DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wisp and PAP2

DIOPT Version :9

Sequence 1:	NP_001285144.1	Gene:	wisp / 32152	FlyBaseID:	FBgn0260780	Length:	1373	Species:	Drosophila melanogaster
Sequence 2:	NP_014526.1	Gene:	PAP2 / 854034	SGDID:	S000005475	Length:	584	Species:	Saccharomyces cerevisiae

Alignment Length:	505	Identity:	100/505 - (19%)
Similarity:	176/505 - (34%)	Gaps:	140/505 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   834 LGSESQWSGTSNRSRLGHNGHPSISPTPSALGSAQLSPHL---AEMRVQHPLHQQH----PPSHA 891
            :|::|..:.:|.:.:..|||....|.....:...|.|..|   .|:.:....::|.    |..|.
Yeast     1 MGAKSVTASSSKKIKNRHNGKVKKSKKIKKVRKPQKSISLNDENEVEILPSRNEQETNKLPKDHV 65

  Fly   892 S--------HRPHGQMGGHAMSSYVPHRPPPPPHPSISSPNPTPVATGAGGPWYEMILPPDRYLA 948
            :        |:.....|   ...|..|...|...||.:..:.||.....|..  :.:...|.:::
Yeast    66 TADGILVLEHKSDDDEG---FDVYDGHFDNPTDIPSTTEESKTPSLAVHGDE--KDLANNDDFIS 125

  Fly   949 ----------------QARNIEVTVQPEKLICMCKY---------------DNLSAEIWKRFRG- 981
                            :.:.:|:..:.:|.|....|               |.|:.|| |.|..
Yeast   126 LSASSEDEQAEQEEEREKQELEIKKEKQKEILNTDYPWILNHDHSKQKEISDWLTFEI-KDFVAY 189

  Fly   982 ----------AQQTHNKFKLKMRLWRYLYLW----MHQPMFERYRICLVGSTITGFGTDSSDIDM 1032
                      ..||.:..:..::     .||    :|          :.||..|......||||
Yeast   190 ISPSREEIEIRNQTISTIREAVK-----QLWPDADLH----------VFGSYSTDLYLPGSDID- 238

  Fly  1033 CLLPEQ--GVHPHQHQYHQHHHFHNEKRTEALIILTLFNAVLKDTEVFQDFNLIEARVPILRFKD 1095
            |::..:  |.....:.|....|...:.             :..:.||     :.:|||||::|.:
Yeast   239 CVVTSELGGKESRNNLYSLASHLKKKN-------------LATEVEV-----VAKARVPIIKFVE 285

  Fly  1096 ISNGIEVDLNFNNCVGIKNTYLLQLYAQMDWRTRPLVVIVKLWAQYHDINDAKRMTISSYSLVLM 1160
            ..:||.:|::|....||:...|::.:.......|.||:|||.:.....:|:.....:..:|::.:
Yeast   286 PHSGIHIDVSFERTNGIEAAKLIREWLDDTPGLRELVLIVKQFLHARRLNNVHTGGLGGFSIICL 350

  Fly  1161 VLHYLQHACVPHVLPCLHSLYPEKFQLGQQDCLDLDLIEPIEPYQALNTQTLGEHLLGFFKYY-S 1224
            |..:|      |:.|.:                   :...|:|     ...||..|:.||:.| .
Yeast   351 VFSFL------HMHPRI-------------------ITNEIDP-----KDNLGVLLIEFFELYGK 385

  Fly  1225 TFDFRNFAISIRTG--GVLPVSTCRMAKSPKNDVYQWKELNIEEPFDLSN 1272
            .|.:.:.|:....|  ...|.||....:..||..    .|.|::|.|.||
Yeast   386 NFGYDDVALGSSDGYPVYFPKSTWSAIQPIKNPF----SLAIQDPGDESN 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wisp	NP_001285144.1	NT_PAP_TUTase	987..1122	CDD:143392	29/140 (21%)
wisp	NP_001285144.1	PAP_assoc	1211..1272	CDD:281779	18/63 (29%)
PAP2	NP_014526.1	TRF4	116..584	CDD:227585	76/385 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810