DRSC/TRiP Functional Genomics Resources

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Protein Alignment wisp and Tut1

DIOPT Version :9

Sequence 1:NP_001285144.1 Gene:wisp / 32152 FlyBaseID:FBgn0260780 Length:1373 Species:Drosophila melanogaster
Sequence 2:NP_932110.1 Gene:Tut1 / 70044 MGIID:1917294 Length:869 Species:Mus musculus


Alignment Length:641 Identity:130/641 - (20%)
Similarity:230/641 - (35%) Gaps:229/641 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   857 ISPTPSALGSAQLSPH-----------------------LAEMRVQHPLHQQHPPSHASHRPHGQ 898
            :|..|..:||||||.:                       :.::..:..:..|  |.|:       
Mouse    60 VSGFPRDVGSAQLSEYFQTFGPVANIVMDKDKGVFAIVEMGDISAREAVLSQ--PKHS------- 115

  Fly   899 MGGHAMSSYVPHRPPPPPHPSISSP-NPTPVATGAGGPWYEMILPPDRYLAQARNIEVTVQPEKL 962
            :|||.:      |..|.......|| :.:|  .|.....::::    :.||:|  .:|..|..||
Mouse   116 LGGHGL------RVRPREQKEFQSPASKSP--KGVDSSSHQLV----QALAEA--ADVGAQMVKL 166

  Fly   963 ICMCKYDNLSAEIWKRFRGAQQTHNKFKLKMRLWRYLYLWMHQPMF-ERYRICLV---GSTITGF 1023
            :          |:.:.....:|..|           |.:.:.|.:| |.:..|:|   |||:..|
Mouse   167 V----------ELRELSEAERQLRN-----------LVVALMQEVFTEFFPGCVVHPFGSTVNSF 210

  Fly  1024 GTDSSDIDMCL----------------LPE-------------------------QGVHPHQHQY 1047
            .....|:|:.|                :||                         ..:.|...|.
Mouse   211 DVHGCDLDLFLDMGDMEETEPDPKAPKVPETSSLDSALASSLDPQALACTPASPLDSLSPTSVQE 275

  Fly  1048 HQHHHF---------------------------------------------------HNEKRTEA 1061
            .:...|                                                   ..:::.||
Mouse   276 SESLDFDTPSSLAPQTPDSALGSDTVTSPQSLPPVSPLQEDRKEGKQGKELELAEEASKDEKEEA 340

  Fly  1062 LIILTLFNAVLKD--TEVFQDFNLIEARVPILRFKDISNGIEVDLNFNNCVGIKNTYLLQLYAQM 1124
            ..:|.|..::|:.  ..|::...:..||.|:::|....:|:..|::.:|.:.:.|:..|.|.::|
Mouse   341 AAVLELVGSILRGCVPGVYRVQTVPSARRPVVKFCHRPSGLHGDVSLSNRLALYNSRFLNLCSEM 405

  Fly  1125 DWRTRPLVVIVKLWAQYHDINDAKRMTISSYSLVLMVLHYLQHACVPHVLPCLHSLYP-----EK 1184
            |.|.||||..::.|||::.::....: :::|:|.|:|:::|| ...|.|||.:..|..     |:
Mouse   406 DGRVRPLVYTLRCWAQHNGLSGGGPL-LNNYALTLLVIYFLQ-TRDPPVLPTVAQLTQRAGEGEQ 468

  Fly  1185 FQLGQQDC---LDLDLIEPIEPYQALNTQTLGEHLLGFFKYYSTFDFRNFAISIRTGGVLPVSTC 1246
            .::...||   .|...:||     :.|.:.|...|..||...|..|.....:|:|.|..|.|   
Mouse   469 VEVDGWDCSFPKDASRLEP-----STNVEPLSSLLAQFFSCVSCLDLSGSLLSLREGRPLMV--- 525

  Fly  1247 RMAKSPKNDVYQWKEL---NIEEPFDLSNTARSVYDGPTFERVKAVFLISARRLDHTLDLATIF- 1307
              |:...:|:::...|   |:::|||||:...:...|    ||       |:||......|..: 
Mouse   526 --AEGLPSDLWEGLRLGPMNLQDPFDLSHNVAANVTG----RV-------AKRLQSCCGAAASYC 577

  Fly  1308 RPIHHVPEHFPQLQQHQQQFEQQLHHPISGQQRSAGGGGDGANPVPSTLNPDAAST 1363
            |.:.:                         ||||:.|...|..|:   |.|.:.|:
Mouse   578 RSLQY-------------------------QQRSSRGRDWGLLPL---LQPSSPSS 605

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wispNP_001285144.1 NT_PAP_TUTase 987..1122 CDD:143392 35/232 (15%)
PAP_assoc 1211..1272 CDD:281779 19/63 (30%)
Tut1NP_932110.1 ZnF_U1 14..47 CDD:197732
RRM_TUT1 54..127 CDD:240725 16/81 (20%)
RRM <56..>140 CDD:223796 19/96 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..144 10/44 (23%)
NT_PAP_TUTase 179..403 CDD:143392 35/234 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 226..247 2/20 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 259..335 3/75 (4%)
KA1, binds the bulging loops of U6 snRNA but is dispensable for terminal uridylyltransferase activity. /evidence=ECO:0000250|UniProtKB:Q9H6E5 601..869 1/5 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 640..689
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 735..757
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 775..796
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 803..822
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5260
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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