back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Upf1 and Upf1

DIOPT Version :9

Sequence 1:	NP_001285145.1	Gene:	Upf1 / 32153	FlyBaseID:	FBgn0030354	Length:	1180	Species:	Drosophila melanogaster
Sequence 2:	NP_001116301.1	Gene:	Upf1 / 19704	MGIID:	107995	Length:	1124	Species:	Mus musculus

Alignment Length:	1217	Identity:	740/1217 - (60%)
Similarity:	867/1217 - (71%)	Gaps:	150/1217 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSVDTYAPSS-ALSFLDMDDNELLPGADTQPTQYDYRDFTMPSTSQSQTQN-------------- 50
            |||:.|.||| .|:|||.::.||| |||||.:::::.|||:||.:|:....
Mouse     1 MSVEAYGPSSQTLTFLDTEEAELL-GADTQGSEFEFTDFTLPSQTQTPPGGPGGAGGPGGAGAGG 64

  Fly    51 --DQLE-------IAQRCSAGDSHPRLASITNDLADLQFEEEDDEPGSSYVKELPPHACKYCGIH 106
              .||:       |.|..:..||   :|..:..||:|.|||  ||..:.|.|:||.|||.|||||
Mouse    65 AAGQLDAQVGPEGILQNGAVDDS---VAKTSQLLAELNFEE--DEEDTYYTKDLPVHACSYCGIH 124

  Fly   107 DPATVVMCNNCRKWFCNGRGSTSGSHIINHLVRAKHREVTLHGEGPLGETILECYSCGVRNVFVL 171
            |||.||.||..:||||||||:||||||:|||||||.:|||||.:||||||:||||:||.||||:|
Mouse   125 DPACVVYCNTSKKWFCNGRGNTSGSHIVNHLVRAKCKEVTLHKDGPLGETVLECYNCGCRNVFLL 189

  Fly   172 GFIPAKADSVVVLLCRQPCAAQNSLKDMNWDQEQWKPLIADRCFLAWLVKQPSEQGQLRARQISA 236
            ||||||||||||||||||||:|:||||:|||..||:|||.|||||:||||.||||.|||||||:|
Mouse   190 GFIPAKADSVVVLLCRQPCASQSSLKDINWDSSQWQPLIQDRCFLSWLVKIPSEQEQLRARQITA 254

  Fly   237 AQINKLEELWKENIEATFQDLEKPGIDSEPAHVLLRYEDGYQYEKTFGPLVRLEAEYDQKLKESA 301
            .||||||||||||..||.:||||||:|.||.||||||||.|||:..|||||:|||:||:|||||.
Mouse   255 QQINKLEELWKENPSATLEDLEKPGVDEEPQHVLLRYEDAYQYQNIFGPLVKLEADYDKKLKESQ 319

  Fly   302 TQENIEVRWDVGLNKKTIAYFTLAKTDS-----------DMKLMHGDELRLHYVGELYNPWSEIG 355
            ||:||.||||:|||||.||:|||.||||           ||:||.|||:.|.|.|:|...|..||
Mouse   320 TQDNITVRWDLGLNKKRIAFFTLPKTDSGNEDLVIIWLRDMRLMQGDEICLRYKGDLAPLWKGIG 384

  Fly   356 HVIKVPDNFGDDVGLELKSSTNAPVKCTSNFTVDFIWKCTSFDRMTRALCKFAIDRNSVSNFIYS 420
            ||||||||:||::.:||:||..|||:.|.||.|||:||.||||||..||..||:|..|||.:||.
Mouse   385 HVIKVPDNYGDEIAIELRSSVGAPVEVTHNFQVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYH 449

  Fly   421 RLLGHGRADSNDEVLFRGPQPKLFSAPHLPDLNRSQVYAVKHALQRPLSLIQGPPGTGKTVTSAT 485
            :||||    ..::|:.:...||.|:|..|||||.|||||||..||||||||||||||||||||||
Mouse   450 KLLGH----EVEDVVIKCQLPKRFTAQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSAT 510

  Fly   486 IVYQLVKLHGGTVLVCAPSNTAVDQLTEKIHRTNLKVVRVCAKSREAIDSPVSFLALHNQIRNME 550
            |||.|.:...|.||||||||.||||||||||:|.|||||:||||||||||||||||||||||||:
Mouse   511 IVYHLARQGNGPVLVCAPSNIAVDQLTEKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMD 575

  Fly   551 TNSELKKLQQLKDETGELSSADEKRYRNLKRAAENQLLEAADVICCTCVGAGDGRLSRVKFTSIL 615
            :..||:|||||||||||||||||||||.|||.||.:||..|||||||||||||.||::::|.|||
Mouse   576 SMPELQKLQQLKDETGELSSADEKRYRALKRTAERELLMNADVICCTCVGAGDPRLAKMQFRSIL 640

  Fly   616 IDESMQSTEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAARAGLSQSLFERLVVLGIRPFRLE 680
            ||||.|:|||||||||||||||||||||||||||||||||||:||||||||||||||||||.||:
Mouse   641 IDESTQATEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQ 705

  Fly   681 VQYRMHPELSQFPSNFFYEGSLQNGVCAEDRRLK-LDFPWPQPERPMFFLVTQGQEEIAGSGTSF 744
            |||||||.||.||||.||||||||||.|.||..| .||.||||::||||.|||||||||.||||:
Mouse   706 VQYRMHPALSAFPSNIFYEGSLQNGVTAADRVKKGFDFQWPQPDKPMFFYVTQGQEEIASSGTSY 770

  Fly   745 LNRTEAANVEKITTRFLKAGIKPEQIGIITPYEGQRAYLVQYMQYQGSLHSRLYQEIEIASVDAF 809
            ||||||||||||||:.||||.||:||||||||||||:|||||||:.||||::||||:||||||||
Mouse   771 LNRTEAANVEKITTKLLKAGAKPDQIGIITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAF 835

  Fly   810 QGREKDIIIMSCVRSNERQGIGFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLNFYKD 874
            ||||||.||:||||:||.|||||||||||||||||||::|:|||||||.|:||.||||||::||:
Mouse   836 QGREKDFIILSCVRANEHQGIGFLNDPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLSYYKE 900

  Fly   875 RKVLVEGSLNNLKESLIHFQKPKKLVNSMNIGAHFMSTIIADAKEVMVPGSIYDRSGGYGQGRQM 939
            :|.||||.||||:|||:.|.||:||||::|.||.||:|.:.||:|.::|||:||||   .|||.
Mouse   901 QKALVEGPLNNLRESLMQFSKPRKLVNTVNPGARFMTTAMYDAREAIIPGSVYDRS---SQGRP- 961

  Fly   940 VGQSMNGGQYGGSGGGPYGNSPLGYGTPSSNSMVGFGLGNGGNGAAGGNNNFGGAGPSWAAAHLH 1004
                                |.:.:.|....||:                   .||||..||.
Mouse   962 --------------------SNMYFQTHDQISMI-------------------SAGPSHVAAM-- 985

  Fly  1005 HDSIGYISNEHGAAALGNMPVPVGMFMNMSNIPPRFYNQHQQAIMAVKQNRAIQQQTGNFSPGNS 1069
                             |:|:|..:.|     ||                   ....|.|...|
Mouse   986 -----------------NIPIPFNLVM-----PP-------------------MPPPGYFGQAN- 1008

  Fly  1070 GPGVTGVGVGRSATPGGNKKTNKLGKSRVTGGGTGGAPLTQGSSVCNAAPYSQHPMPLS-LQMTQ 1133
            || ..|.|..::.|..|.::.|:.|   :.|......|.:|.|....:.|:||..:... :.|:|
Mouse  1009 GP-AAGRGTPKTKTGRGGRQKNRFG---LPGPSQTTLPNSQASQDVASQPFSQGALTQGYVSMSQ 1069

  Fly  1134 PSGFALSQ----QPELSQD--FGQ--ISQMDGLLSQDVAFNASGERS 1172
            ||  .:||    |||||||  .|.  .||:|..||||..:  .|||:
Mouse  1070 PS--QMSQPGLSQPELSQDSYLGDEFKSQIDVALSQDSTY--QGERA 1112

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.