Protein Alignment Upf1 and upf1

DIOPT Version :9

• Sequence 1: NP_001285145.1
• Gene: Upf1 / 32153
• FlyBaseID: FBgn0030354
• Length: 1180
• Species: Drosophila melanogaster
• Sequence 2: XP_002938872.2
• Gene: upf1 / 100135270
• XenbaseID: XB-GENE-6258022
• Length: 1100
• Species: Xenopus tropicalis
• Alignment Length: 1193
• Identity: 743/1193 - (62%)
• Similarity: 870/1193 - (72%)
• Gaps: 126/1193 - (10%)

  Fly     1 MSVDTYAPSS-ALSFLDMDDNELLPGADTQPTQYDYRDFTMPSTSQSQTQN-DQLE--------I 55
            |||:.|.||| .|:|||.::.||| |||||.:::::.|||:||.:|:|.|: :||:        :
 Frog     1 MSVEAYGPSSQTLTFLDTEEAELL-GADTQGSEFEFTDFTLPSQTQTQGQSQNQLDGQVNGPDGM 64

  Fly    56 AQRCSAGDSHPRLASITNDLADLQFEEEDDEPGSSYVKELPPHACKYCGIHDPATVVMCNNCRKW 120
            .|..:..|...:.:.:   |.:|.|||  ||..:.|.|:||.|||.||||||||.||.||..:||
 Frog    65 LQNGTVDDGVGKTSQL---LGELNFEE--DEEDTYYTKDLPVHACSYCGIHDPACVVYCNTSKKW 124

  Fly   121 FCNGRGSTSGSHIINHLVRAKHREVTLHGEGPLGETILECYSCGVRNVFVLGFIPAKADSVVVLL 185
            ||||||:||||||:|||||||.:|||||.:||||||:||||:||.||||:|||||||||||||||
 Frog   125 FCNGRGNTSGSHIVNHLVRAKCKEVTLHKDGPLGETVLECYNCGCRNVFLLGFIPAKADSVVVLL 189

  Fly   186 CRQPCAAQNSLKDMNWDQEQWKPLIADRCFLAWLVKQPSEQGQLRARQISAAQINKLEELWKENI 250
            ||||||:|:||||:|||..||:|||.|||||:||||.||||.|||||||:|.||||||||||||.
 Frog   190 CRQPCASQSSLKDINWDSSQWQPLIQDRCFLSWLVKIPSEQEQLRARQITAQQINKLEELWKENP 254

  Fly   251 EATFQDLEKPGIDSEPAHVLLRYEDGYQYEKTFGPLVRLEAEYDQKLKESATQENIEVRWDVGLN 315
            .||.:||||||:|.||.||||||||.|||:..|||||:|||:||:|||||.||:||.||||:|||
 Frog   255 SATLEDLEKPGVDEEPQHVLLRYEDAYQYQNIFGPLVKLEADYDKKLKESQTQDNITVRWDLGLN 319

  Fly   316 KKTIAYFTLAKTDSDMKLMHGDELRLHYVGELYNPWSEIGHVIKVPDNFGDDVGLELKSSTNAPV 380
            ||.||||||.||||||:||.|||:.|.|.|:|...|..||||||||||:||::.:||:||..|||
 Frog   320 KKRIAYFTLPKTDSDMRLMQGDEICLRYKGDLAPLWKGIGHVIKVPDNYGDEIAIELRSSVGAPV 384

  Fly   381 KCTSNFTVDFIWKCTSFDRMTRALCKFAIDRNSVSNFIYSRLLGHGRADSNDEVLFRGPQPKLFS 445
            :.|.||.|||:||.||||||..||..||:|..|||.:||.:||||    ..::|:.:...||.|:
 Frog   385 EVTHNFQVDFVWKSTSFDRMQSALKTFAVDETSVSGYIYHKLLGH----EVEDVIIKCQLPKRFT 445

  Fly   446 APHLPDLNRSQVYAVKHALQRPLSLIQGPPGTGKTVTSATIVYQLVKLHGGTVLVCAPSNTAVDQ 510
            |..|||||.|||||||..|||||||||||||||||||||||||.|.:...|.||||||||.||||
 Frog   446 AQGLPDLNHSQVYAVKTVLQRPLSLIQGPPGTGKTVTSATIVYHLARQGNGPVLVCAPSNIAVDQ 510

  Fly   511 LTEKIHRTNLKVVRVCAKSREAIDSPVSFLALHNQIRNMETNSELKKLQQLKDETGELSSADEKR 575
            ||||||:|.|||||:|||||||||||||||||||||||||:..||:|||||||||||||||||||
 Frog   511 LTEKIHQTGLKVVRLCAKSREAIDSPVSFLALHNQIRNMESMPELQKLQQLKDETGELSSADEKR 575

  Fly   576 YRNLKRAAENQLLEAADVICCTCVGAGDGRLSRVKFTSILIDESMQSTEPECMVPVVLGAKQLIL 640
            ||.|||.||.:||..|||||||||||||.||::::|.|||||||.|:||||||||||||||||||
 Frog   576 YRALKRTAERELLMNADVICCTCVGAGDPRLAKMQFRSILIDESTQATEPECMVPVVLGAKQLIL 640

  Fly   641 VGDHCQLGPVVMCKKAARAGLSQSLFERLVVLGIRPFRLEVQYRMHPELSQFPSNFFYEGSLQNG 705
            |||||||||||||||||:||||||||||||||||||.||:|||||||.||.||||.|||||||||
 Frog   641 VGDHCQLGPVVMCKKAAKAGLSQSLFERLVVLGIRPIRLQVQYRMHPALSAFPSNIFYEGSLQNG 705

  Fly   706 VCAEDRRLK-LDFPWPQPERPMFFLVTQGQEEIAGSGTSFLNRTEAANVEKITTRFLKAGIKPEQ 769
            |.|.||..| .||.||||::||||.|||||||||.||||:||||||||||||||:.||||.||:|
 Frog   706 VTAADRVKKGFDFQWPQPDKPMFFYVTQGQEEIASSGTSYLNRTEAANVEKITTKLLKAGAKPDQ 770

  Fly   770 IGIITPYEGQRAYLVQYMQYQGSLHSRLYQEIEIASVDAFQGREKDIIIMSCVRSNERQGIGFLN 834
            |||||||||||:|||||||:.||||::||||:||||||||||||||.||:||||:||.|||||||
 Frog   771 IGIITPYEGQRSYLVQYMQFSGSLHTKLYQEVEIASVDAFQGREKDFIILSCVRANEHQGIGFLN 835

  Fly   835 DPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLNFYKDRKVLVEGSLNNLKESLIHFQKPKKL 899
            ||||||||||||::|:|||||||.|:||.|||||||:||::||||||.||||:|||:.|.||:||
 Frog   836 DPRRLNVALTRARYGVIIVGNPKALSKQPLWNHLLNYYKEQKVLVEGPLNNLRESLMQFSKPRKL 900

  Fly   900 VNSMNIGAHFMSTIIADAKEVMVPGSIYDRSGGYGQGRQMVGQSMNGGQYGGSGGGPYGNSPLGY 964
            ||::|.||.||:|.:.||:|.::|||:||||   .|||.                     |.:.:
 Frog   901 VNTINPGARFMTTAMYDAREAIIPGSVYDRS---SQGRP---------------------SNMYF 941

  Fly   965 GTPSSNSMVGFGLGNGGNGAAGGNNNFGGAGPSWAAAHLHHDSIGYISNEHGAAALGNMPVPVGM 1029
            .|                                      ||.||.|.:........|:|:|..:
 Frog   942 QT--------------------------------------HDQIGMIGSGPSHVTAMNIPIPFNL 968

  Fly  1030 FMNMSNIPPRFYNQHQQAIMAVKQNRAIQQQTGNFSPGNS-GPGVTGVGVGRSATPGGNKKTNKL 1093
            .|     ||                   ....|.|...|. .|| .|:..|: ||.||.:|...:
 Frog   969 VM-----PP-------------------MPPPGYFGQANGPAPG-RGMPKGK-ATRGGRQKQRGI 1007

  Fly  1094 GKSRVTGGGTGGAPLTQGSSVCNAAPYSQHPMPLS-LQMTQPSGFALSQ----QPELSQD--FGQ 1151
            |   :.|...|..|.:|.|....:.|:||.|:... :.|:|||  .:||    |||||||  .|.
 Frog  1008 G---LPGMSQGNMPNSQASQDVVSQPFSQGPLTQGYISMSQPS--QMSQPGLSQPELSQDSYLGD 1067

  Fly  1152 --ISQMDGLLSQDVAFNASGERS 1172
              .||:|..||||..:  .|||:
 Frog  1068 EFKSQIDVALSQDSTY--QGERA 1088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Upf1	NP_001285145.1	UPF1_Zn_bind	98..249	CDD:286500	122/150 (81%)
		DNA2	122..897	CDD:224037	600/775 (77%)
		Mis12	210..299	CDD:283509	68/88 (77%)
		AAA_19	458..>515	CDD:289986	46/56 (82%)
		AAA_12	661..857	CDD:289832	162/196 (83%)
upf1	XP_002938872.2	DNA2	126..890	CDD:224037	595/767 (78%)
		DEXXQc_UPF1	451..684	CDD:350797	197/232 (85%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	332	1.000	Domainoid score	I1153
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2185
Inparanoid	1	1.050	1371	1.000	Inparanoid score	I134
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D62494at2759
OrthoFinder	1	1.000	-	-		FOG0000219
OrthoInspector	1	1.000	-	-		oto104959
Panther	1	1.100	-	-	LDO	PTHR10887
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3712
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160