Protein Alignment Upf1 and Y106G6D.5

DIOPT Version :10

• Sequence 1: NP_572767.1
• Gene: Upf1 / 32153
• FlyBaseID: FBgn0030354
• Length: 1180
• Species: Drosophila melanogaster
• Sequence 2: NP_001300390.1
• Gene: Y106G6D.5 / 13181740
• WormBaseID: WBGene00014965
• Length: 676
• Species: Caenorhabditis elegans
• Alignment Length: 781
• Identity: 203/781 - (25%)
• Similarity: 320/781 - (40%)
• Gaps: 196/781 - (25%)

  Fly   185 LCRQPCAAQNSLKDMNWDQEQWKPLIADRCFLAWLVKQPSEQGQLRARQISAAQINKLEELWKEN 249
            ||:...:|| |||..:                ..|.|||..:..|..:.:.  .:.:..::::..
 Worm    12 LCKLSTSAQ-SLKKSS----------------RLLKKQPKNKISLTPKFLD--NVREWPKIFEAE 57

  Fly   250 IEATFQDLEKPGIDSEPAHVLLRYEDGYQYEK----TFGPLVRLEAEYDQKLKESATQEN---IE 307
            |||.|:.|::          ::|.:.|::..:    ..|.|:.....||....|..|...   :.
 Worm    58 IEAQFEKLDE----------MIRNKVGWRVIEERGLCVGNLIVTSKYYDSYCGEVITLSGDAILR 112

  Fly   308 VRWDVGLNKKTIAYFTLAKTDSDMKLMHGDELRLHYVGELYNPWSEIGHVIKVPDNFGDDVGLEL 372
            .||                      |..|..:       |.|..:|.||:.||.|..
 Worm   113 TRW----------------------LKAGTPV-------LLNKLNEDGHLQKVSDGH-------- 140

  Fly   373 KSSTNAPVKCTSNFTVDFIWKCTSFDRMTRALCKFAIDRN---SVSNFIYSRLLGHGRAD----- 429
                  .|.||:.     |.|..::|           |:|   |..|:|.:.....|...
 Worm   141 ------VVDCTAG-----IVKVCAYD-----------DKNVDFSTLNYILTPSTNSGALKFLQSV 183

  Fly   430 -------SNDEV-----LFRG-PQPKLFSAP--HLPD-LNRSQVYAVKHAL--QRPLSLIQGPPG 476
                   |:|.|     .:|. |.|.:....  :||: ||.|||.||..|:  ||.|..||||||
 Worm   184 IKNPSSLSSDSVHLVNLAYRSIPMPSIHDRKIGNLPETLNPSQVAAVSAAMNTQRNLLCIQGPPG 248

  Fly   477 TGKTVTSATIVYQLVKLHGGTVLVCAPSNTAV----DQLTEKIHRTNLKVVRVCAKSREAIDSPV 537
            ||||...|.||:||:| ....||||||::.||    |..|.::         :.....|..:..:
 Worm   249 TGKTRVIAEIVHQLMK-KKKKVLVCAPTHVAVRNAMDATTGRM---------IEEMPEEKAEQQL 303

  Fly   538 SFLALHNQIRNMETNSELKKLQQLKDETGELSSAD------EKRYRNLKRAAENQLLEAADVICC 596
            ..||  |.....:.:....||:::|.:...:|::|      ...|..::.:....:......:..
 Worm   304 CLLA--NTKDEFQNHKSASKLEEIKKQLSTMSTSDPLYKKMSYEYYLIRNSIFRSIFYPKLAVFS 366

  Fly   597 TCVGAGDGRLSRVKFTS--ILIDESMQSTEPECMVPVVL--GAKQLILVGDHCQLGPVVMCKKAA 657
            |...:...:|....:.:  :::||:.|.|||...|||:.  ..|:||||||..||..||:..||.
 Worm   367 TLGTSSIQKLPEYHWNADVMIVDEAAQCTEPATWVPVLTTPSCKKLILVGDQKQLPAVVLSDKAM 431

  Fly   658 RAGLSQSLFERLV---------VLGIRPFRLEVQYRMHPELSQFPSNFFYEGSLQNGVCAEDRRL 713
            :.....||.|:|.         :|      |..||||:.::..:.:..|||..|.......|..|
 Worm   432 KGNFKLSLMEKLAEEFSSNNINIL------LNEQYRMNKKIMNWSNEVFYENQLTAHSTVSDITL 490

  Fly   714 KLDFPWPQPE-----RPMFFL-----VTQGQEEIAGSGTSFLNRTEAANVEKITTRF-LKAGIKP 767
            : |.....||     .|:..:     ..:..||.  ...||.|..|...|.:...|. :..||.|
 Worm   491 R-DICPNLPEDHVLNNPIMMINMENVKDRSHEEF--ESHSFTNTDELNLVTEYVNRLVVDLGINP 552

  Fly   768 EQIGIITPYEGQRAYLVQYMQYQGSLHSRLYQEIEIASVDAFQGREKDIIIMSCVRSNERQGIGF 832
            :.|.:|:||..|...|.:.:.::          :::.:||||||.|:.::|...||.|:...|||
 Worm   553 KAIAVISPYYAQIEKLRRSIPFR----------VDVNTVDAFQGHERQVVIFCLVRDNDEGQIGF 607

  Fly   833 LNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLNFYK---DRKVLVEGSL----NNLKESL 890
            ||:.||||||:|||:...:::||.:::...:   |||..||   ..||:...|:    |:|:|:.
 Worm   608 LNETRRLNVAVTRARRQFVLIGNGRMMKGNK---HLLKLYKHLQSEKVIFGPSILETFNDLEEAA 669

  Fly   891 I 891
            :
 Worm   670 L 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_572767.1	UPF1_Zn_bind	98..249	CDD:401391	12/63 (19%)
		1B_UPF1-like	302..390	CDD:394815	16/90 (18%)
		TIGR00376	355..880	CDD:273041	167/587 (28%)
		DEXXQc_UPF1	451..684	CDD:350797	78/258 (30%)
Y106G6D.5	NP_001300390.1	TIGR00376	55..653	CDD:273041	186/700 (27%)