Protein Alignment Upf1 and setx

DIOPT Version :10

• Sequence 1: NP_572767.1
• Gene: Upf1 / 32153
• FlyBaseID: FBgn0030354
• Length: 1180
• Species: Drosophila melanogaster
• Sequence 2: XP_002936221.1
• Gene: setx / 100145435
• XenbaseID: XB-GENE-966858
• Length: 2535
• Species: Xenopus tropicalis
• Alignment Length: 1148
• Identity: 281/1148 - (24%)
• Similarity: 444/1148 - (38%)
• Gaps: 357/1148 - (31%)

  Fly     5 TYAPSSALSFLDMDDNELLPGADTQPTQYDYRDFTMPSTSQSQTQNDQLEIAQRCSAGDSH--PR 67
            |.:.:.|:|....|:.:|       ....::.:.:..|:::|..||.::.:..:.....||  .:
 Frog  1309 TTSHAEAISNKPRDERKL-------SISNEHLEISRTSSNKSTAQNGEISLNSKLEKSSSHVLEK 1366

  Fly    68 LASITNDLA------------------DLQFEEED----------------DEPGSSYVK----- 93
            |.:..:|.|                  ||...:.|                ||.|:|.|.
 Frog  1367 LVTSADDNAFVLPPTNEKESNNYEDDYDLFLTQADPVDMEMCSQVEYDIDLDEGGASRVSDFSGS 1431

  Fly    94 --ELPPHA------CKYCGIHDPATVVMCNNCRKWFCNGRGSTSGSHIINHLVRAKHREVTLHGE 150
              |||..|      ....|::|...     .|:...|......:|.|...|:...| .:..|..:
 Frog  1432 DAELPKLATGSGTELPKMGLNDGVP-----KCKYTNCTEMVKVAGDHCPKHMPPEK-ADDHLFAK 1490

  Fly   151 GPLGETILECYSCGVRNVFV--------------------LGFIPAKADSVVVLLCR--QPCAAQ 193
            ..|..::.:   .....||.                    .|.:.||..|....:.:  :|...|
 Frog  1491 PGLPPSVSK---PSTTKVFASSNTSRTASLTKDLENFPRPQGILKAKPQSAKAPVPKLPKPLTVQ 1552

  Fly   194 NSLKDMNWDQEQWKPLIADRCFLAWLVKQP-----SEQGQLRARQISAAQ--INKLEELW--KEN 249
            |...|.|   ...:|||..    :.:..:|     ||.|:||.   .|||  :.:.::.|  :|.
 Frog  1553 NRASDTN---SVLQPLINQ----SNVPSKPSYSAVSEAGKLRP---YAAQKPLQQRDQGWLMREL 1607

  Fly   250 IEATFQDLEKPGIDSEPAH--------VLLRYEDGYQYEKTFGPLVRLEAEYDQKLKESATQENI 306
            ::..|:..:.......|::        |.:::....:|...|.||:.|.           |.|::
 Frog  1608 LQWKFEMFDNVSRFGPPSNLCQLPLLKVPIKFSSYEEYFNVFFPLMLLN-----------TFESL 1661

  Fly   307 EVRWDVGLNKKTIAYFTLAK---------------------TDSDMKL----------------- 333
            ...|.|   |:...:..|.|                     .|:|:.:
 Frog  1662 AQEWSV---KQKAIHTDLCKLHLQNFCPDGLVNRGEFQVWFRDADLCMQRHPKEDDLVFLCMPES 1723

  Fly   334 ---MHGDEL-----RLHYVGELYNPWSEIGHVIKVPDNFGDDVGL---------ELKSSTNAPVK 381
               :.|:|:     |:::.|.:    |......:......:...|         .|.:..|..|:
 Frog  1724 TPSLSGEEMVSHGARVYHTGYV----SRFNRSHRTQSQEKEQYTLCDLCIHTQGNLSAFRNQQVR 1784

  Fly   382 CTSNFTVDFIWKCTSFDRMTRALCKFAIDRNSVSNFIYSRLLGHGRADSNDEVLFRG---PQPKL 443
            |.      .|....:..|..|||.:  :.||.                     |||.   |.|..
 Frog  1785 CA------VIGSLITTQRQFRALLQ--LQRNP---------------------LFRPIILPNPAD 1820

  Fly   444 F-----------SAPHLPDLNRSQVYAVKHAL----QRP----LSLIQGPPGTGKTVTSATIVYQ 489
            |           |.|.|.:.|..|.||::.|.    |.|    :.||.|||||||:.|...::|:
 Frog  1821 FIPRDNAASESSSFPSLKEYNSDQRYAIEKAYSMVKQHPRLPRICLIHGPPGTGKSKTIVGLLYR 1885

  Fly   490 LVKLHGGT---------------VLVCAPSNTAVDQLTEKI--------HRTN--------LKVV 523
            ::..:|.:               ||||||||.|:|.|.:||        |..|        :.:|
 Frog  1886 ILMENGSSTVPVQNLSAKNKRNRVLVCAPSNAALDDLMKKIILEFKEKCHNKNTPLGNCGDINLV 1950

  Fly   524 RVCAKSREAIDSPVSFLAL----HNQIRNMETNSELKKLQQLKD-ETGELS--SADEKRYRN--- 578
            |:.|:  :.|.|.|...:|    :::|...:.:.||.|.::|.| ...|||  .|.||..:|
 Frog  1951 RLGAE--KTISSDVVKFSLDCQVNHRITRAQQDQELHKRKELLDRRLDELSRRRALEKCNKNTCA 2013

  Fly   579 ------LKRAAENQLLEAAD---------------------VICCTCVGAGD-------GRLSRV 609
                  .:.:.|.|||  ||                     |||||...:|.       .:|.:.
 Frog  2014 PLDEEIARLSKERQLL--ADSLKLVRRRPQELQRTIILESHVICCTLSTSGGILLESAFRQLGQE 2076

  Fly   610 KFTSILIDESMQSTEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAARAGLSQSLFERLVVL-- 672
            .|:.:::||:.||.|.|.::|::....:|:||||..||.|.|:..||...|..|||..|:...
 Frog  2077 PFSCVIVDEAGQSCEVENLIPLLHRCSKLVLVGDPEQLPPTVISMKAEELGYGQSLMSRMCSFLD 2141

  Fly   673 --GIRP--FRLEVQYRMHPELSQFPSNFFYEGSLQNGVCAEDRRLKLDFPWPQPERPMFFLVTQG 733
              |.:.  ..|.|||||||::..|||::||:..|:.....|:.|...|:|: ||.  |.|.|..|
 Frog  2142 STGTKSPVLHLTVQYRMHPDICLFPSHYFYKRMLKTDRATEEVRCSSDWPF-QPY--MVFDVADG 2203

  Fly   734 QEEIAGSGTSFLNRTEAANVEKITTRFLKAGIKPEQ-------IGIITPYEGQRAYLVQYMQYQG 791
            .|:  ....||.|..|.    |:....:|. ||..:       ||:||||..|:..:::
 Frog  2204 FEQ--KERESFCNPQEI----KVAVALIKL-IKSRKKEFCFRNIGVITPYRAQKMRIIE------ 2255

  Fly   792 SLHSRLYQEI---EIASVDAFQGREKDIIIMSCVRSNERQ-GIGFLNDPRRLNVALTRAKFGIII 852
            .|......:|   |:.:||.||||:||.||::|||:|..| |||||...:||||.:|||||.:.|
 Frog  2256 ELRRAFGNDIRPGEVDTVDGFQGRQKDCIIVTCVRANSTQGGIGFLASRQRLNVTITRAKFSLFI 2320

  Fly   853 VGNPKVLAKQQLWNHLLNFYKDRKVLVEGSLNNLKESLIHFQK 895
            :|:.:.|.:.:.||||:...:.|     |:|...:|.  |:|:
 Frog  2321 LGSLRTLMENKDWNHLIQDAQRR-----GALIKTREE--HYQR 2356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_572767.1	UPF1_Zn_bind	98..249	CDD:401391	35/187 (19%)
		1B_UPF1-like	302..390	CDD:394815	19/142 (13%)
		TIGR00376	355..880	CDD:273041	193/647 (30%)
		DEXXQc_UPF1	451..684	CDD:350797	95/321 (30%)
setx	XP_002936221.1	SEN1_N	38..>347	CDD:432746
		DEXXQc_SETX	1840..2157	CDD:438712	95/320 (30%)
		DNA2	<1946..2343	CDD:440729	137/416 (33%)
		PHA03247	<2365..2534	CDD:223021