DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Upf1 and ighmbp2

DIOPT Version :9

Sequence 1:	NP_001285145.1	Gene:	Upf1 / 32153	FlyBaseID:	FBgn0030354	Length:	1180	Species:	Drosophila melanogaster
Sequence 2:	XP_004913487.1	Gene:	ighmbp2 / 100497063	XenbaseID:	XB-GENE-6258282	Length:	984	Species:	Xenopus tropicalis

Alignment Length:	808	Identity:	216/808 - (26%)
Similarity:	327/808 - (40%)	Gaps:	227/808 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 RQISAAQINKLEELWKENIEATFQDLEKPGIDSEPAHVLLRYEDGYQYEKTFGPLVRLEAEYDQK 296
            |:...|:|.: ...|:|||  :.::|::.|:                      .|::|:.
Frog    13 REEREAEIQE-TRTWRENI--SLKELQRRGV----------------------CLLKLQV----- 47

  Fly   297 LKESATQENIEVRWDVGLNKKTIAYFTLAKTDSDMKLMHGDELRLHYVGELYNPWSEIGHVIKVP 361
                |.|.       .||..:.:..||..|.||:..|                |.:..|.
Frog    48 ----ANQR-------TGLYGRLLVTFTPRKYDSEAIL----------------PSNSFGP----- 80

  Fly   362 DNFGDDVGLELKSSTNAPVKC-----------------TSNFTVDFIWKCT----------SFDR 399
               ||.|||...||.|..:..                 :||.:::...:||          ::.|
Frog    81 ---GDIVGLYEASSPNEQLATGIVAGVTQKVVNVAFDESSNDSLNLGTECTYRLLKLANDVTYKR 142

  Fly   400 MTRALCKFAIDRNSVSNFIYSRLLGHGRADSNDEVLFRGPQP---------KLFSAPHLPDLNRS 455
            :.|||......|:             |:|.|..:|||...:|         :.|:.    .|:.|
Frog   143 IKRALTALGQYRS-------------GQASSLIDVLFCSSEPSHSVQKRQVEFFNL----SLDDS 190

  Fly   456 QVYAVKHAL-QRPLSLIQGPPGTGKTVTSATIVYQLVKLHGGTVLVCAPSNTAVDQLTEKIHRTN 519
            |..||..:| ||.:::|.||||||||.|...|:.|.|| .|..||.|||||.|||.|.|::....
Frog   191 QKEAVSFSLNQREVAVIHGPPGTGKTTTVVEIILQAVK-EGLKVLCCAPSNVAVDNLVERLSVFK 254

  Fly   520 LKVVR------------------VCAKS---------REAIDSPVSFLALHNQIRNMETNSELKK 557
            .|::|                  |.|:|         |..||               :|.:::||
Frog   255 EKILRLGHPARLLESLQHHSLDAVLARSDNAQIVADIRRDID---------------QTFAKMKK 304

  Fly   558 LQQLKDETGELS--SADEKRYRNLKRAAENQLLEAADVICCTCVGAG-DGRLSRVK---FTSILI 616
            |...::::|..:  .|..|..:..:.||..:.|:.|:||..|..||. ||.|..:.   |..::|
Frog   305 LHGKQEKSGYRTEIKALRKELKEREEAAMVETLKRANVILATNTGASLDGPLKLLPEDYFDLVVI 369

  Fly   617 DESMQSTEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAARAGLSQSLFERLV-VLGIRPFR-L 679
            ||..|:.|..|.:. :|.||:.||.|||.||.|.::..|||..|||.||.||:. ..|.:..: |
Frog   370 DECAQALEASCWIS-LLQAKKCILAGDHKQLPPTIISHKAAANGLSLSLMERVTEKYGEKVVKML 433

  Fly   680 EVQYRMHPELSQFPSNFFYEGSLQNGVCAEDRRLKLDFP----WPQPERPMFFLVT-------QG 733
            .||||||..:.|:.|...|.|.|..........|| |.|    ..:...|:..:.|       ..
Frog   434 TVQYRMHQSIMQWASEALYGGRLTAHSSVSQHLLK-DLPGVSVTEETSIPLLLIDTAHCGLFEME 497

  Fly   734 QEEIAGSGTSFLNRTEAANVEKITTRFLKAGIKPEQIGIITPYEGQRAYLVQYMQYQGSLHSRLY 798
            .|:....|    |..|...|:.......|||:||:.|.:|.||..|...|.|.::.:       |
Frog   498 VEDEQSKG----NPGEVQLVDLHIQALTKAGVKPQDIAVIAPYNLQVDMLRQCLRQR-------Y 551

  Fly   799 QEIEIASVDAFQGREKDIIIMSCVRSNERQGIGFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQ 863
            .::||.|||.||||||:.:::|.||||.:..:|||.:.||:|||:|||:..:.::.:...:...|
Frog   552 PDLEIKSVDGFQGREKEAVVLSFVRSNSKGEVGFLAEDRRINVAVTRARRHVAVICDSHTVGNHQ 616

  Fly   864 LWNHLLNFYKDRKVLVEGSLNNLKESLIHFQKPKKLVNSMNIGAHFMSTIIADAKEVMVPGSIYD 928
            ....|:.::.:     .|.:....|.|                            |.:||.....
Frog   617 FLKDLITYFSE-----HGEVRTAFEYL----------------------------EDIVPEKYSR 648

  Fly   929 RSGGYGQGRQMVGQSMNGGQYGGSGGGP 956
            .:|..|:......:::...|...:.|||
Frog   649 ENGTTGKPETQAKKAVGTKQKKPNTGGP 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500	4/16 (25%)
		DNA2	122..897	CDD:224037	207/747 (28%)
		Mis12	210..299	CDD:283509	11/66 (17%)
		AAA_19	458..>515	CDD:289986	32/57 (56%)
		AAA_12	661..857	CDD:289832	70/208 (34%)
ighmbp2	XP_004913487.1	TIGR00376	20..636	CDD:273041	203/731 (28%)
		R3H_Smubp-2_like	714..773	CDD:100070
		zf-AN1	890..927	CDD:376545
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910