHWALKENQHWNQLIQDAQKRGAIIKTCDKNYRHDAVKILKLKPV 2497

  Fly   886 LKESLIH-------FQKPKKLVNSMNIGAHFMSTIIA--------DAKEV 920
            |:.||.|       ..:|:..:.|..:.:.|..|.:|        |:||:
Human  2498 LQRSLTHPPTIAPEGSRPQGGLPSSKLDSGFAKTSVAASLYHTPSDSKEI 2547

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Upf1NP_001285145.1 UPF1_Zn_bind 98..249 CDD:286500 28/161 (17%)
DNA2 122..897 CDD:224037 233/996 (23%)
Mis12 210..299 CDD:283509 17/101 (17%)
AAA_19 458..>515 CDD:289986 30/73 (41%)
AAA_12 661..857 CDD:289832 74/241 (31%)
SETXNP_001338457.1 SEN1_N 37..>351 CDD:315409
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1158..1219
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1237..1258
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1351..1385
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1579..1604 9/43 (21%)
AAA_11 1933..2218 CDD:315699 75/288 (26%)
Bipartite nuclear localization signal. /evidence=ECO:0000255 2070..2087 3/16 (19%)
AAA_12 2225..2424 CDD:315700 73/214 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2503..2525 3/21 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2585..2606
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2626..2706
Necessary for nuclear localization 2690..2706
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1112
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D62494at2759
OrthoFinder 1 1.000 - - FOG0000219
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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