Protein Alignment Upf1 and Ighmbp2

DIOPT Version :10

• Sequence 1: NP_572767.1
• Gene: Upf1 / 32153
• FlyBaseID: FBgn0030354
• Length: 1180
• Species: Drosophila melanogaster
• Sequence 2: NP_033238.2
• Gene: Ighmbp2 / 20589
• MGIID: 99954
• Length: 993
• Species: Mus musculus
• Alignment Length: 760
• Identity: 220/760 - (28%)
• Similarity: 319/760 - (41%)
• Gaps: 172/760 - (22%)

  Fly   289 LEAEYDQKLKESAT-QENIEVRWDVGLNKKTIAYFTLAKTDSDMKLMHGDELRLHYVGELYNPWS 352
            ||.|.|.:::|..: ||:..:|   .|..:.:....| :..|....::|..|      ..:.| .
Mouse    17 LELERDAEVEERRSWQEHSSLR---ELQSRGVCLLKL-QVSSQRTGLYGQRL------VTFEP-R 70

  Fly   353 EIGHVIKVPDN---FGDDVGLELKSSTNAPVKCTSNFTVDFIWKCT------SFDRM-------- 400
            :.|..:.:|.|   .||.|||   ..||.    .|......:.:.|      :||..
Mouse    71 KFGPAVVLPSNSFTSGDIVGL---YDTNE----NSQLATGVLTRITQKSVTVAFDESHDLQLNLD 128

  Fly   401 ---TRALCKFAIDRNSVSNFIYSRL---------LGHGRADSNDEVLFRG--PQPKLFSAP---H 448
               |..|.|.|   |.|:   |.||         ...|.|.|..::|...  |.|.:...|   :
Mouse   129 RENTYRLLKLA---NDVT---YKRLKKALMTLKKYHSGPASSLIDILLGSSTPSPAMEIPPLSFY 187

  Fly   449 LPDLNRSQVYAVKHAL-QRPLSLIQGPPGTGKTVTSATIVYQLVKLHGGTVLVCAPSNTAVDQLT 512
            ...|:.||..||..|| |:.|::|.||||||||.|...|:.|.|| .|..||.|||||.|||.|.
Mouse   188 NTTLDLSQKEAVSFALAQKELAIIHGPPGTGKTTTVVEIILQAVK-QGLKVLCCAPSNIAVDNLV 251

  Fly   513 EKIHRTNLKVVRVCAKSR--EAIDSPVSFLALHNQIRNMETNSELK----------KLQQLKDET 565
            |::.....:::|:...:|  |::... |..|:..:..|.:..::::          |..|.|.|.
Mouse   252 ERLALCKKRILRLGHPARLLESVQHH-SLDAVLARSDNAQIVADIRRDIDQVFGKNKKTQDKREK 315

  Fly   566 GELSSADE---KRYRNLKRAAENQLLEAADVICCTCVGA-GDGRLSRVK---FTSILIDESMQST 623
            |...|..:   |..:..:.||..|.|.||||:..|..|| .||.|..:.   |..:::||..|:.
Mouse   316 GNFRSEIKLLRKELKEREEAAIVQSLTAADVVLATNTGASSDGPLKLLPEDYFDVVVVDECAQAL 380

  Fly   624 EPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAARAGLSQSLFERLVVL-GIRPFR-LEVQYRMH 686
            |..|.:| :|.|.:.||.|||.||.|..:..:||.||||:||.|||... |....| |.||||||
Mouse   381 EASCWIP-LLKAPKCILAGDHRQLPPTTVSHRAALAGLSRSLMERLAEKHGAGVVRMLTVQYRMH 444

  Fly   687 PELSQFPSNFFYEGSLQNGVCAEDRRLKLDFP----WPQPERPMFFLVTQG-------QEEIAGS 740
            ..:..:.|...|.|.|.:........|| |.|    ..:...|:..:.|.|       :|:....
Mouse   445 QAIMCWASEAMYHGQLTSHPSVAGHLLK-DLPGVTDTEETRVPLLLIDTAGCGLLELEEEDSQSK 508

  Fly   741 GTSFLNRTEAANVEKITTRFLKAGIKPEQIGIITPYEGQRAYLVQYMQYQGSLHSRLYQEIEIAS 805
            |    |..|...|.......:.||::...|.:|.||..|...|.|.:       |..:.|:||.|
Mouse   509 G----NPGEVRLVTLHIQALVDAGVQAGDIAVIAPYNLQVDLLRQSL-------SNKHPELEIKS 562

  Fly   806 VDAFQGREKDIIIMSCVRSNERQGIGFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLN 870
            ||.||||||:.::::.||||.:..:|||.:.||:|||:|||:..:.::.:          :|.:|
Mouse   563 VDGFQGREKEAVLLTFVRSNRKGEVGFLAEDRRINVAVTRARRHVAVICD----------SHTVN 617

  Fly   871 FYKDRKVLVE-----GSLNNLKESLI--------------HFQKPKKLVNSMNI----------- 905
            .:...|.||:     |.:....|.|.              |.:.||....|.:|
Mouse   618 NHAFLKTLVDYFTEHGEVRTAFEYLDDIVPENYTHEGSQGHSRVPKPKCPSTSIRKPASDQESGQ 682

  Fly   906 ------------------GAHFMSTIIADAKEVMVPGSIYDRSGG 932
                              |:|..|...:.|.     ||  ||:||
Mouse   683 ETRAAPRHGRRKPSEKPPGSHVQSQHSSSAN-----GS--DRTGG 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_572767.1	UPF1_Zn_bind	98..249	CDD:401391
		1B_UPF1-like	302..390	CDD:394815	20/91 (22%)
		TIGR00376	355..880	CDD:273041	187/591 (32%)
		DEXXQc_UPF1	451..684	CDD:350797	96/254 (38%)
Ighmbp2	NP_033238.2	TIGR00376	19..640	CDD:273041	201/669 (30%)
		SS DNA-binding. /evidence=ECO:0000250	637..783		17/91 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	650..723		15/78 (19%)
		R3H_Smubp-2_like	724..782	CDD:100070
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	765..815
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	837..872
		Nuclear localization signal. /evidence=ECO:0000255	862..866
		ZnF_AN1	895..935	CDD:197545
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	953..993