DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wisp and TUT7

DIOPT Version :9

Sequence 1:	NP_001285144.1	Gene:	wisp / 32152	FlyBaseID:	FBgn0260780	Length:	1373	Species:	Drosophila melanogaster
Sequence 2:	XP_011517313.1	Gene:	TUT7 / 79670	HGNCID:	25817	Length:	1551	Species:	Homo sapiens

Alignment Length:	336	Identity:	95/336 - (28%)
Similarity:	158/336 - (47%)	Gaps:	64/336 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly  1008 FERYRICLVGSTITGFGTDSSDIDMCLLPEQGVHPHQHQYHQHHHFHNEKRTEAL----IILTLF 1068
            |...::.|.||:..|||...||:|:|:.                 .:..:..|.|    .|..|.
Human  1037 FPGTKLSLFGSSKNGFGFKQSDLDVCMT-----------------INGLETAEGLDCVRTIEELA 1084

  Fly  1069 NAVLKDTEVFQDFNLIEARVPILRFKDISNGIEVDLNFNNCVGIKNTYLLQLYAQMDWRTRPLVV 1133
            ..:.|.:.:.....:..|:|||::|..:.:|:|||::..|.:.:.||.||..|:.:|.|.:.|..
Human  1085 RVLRKHSGLRNILPITTAKVPIVKFFHLRSGLEVDISLYNTLALHNTRLLSAYSAIDPRVKYLCY 1149

  Fly  1134 IVKLWAQYHDINDAKRMTISSYSLVLMVLHYLQHACVPHVLPCLHSLY-----PEKFQLGQQDCL 1193
            .:|::.:..||.||.|.::|||:..||||::||.. .|.|:|.|..:|     ||.|..| .:..
Human  1150 TMKVFTKMCDIGDASRGSLSSYAYTLMVLYFLQQR-NPPVIPVLQEIYKGEKKPEIFVDG-WNIY 1212

  Fly  1194 DLDLIEPIEPYQA---LNTQTLGEHLLGFFKYYS-TFDFRNFAISIRTGGVLPVSTCRMAKSPKN 1254
            ..|.|:.:..|.:   .||:::|:..||..::|: .|||:...||||...:|  :|.:.
Human  1213 FFDQIDELPTYWSECGKNTESVGQLWLGLLRFYTEEFDFKEHVISIRRKSLL--TTFKK------ 1269

  Fly  1255 DVYQW--KELNIEEPFDLSNTARSVYDGPTFERVKAVFL----ISARRLDHTLDLATIFR-PIHH 1312
               ||  |.:.||:||||::..     |....|....|:    |:.||         :|. |:..
Human  1270 ---QWTSKYIVIEDPFDLNHNL-----GAGLSRKMTNFIMKAFINGRR---------VFGIPVKG 1317

  Fly  1313 VPEHFPQLQQH 1323
            .|:.:|...::
Human  1318 FPKDYPSKMEY 1328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wisp	NP_001285144.1	NT_PAP_TUTase	987..1122	CDD:143392	30/117 (26%)
wisp	NP_001285144.1	PAP_assoc	1211..1272	CDD:281779	22/63 (35%)
TUT7	XP_011517313.1	NT_PAP_TUTase	315..427	CDD:143392
		PAP_assoc	550..599	CDD:281779
		NT_PAP_TUTase	1021..1138	CDD:143392	30/117 (26%)
		PAP_assoc	1233..1286	CDD:281779	22/63 (35%)
		TUTF7_u4	1371..1450	CDD:293237
		ZnF_C2HC	1452..1468	CDD:197667
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R202
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840