Protein Alignment Upf1 and Mov10

DIOPT Version :9

• Sequence 1: NP_001285145.1
• Gene: Upf1 / 32153
• FlyBaseID: FBgn0030354
• Length: 1180
• Species: Drosophila melanogaster
• Sequence 2: NP_001156912.1
• Gene: Mov10 / 17454
• MGIID: 97054
• Length: 1077
• Species: Mus musculus
• Alignment Length: 900
• Identity: 225/900 - (25%)
• Similarity: 349/900 - (38%)
• Gaps: 262/900 - (29%)

  Fly    87 PGSSYVKELPPHACKYCGI----HDPATVVMCNNCRKWFCNGRGSTSGSHIINHLVRAKHREVTL 147
            ||.||...:      ||..    :.||||:       |...|.|. ||:.
Mouse   265 PGESYELHI------YCKTSIVGYFPATVL-------WELLGPGE-SGAE--------------- 300

  Fly   148 HGEGPLGETILECYSCGVRNVFVLGFIPAKADSVVVL-------LCRQPCAAQNSLKDMNWDQEQ 205
                            |....::..|:.|.|.|.:..       ..|.|...:||:.....::.:
Mouse   301 ----------------GAETFYIARFLAAVAHSPLAAQLKPTTPFKRPPRLTRNSVLTNRIEEGE 349

  Fly   206 ------------------WKPLIADRCFLAWLVKQPS------EQGQLRARQISAAQINKLEELW 246
                              :.|.|..|..|..|::.||      |..:::|         :||...
Mouse   350 RPDRAKGYELELSLALGTYYPPILLRQLLPTLLQGPSIFTAPKEVAEIKA---------QLETTL 405

  Fly   247 K-ENIEATFQDLEKPGIDSEPAHVLLRYEDGYQYEKTFGPLVRLEAEYDQKLKESATQENIEVRW 310
            | .|.|...:             :||..|:             |:.|:|.:..:   .:::.:.|
Mouse   406 KSRNYEVKLR-------------LLLHLEE-------------LQMEHDIRHYD---LDSVPMTW 441

  Fly   311 D-VGLNKKTIAYFTLAKTDSDMKLMHGDELRLHYVGELY--NPWSEIGHVIKVPDNFGDDVGLEL 372
            | |..|.:.:........:|...::.||.|......|..  :|.:..|.|.||.   .|.|.|..
Mouse   442 DPVDQNPRLLTLEVPGVAESRPSVLRGDHLFALLSSETQQDDPVTYKGFVHKVE---LDRVKLSF 503

  Fly   373 KSSTNAPVKCTSNFTVDFIWKCTSFDRMTRAL----------CKFAIDRNSVSNF-------IYS 420
            .:|..:.......|.|:|.:.........|||          ..|.:....||..       :|.
Mouse   504 STSLLSRFVDGLTFKVNFTFNRQPLRVQHRALELTGRWVLWPMLFPVASRGVSLLPSDVKFKLYD 568

  Fly   421 RLLGHGRADSNDEVLFRGPQPKLFSAPHLPDLNRSQVYAVKHALQ---RPLS-LIQGPPGTGKTV 481
            |.|     :||.|                      |:.|:||.::   ||.. :|.|||||||||
Mouse   569 RSL-----ESNPE----------------------QLQAMKHIVRGTTRPAPYIIFGPPGTGKTV 606

  Fly   482 TSATIVYQLVK-LHGGTVLVCAPSNTAVDQLTEKIHRTNL--KVVRVCAKSREAIDSPVSFLALH 543
            |....:.|:|| |....:|.|||||:..|.|.::: |.:|  .:.|:.|.||:
Mouse   607 TLVEAIKQVVKHLPKAHILACAPSNSGADLLCQRL-RVHLPSSIYRLLAPSRD------------ 658

  Fly   544 NQIRNMETNSELKKLQQLKDETGELSSADEKRYRNLKRAAENQLLEAADVICCTCVGAGDGRLSR 608
                          ::.:.::.....:.|.|:...:..|.::  |:...|:..|.:.|  .||..
Mouse   659 --------------IRMVPEDIKTCCNWDAKKGEYVYPAKKH--LQQYRVLITTLITA--SRLVS 705

  Fly   609 VK-----FTSILIDESMQSTEPECMVPV--VLGAK-------QLILVGDHCQLGPVVMCKKAARA 659
            .:     ||.|.|||:....|||.:|.:  ::..|       ||:|.||..|||||:....|.:.
Mouse   706 AQFPIDHFTHIFIDEAGHCMEPESLVAIAGLMDVKETGNPGGQLVLAGDPRQLGPVLRSPLALKH 770

  Fly   660 GLSQSLFERLVVL---------GIRP---FRLEVQYRMHPELSQFPSNFFYEGSLQNGVCAEDRR 712
            ||..||.|||:..         |..|   .:|...||.||.:...|:..:|:|.||  .||:...
Mouse   771 GLGYSLLERLLAYNSLYKKGPNGYDPQFITKLLRNYRSHPTILDIPNQLYYDGELQ--ACADVVD 833

  Fly   713 LKLDFPW---PQPERPMFFLVTQGQEEIAGSGTSFLNRTEAANVEKITTRFL-------KAGIKP 767
            .:....|   ||...|:.|....|::|..|:..||.|..|||.|.....:.|       ||.:.|
Mouse   834 RERFCRWEGLPQQGFPIIFHGVMGKDEREGNSPSFFNPEEAATVTSYLKQLLAPSSKKGKARLSP 898

  Fly   768 EQIGIITPYEGQRAYLVQYMQY-QGSLHSRL-----YQEIEIASVDAFQGREKDIIIMSCVRSNE 826
            ..:|:|:||..|    |:.::| ...|...|     .:::::.||:.|||:|:.:|::|.|||::
Mouse   899 RNVGVISPYRKQ----VEKIRYCITKLDRELRGLDDIKDLKVGSVEEFQGQERSVILISTVRSSQ 959

  Fly   827 R-------QGIGFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLNFYKD 874
            .       ..:|||.:|:|.|||:||||..:|:||||.:|.....|...|.|.|:
Mouse   960 SFVQLDLDFNLGFLKNPKRFNVAVTRAKALLIVVGNPLLLGHDPDWKTFLEFCKE 1014

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500	32/186 (17%)
		DNA2	122..897	CDD:224037	214/860 (25%)
		Mis12	210..299	CDD:283509	19/95 (20%)
		AAA_19	458..>515	CDD:289986	28/61 (46%)
		AAA_12	661..857	CDD:289832	75/230 (33%)
Mov10	NP_001156912.1	AAA_11	574..765	CDD:289831	67/243 (28%)
		P-loop_NTPase	574..>761	CDD:304359	65/239 (27%)
		AAA_12	772..996	CDD:289832	74/229 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810