DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Upf1 and DNA2

DIOPT Version :9

Sequence 1:NP_001285145.1 Gene:Upf1 / 32153 FlyBaseID:FBgn0030354 Length:1180 Species:Drosophila melanogaster
Sequence 2:XP_006717743.1 Gene:DNA2 / 1763 HGNCID:2939 Length:1090 Species:Homo sapiens


Alignment Length:719 Identity:193/719 - (26%)
Similarity:305/719 - (42%) Gaps:186/719 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   285 PLVRLEAEYDQKLKESATQENIEVRWDVGLNKKTIAYF-------TLAKTDSDMKLMHGDELRLH 342
            |:|.|     .|::|. ||.         |.:..:.||       ||.....|.|..| ..:.|.
Human   449 PIVML-----PKIEEE-TQH---------LKQTHLEYFSLWCLMLTLESQSKDNKKNH-QNIWLM 497

  Fly   343 YVGELYNPWSEIGHVIKVPDNFGDDVGLELKSSTNAPVKCTSNFTVDF--------IWKCTSFDR 399
            ...|:....|.||::|::               .:..:.|...:..:|        :....:.||
Human   498 PASEMEKSGSCIGNLIRM---------------EHVKIVCDGQYLHNFQCKHGAIPVTNLMAGDR 547

  Fly   400 ----------------------MTRALCKFAIDRNSVSNFIYSRLLGHGRADSN----------- 431
                                  ||...|  .:||| :|....|.|....:.:.|           
Human   548 VIVSGEERSLFALSRGYVKEINMTTVTC--LLDRN-LSVLPESTLFRLDQEEKNCDIDTPLGNLS 609

  Fly   432 -------------DEVL-FRGPQ--PKLFSA-PH---------LPDLNRSQVYAVKHA-LQRPLS 469
                         |.:: ||.||  ..|.|. ||         |..||:.|..|:|.. |.:..:
Human   610 KLMENTFVSKKLRDLIIDFREPQFISYLSSVLPHDAKDTVACILKGLNKPQRQAMKKVLLSKDYT 674

  Fly   470 LIQGPPGTGKTVTSATIVYQLVKLHGGTVLVCAPSNTAVDQLTEKIHRTNLKVVRVCAKSREAID 534
            ||.|.||||||.|..|:| :::...|.:||:.:.:::|||.:..|:           ||.:    
Human   675 LIVGMPGTGKTTTICTLV-RILYACGFSVLLTSYTHSAVDNILLKL-----------AKFK---- 723

  Fly   535 SPVSFLALHNQIRNMETNSELKKLQQLKDETGELSSADEKRYRNLKRAAENQLLEAADVICCTCV 599
              :.||.|          .:::|:.....:..|......|..::|  |...:|..:..::..||:
Human   724 --IGFLRL----------GQIQKVHPAIQQFTEQEICRSKSIKSL--ALLEELYNSQLIVATTCM 774

  Fly   600 GAGDGRLSRVKFTSILIDESMQSTEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAARAGLSQS 664
            |......||..|...::||:.|.::|.|:.|:.. :::.:|||||.||.|:|:.::|...|:|:|
Human   775 GINHPIFSRKIFDFCIVDEASQISQPICLGPLFF-SRRFVLVGDHQQLPPLVLNREARALGMSES 838

  Fly   665 LFERLVVLGIRPFRLEVQYRMHPELSQFPSNFFYEGSLQNGVCAEDR--------------RLKL 715
            ||:||........:|.|||||:.::....:...|||.|:   |..|:              :|:|
Human   839 LFKRLEQNKSAVVQLTVQYRMNSKIMSLSNKLTYEGKLE---CGSDKVANAVINLRHFKDVKLEL 900

  Fly   716 DF-------PWP----QPERPMFFLVTQ---GQEEIAGSGTSFLNRTEAANVEKITTRFLKAGIK 766
            :|       ||.    :|..|:.||.|.   ..|::...|.|  |.|||..:..:|:.|:|||..
Human   901 EFYADYSDNPWLMGVFEPNNPVCFLNTDKVPAPEQVEKGGVS--NVTEAKLIVFLTSIFVKAGCS 963

  Fly   767 PEQIGIITPYEGQRAYLVQYMQYQGSLHSRLYQEIEIASVDAFQGREKDIIIMSCVRSNERQGIG 831
            |..||||.||.       |.::....|.:|....:|:.:||.:|||:|.|:::|.||||:...:|
Human   964 PSDIGIIAPYR-------QQLKIINDLLARSIGMVEVNTVDKYQGRDKSIVLVSFVRSNKDGTVG 1021

  Fly   832 -FLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLNFYKDRKVLVEGSLNNLKESLIH--- 892
             .|.|.||||||:||||..:|::|....|........|||.....|:::: ..:...|||.|   
Human  1022 ELLKDWRRLNVAITRAKHKLILLGCVPSLNCYPPLEKLLNHLNSEKLIID-LPSREHESLCHILG 1085

  Fly   893 -FQK 895
             ||:
Human  1086 DFQR 1089

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Upf1NP_001285145.1 UPF1_Zn_bind 98..249 CDD:286500
DNA2 122..897 CDD:224037 193/719 (27%)
Mis12 210..299 CDD:283509 4/13 (31%)
AAA_19 458..>515 CDD:289986 21/57 (37%)
AAA_12 661..857 CDD:289832 78/224 (35%)
DNA2XP_006717743.1 Dna2 101..312 CDD:285859
Cas4_I-A_I-B_I-C_I-D_II-B <291..427 CDD:294426
TIGR00376 501..1062 CDD:273041 169/621 (27%)
P-loop_NTPase 655..905 CDD:304359 80/283 (28%)
AAA_12 835..1047 CDD:289832 78/223 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG1112
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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