Protein Alignment Upf1 and smg-2

DIOPT Version :10

• Sequence 1: NP_572767.1
• Gene: Upf1 / 32153
• FlyBaseID: FBgn0030354
• Length: 1180
• Species: Drosophila melanogaster
• Sequence 2: NP_490829.1
• Gene: smg-2 / 171696
• WormBaseID: WBGene00004880
• Length: 1069
• Species: Caenorhabditis elegans
• Alignment Length: 1215
• Identity: 529/1215 - (43%)
• Similarity: 706/1215 - (58%)
• Gaps: 204/1215 - (16%)

  Fly     2 SVDTYAPS--SALSFLDMDDNELLPGADTQPTQYDYRDFTMPSTSQSQTQNDQLEIAQRCSAGDS 64
            |.|.|:.|  ..|:|:|.:|:.:..| :||.:|:.|..|::|      ||:.|        |.|.
 Worm     4 SDDEYSRSHGETLTFVDPEDDGVSIG-NTQDSQFAYEQFSVP------TQSSQ--------ATDL 53

  Fly    65 HP-RLASITNDLA--DLQFEEEDDEPG---SSYVKELPPHACKYCGIHDPATVVMCNNCRKWFCN 123
            .| .....||||.  |::.:|.|.|..   ....::||.|||:||||.||..|..|..|||||||
 Worm    54 LPGGTDGTTNDLPFHDVEDDESDSEKSLTEEQQQQKLPEHACRYCGISDPLCVAKCTVCRKWFCN 118

  Fly   124 GRGSTSGSHIINHLVRAKHREVTLHGEGPLGETILECYSCGVRNVFVLGFIPAKADSVVVLLCRQ 188
            ....|||.||::|:||::|:|...|.:.|.|:|.||||.||.:|||.|||||.|.|.|||::||.
 Worm   119 SNDGTSGGHIVHHMVRSQHKEAYTHKDSPCGDTQLECYRCGSKNVFNLGFIPGKKDQVVVIICRT 183

  Fly   189 PCAAQNSLKDMNWDQEQWKPLIADRCFLAWLVKQPSEQGQLRARQISAAQINKLEELWKENIEAT 253
            |||:.....|.||..|.||.:||::..|:|:|..|||:...|||:|:|.|..::||||:::.|||
 Worm   184 PCASIAFQNDDNWSPEDWKSVIAEKQLLSWIVNVPSEEQVARARKITATQAVRMEELWRDHPEAT 248

  Fly   254 FQDLEKPGIDSEPAHVLLRYEDGYQYEKTFGPLVRLEAEYDQKLKESATQENIEVRWDVGLNKKT 318
            ..||.|||:|.||.||.|||.|.:.|.|.|.|||.:|||||:::||||:|....|||:.||.:..
 Worm   249 VDDLNKPGLDREPDHVQLRYVDAHHYSKVFRPLVAIEAEYDRRVKESASQAVGTVRWEQGLRQSV 313

  Fly   319 IAYFTLAK-TDSDMKLMHGDELRLHYVGEL-YNPWSEIGHVIKVPDNFGDDVGLELKSSTNAPV- 380
            :|:|.|.: .|..|||..||||||.:...: .:.|::||.|.|:|||.||:||:|::.:.:..|
 Worm   314 LAFFHLPQFADGVMKLAKGDELRLKHSQTVDGSEWTKIGSVFKIPDNHGDEVGIEIRGAVDKSVM 378

  Fly   381 KCTSNFTVDFIWKCTSFDRMTRALCKFAIDRNSVSNFIYSRLLGHGRADSNDEVLFRGPQPKLFS 445
            :....||||.:|..|:|:|..:||.....|..::|.::|.:||||    ..:|::.:...|:..|
 Worm   379 ESRIMFTVDVVWNATTFERQYKALAALLNDSKAISPYLYQKLLGH----PAEEMMLKFDLPRRLS 439

  Fly   446 APHLPDLNRSQVYAVKHALQRPLSLIQGPPGTGKTVTSATIVYQLVKLHGGTVLVCAPSNTAVDQ 510
            ...||:||.||:.|||..|.||||||||||||||||.||||||.||:...|.||||:|||.|||.
 Worm   440 VAGLPELNSSQMQAVKQVLTRPLSLIQGPPGTGKTVVSATIVYHLVQKTEGNVLVCSPSNIAVDH 504

  Fly   511 LTEKIHRTNLKVVRVCAKSREAIDSPVSFLALHNQIRNMETNSELKKLQQLKDETGELSSADEKR 575
            |.||||:|.|||||:||:|||..::.|.:|.|.:|::.| ..:||:||.|||||.|||...|:.|
 Worm   505 LAEKIHKTGLKVVRLCARSREHSETTVPYLTLQHQLKVM-GGAELQKLIQLKDEAGELEFKDDLR 568

  Fly   576 YRNLKRAAENQLLEAADVICCTCVGAGDGRLSRVKFTSILIDESMQSTEPECMVPVVLGAKQLIL 640
            |..|||..|::||.|||||||||..|.|.|||:::..::|||||.|:||||.:|.::.|.:||:|
 Worm   569 YMQLKRVKEHELLAAADVICCTCSSAADARLSKIRTRTVLIDESTQATEPEILVSIMRGVRQLVL 633

  Fly   641 VGDHCQLGPVVMCKKAARAGLSQSLFERLVVLGIRPFRLEVQYRMHPELSQFPSNFFYEGSLQNG 705
            |||||||||||:|||||.||||||||||||:||||||||:|||||||.||:||||.||:||||||
 Worm   634 VGDHCQLGPVVICKKAAIAGLSQSLFERLVLLGIRPFRLQVQYRMHPVLSEFPSNVFYDGSLQNG 698

  Fly   706 VCAEDRRLK-LDFPWPQPERPMFFLVTQGQEEIAGSGTSFLNRTEAANVEKITTRFLKAGIKPEQ 769
            |...||.:. :|:.||:|.:|.||....|.||::.||||||||||||||||:.::.:|||::|.|
 Worm   699 VTENDRHMTGVDWHWPKPNKPAFFWHCSGSEELSASGTSFLNRTEAANVEKLVSKLIKAGVQPHQ 763

  Fly   770 IGIITPYEGQRAYLVQYMQYQGSLHSRLYQEIEIASVDAFQGREKDIIIMSCVRSNERQGIGFLN 834
            ||:||||||||:::|.||..||:|:|:||:.:||||||||||||||.||::|||||:..|||||:
 Worm   764 IGVITPYEGQRSFIVNYMHTQGTLNSKLYENVEIASVDAFQGREKDYIIVTCVRSNDILGIGFLS 828

  Fly   835 DPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLNFYKDRKVLVEGSLNNLKESLIHFQKPKKL 899
            ||||||||:||||:|:::|||.||||:..||:.|:|.||.:::|.||.:|.||
 Worm   829 DPRRLNVAITRAKYGLVLVGNAKVLARHDLWHELINHYKSKEMLYEGPINALK------------ 881

  Fly   900 VNSMNIGAHFMSTIIADAKEVMVPGSIYDRSGGYGQGRQMVGQSMNGGQYGGSGGGPYGNSPLGY 964
                                                                         ||..
 Worm   882 -------------------------------------------------------------PLNL 885

  Fly   965 GTPSSNSMVGFGLGNGGNGAAGGNNNFGGAGPSWAAAHLHHDSIGYISNEHGAAAL--------- 1020
            ..|.:....       .|..||..|.||       ...:.:....|.||:.....|
 Worm   886 ALPKATIRT-------KNNIAGNANRFG-------IKRMQYTFNEYKSNDPSQPRLPPTYSNSQN 936

  Fly  1021 ------------GNMPVPVGMFMNMSNIPPRFY----NQ-------------HQQAIMAVKQNRA 1056
                        .|:|:|..|      :.|..|    ||             ..:|.|.:.|. .
 Worm   937 LLSMSKLAQTFNKNVPIPAHM------MDPNVYAAARNQKDRRRGDQRRPPPQAEAAMDLSQG-M 994

  Fly  1057 IQQQTGNFSPGNSGPGVTGVGVGRSATPGGNKKTNKL--GKSRVTGGGTGGAPLTQGSSVCNAAP 1119
            :.||:..:.|                 .|.:.::..|  |.|.::|       .:|..:......
 Worm   995 MSQQSQQYPP-----------------QGASSQSQYLLDGASSLSG-------WSQSQTTTTTTR 1035

  Fly  1120 YSQHPMPLSLQMTQPSGFALSQQPELSQDFGQISQ-MDGLL-SQD 1162
            :..|....:           ||| ::|||...|.| ||.|| |||
 Worm  1036 HHHHRQNRN-----------SQQ-QMSQDMDDIQQKMDDLLFSQD 1068

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_572767.1	UPF1_Zn_bind	98..249	CDD:401391	80/150 (53%)
		1B_UPF1-like	302..390	CDD:394815	36/90 (40%)
		TIGR00376	355..880	CDD:273041	311/526 (59%)
		DEXXQc_UPF1	451..684	CDD:350797	152/232 (66%)
smg-2	NP_490829.1	UPF1_Zn_bind	93..243	CDD:401391	80/149 (54%)
		1B_UPF1-like	297..387	CDD:394815	35/89 (39%)
		DEXXQc_UPF1	445..677	CDD:350797	152/232 (66%)
		AAA_12	654..851	CDD:463780	134/196 (68%)