Protein Alignment Upf1 and hzl-1

DIOPT Version :10

• Sequence 1: NP_572767.1
• Gene: Upf1 / 32153
• FlyBaseID: FBgn0030354
• Length: 1180
• Species: Drosophila melanogaster
• Sequence 2: NP_506213.2
• Gene: hzl-1 / 179760
• WormBaseID: WBGene00008099
• Length: 1099
• Species: Caenorhabditis elegans
• Alignment Length: 660
• Identity: 158/660 - (23%)
• Similarity: 260/660 - (39%)
• Gaps: 139/660 - (21%)

  Fly   385 NF-TVDFIWKCTSFDRMTRALCKFAIDRNSVSN--FIYSRLLGHGRADSNDEVLFRGPQPKLFSA 446
            || |..:|...:.|....|..|:|....:..||  .|.:.|.|....:|...:.:.    |.|..
 Worm   472 NFQTGTWIVSQSQFLETPRLDCEFLQKMSPSSNGRRIVTALYGGSPINSTGNINWN----KQFEF 532

  Fly   447 P-HLP-DLNRSQVYAVKHALQR-PLSLIQGPPGTGKTVTSATIVYQLVKLH------GGTVLVCA 502
            | .:| .||:.|...|...|.. ||.|...|.|.||::|..|...:|.|.:      ....|:..
 Worm   533 PSKIPIGLNQYQNQYVSMILSGVPLILGNSPFGCGKSMTIVTAAVELQKKYMRSESFNKQQLLVT 597

  Fly   503 PSNTAVDQLTE---KIHR-TNLKVVRVCAK---------SREAIDSPVSFLALHNQIRNMETNSE 554
            .||.|...|.|   |:|: .:::.:|..::         |:..:|.|:   .:.::.....||:|
 Worm   598 QSNNAGVNLIEFALKLHKCDHIRFLRYVSESNWNSLPDSSKTELDMPI---LMEDEFFEWATNTE 659

  Fly   555 LKK------LQQLKDETGELSS----------ADEKR-YRN-LKRAAENQ-----------LLEA 590
            ::|      .:::|....|.|:          .:.|| |.| ||...|::           .|.|
 Worm   660 IQKENGENLTREMKKAIVEQSTQKYHCKGILVGEAKRIYENILKNQREHKPSQAILKEAFFALYA 724

  Fly   591 ADVICCTCVGAGDGRLSRVKFTSILIDESMQSTEPECMVPVVLGAKQLI------------LVGD 643
            .|:|..|.     ..:..:...::|.|.|....:....||    ...||            ||||
 Worm   725 PDIIVSTA-----DSIHNLLENNVLRDVSNIQFDEASQVP----EHTLISLLHKFPNASFGLVGD 780

  Fly   644 HCQLGPVVMC--------------KKAARAGLSQSLFERLVVLGIRPFRLEVQYRMHPELSQFPS 694
            ..||  ...|              |..|||. ...:|.:.:        |.:.||.||..::..|
 Worm   781 INQL--PAYCDDDLQGLLKDYGIGKTMARAS-RDKMFPQSI--------LRLVYRCHPTTTKILS 834

  Fly   695 NFFYEGSLQNGVCAEDR----RLKLDFPWPQPERPMFFLVTQGQEEIAGSGTSFLNRTEAANVEK 755
            :.||.|.|.:||....|    |::.|. ||....|:  ||...:::....|||..|.:|...|.:
 Worm   835 DLFYNGQLISGVEKNQRDEFMRMRPDI-WPNSSFPI--LVLNHEKDGYRMGTSVANNSEKDQVVR 896

  Fly   756 ITTRFLKA----GIKPEQIGIITPYEGQRAYLVQYMQYQGSLHSRLYQEIEIASVDAFQGREKDI 816
            |.:...|.    |:....||||:.|:.|.:.|...::         ..:::..::|||||.|:::
 Worm   897 IVSLLTKKVKGYGLSESDIGIISFYKAQTSLLADALK---------KTDVKCGTIDAFQGTEREV 952

  Fly   817 IIMSCVRSNERQGIGFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLNFYKDRKVLVE- 880
            :|:.|...|...   |:.:..|:|||::||:...||:||...|.|.:.|:.:....:..|..:|
 Worm   953 MIVCCTNKNPSL---FMQEGTRVNVAMSRARQATIIIGNIAKLKKAKHWDTIAQSAQINKCSMEV 1014

  Fly   881 ---GSLNNLKESLIHF----QKPKKLVNSMNIGAHFMSTIIADAKEVMVPGSIYDRSGGYGQGRQ 938
               |.....:..::..    :|..|:..:.|.|.|...:.....||.....| ..:.....:.|.
 Worm  1015 STFGGSEQKQPQMVQIKCTAKKSNKIQKNQNEGKHISISQTVKTKEDTEQSS-KPQQRRRRRNRN 1078

  Fly   939 MVGQSMNGGQ 948
            .:||:...|:
 Worm  1079 NIGQNSTNGR 1088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_572767.1	UPF1_Zn_bind	98..249	CDD:401391
		1B_UPF1-like	302..390	CDD:394815	3/5 (60%)
		TIGR00376	355..880	CDD:273041	144/582 (25%)
		DEXXQc_UPF1	451..684	CDD:350797	67/307 (22%)
hzl-1	NP_506213.2	AAA_11	544..786	CDD:404072	58/255 (23%)
		DNA2	<693..993	CDD:440729	87/334 (26%)