Protein Alignment Upf1 and C05C10.2

DIOPT Version :10

• Sequence 1: NP_572767.1
• Gene: Upf1 / 32153
• FlyBaseID: FBgn0030354
• Length: 1180
• Species: Drosophila melanogaster
• Sequence 2: NP_001364625.1
• Gene: C05C10.2 / 174546
• WormBaseID: WBGene00007329
• Length: 1525
• Species: Caenorhabditis elegans
• Alignment Length: 1013
• Identity: 223/1013 - (22%)
• Similarity: 375/1013 - (37%)
• Gaps: 281/1013 - (27%)

  Fly   122 CNGRGSTSGSHIINHLVRAKH------REVTLHGEGPLGETILECYSCGVRNVFVLGFIPAKADS 180
            |||.||.:.....:..:.:::      .::||....|....:               |...|...
 Worm   617 CNGHGSDAFKIPFDVSMSSQNTCTWMASKITLPSRPPPASVL---------------FSFMKNRM 666

  Fly   181 VVVLLCRQPC-----AAQNSLKDMNWDQEQWKPLIADRCFLAWLVKQPSEQ-GQLRARQISAAQI 239
            .||..|.:|.     :.||...|:.:....:||...:..|....:|:...| |.:..|..|
 Worm   667 AVVKGCDEPMNVEVKSIQNVEPDLIYKGTAFKPEKPELNFTEGFIKKKRHQIGSITLRIAS---- 727

  Fly   240 NKLEELWKENIEATFQDLEKPGIDSEPAHVLLRYEDGYQYEKTFGPLVRLEAEYDQKLKESATQE 304
                   ..|...|..:.::..||:|      .|:.|            :.|..::|..|.:..|
 Worm   728 -------YPNSFGTIYNFQESDIDNE------HYKIG------------INAFSEEKFTEISLDE 767

  Fly   305 NIEVRWDVGLNKKTIAYFTLAKT----DSDMKLMHGDELRLHYVGELY---NPWSE-------IG 355
            ..::     :...::..|:.|.|    ..|.:....:|::.:.:..::   ||.|:       .|
 Worm   768 REKI-----VETCSLMGFSAANTIFNGRFDCRAFKMEEIKKNGMTVMFCIENPTSQPTLGLWCAG 827

  Fly   356 HVIKVPDNFGD------------DVG---LELKSSTNAPVK------------------------ 381
            :.|.:....||            |:|   :..:.|.:.|.|
 Worm   828 NRIVIGGPNGDVNGAIETVIDDPDIGYLRIAARLSRDIPKKFSFKGDGEFFVSQREVFENEILDD 892

  Fly   382 ---------CTSNFTVDFIWKCTSFDRMTRALCKFAID-RNSVSNFIYSRLLGHGRADSNDEVLF 436
                     |.....::.::.....:|:       .:| |:|....:.|:|.|.|...|..:...
 Worm   893 GYFKTLDPGCNGRRIIETLYGGKPLERV-------VVDKRDSSIERMMSQLFGVGSGISEHKTSG 950

  Fly   437 RGPQ--PKLFSAPHLPD---LNRSQVYAVKHALQ-RPLSLIQGPPGTGKTVTSATIVYQLVKL-H 494
            :..:  |..|..|..|:   ||:.|...|:..|. .||.:...|.|.||::|..|...:|.|| .
 Worm   951 KKSEDTPTQFYFPSTPEPLALNKYQCEYVQMLLDGNPLIIGSSPFGCGKSMTIITAALELYKLKK 1015

  Fly   495 GGTVLVCAPSNTAVDQLTEKIHRT---------NLKVVRVCAKS---------REAIDSP----- 536
            ....|:...||.|...|.:...|.         :||.||..::.         |...|.|
 Worm  1016 NRKQLLITQSNYASVNLIDIAQRVCLSGDDDLKDLKFVRFVSEKNWNELPSNCRTDSDMPYLMNK 1080

  Fly   537 --------------VSFLALHNQ-------IRNMETNSEL--KKLQQLKDETGELSSADEKRYRN 578
                          ::.|..|:.       |:|...|..|  ..:.|:.|:.    |||
 Worm  1081 LFKDWAMGRIDLTNLTCLKTHHYVQMVSHIIKNDLVNPMLFGDHIAQIYDKL----SAD------ 1135

  Fly   579 LKRAAENQLLEAA-------DVICCTCVGAGDGRLSRVK-FTSILIDESMQSTEPECMVPVVLGA 635
            ..||...|.|..|       |::..|...| .|.|:.:: ..::.|||:.|..  ||   .:||.
 Worm  1136 FSRAPHAQTLVEAFFMIYKPDLVMVTADSA-KGLLNILRDVCAVQIDEASQLA--EC---TLLGL 1194

  Fly   636 KQLI------LVGDHCQLGPVVMCKKAARAGLSQ----SLFERLVVLGIRPF-RLEVQYRMHPEL 689
            .:..      |:||..||.|  .|::.....|..    :..||.:...:.|. .|...||.||:.
 Worm  1195 LKSFNNASFGLIGDIHQLPP--YCEEGLEGKLKDFGIGNTMERAIKEKMFPVCTLRNVYRCHPKT 1257

  Fly   690 SQFPSNFFYEGSLQNGV---CAEDRRLKLDFPWPQPERPMFFLVTQGQEEIAGSGTSFLNRTEAA 751
            ::..|..||:|:|.:||   ...|...|.|..||.|:.||.|:...|.....|:.||  |.:|.:
 Worm  1258 TELLSELFYDGALVSGVSELARSDFMTKRDDFWPNPKFPMMFVNNTGASTKMGTSTS--NSSEKS 1320

  Fly   752 NVEKITTRFL---KAGIKPEQIGIITPYEGQRAYLVQYMQYQGSLHSRLYQEIEIASVDAFQGRE 813
            .|.:|....:   :..:.|..||:|:.|..|.:.|.::::..|         ::..:||||||.|
 Worm  1321 IVGEIVQNLINDPRNPVNPSDIGVISFYSAQTSILTEHLRGSG---------VKCGTVDAFQGSE 1376

  Fly   814 KDIIIMSCVRSNERQGIGFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLNFYKDRKVL 878
            |:|||| | .:|||.. .|:....|||||::|||...||:|:...|.:...|:.::|     |:.
 Worm  1377 KEIIIM-C-STNERIS-DFMQLSNRLNVAMSRAKQVTIIIGHLDGLRRANYWSTIVN-----KIE 1433

  Fly   879 VEGSLNNLKESLIHFQKPKKLVNSMNIGAHFMSTIIADAKEVMVPGSIYDRSGGYGQGRQMVGQS 943
            ..|:|.|..:   .:|..::  |.:::.::.:.:....:|:        .|:..|....:.|.:.
 Worm  1434 QNGNLVNAND---WYQNQRR--NKVSLSSYPLISTSRQSKQ--------QRANEYNSQHKHVKRQ 1485

  Fly   944 MNGGQYGGSGGGPYGNSPLGYGTPSS--NSM----VGF 975
            .|.                .||:..|  ||:    |||
 Worm  1486 SNN----------------DYGSQRSVTNSLNPEFVGF 1507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_572767.1	UPF1_Zn_bind	98..249	CDD:401391	25/138 (18%)
		1B_UPF1-like	302..390	CDD:394815	19/149 (13%)
		TIGR00376	355..880	CDD:273041	161/651 (25%)
		DEXXQc_UPF1	451..684	CDD:350797	70/302 (23%)
C05C10.2	NP_001364625.1	DEAD-like_helicase_N	970..>1040	CDD:475120	22/69 (32%)
		DEAD-like_helicase_N	<1180..1252	CDD:475120	20/78 (26%)
		SF1_C_Upf1	1253..1433	CDD:350195	66/198 (33%)