DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wisp and Trf4-1

DIOPT Version :9

Sequence 1:	NP_001285144.1	Gene:	wisp / 32152	FlyBaseID:	FBgn0260780	Length:	1373	Species:	Drosophila melanogaster
Sequence 2:	NP_001259340.1	Gene:	Trf4-1 / 31795	FlyBaseID:	FBgn0030049	Length:	1001	Species:	Drosophila melanogaster

Alignment Length:	1116	Identity:	201/1116 - (18%)
Similarity:	317/1116 - (28%)	Gaps:	454/1116 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SQQLEFRTRMSAGSPSSKSGQCHLKFGKYNNKTANLLRQVNSCHSSNSSSNTSNNNNEAIKGQQQ 99
            :|||:..|.::..:.||.|                         ||||.:|.:||||..|    .
  Fly    36 NQQLQQATTINGSTSSSSS-------------------------SSNSGNNNNNNNNNII----N 71

  Fly   100 QPLHYCNSNNSHSWARKKYFGNGNSN-NSLLQQQQQPSSFFQRQQQQHQMQMQQEKQATNNNDAL 163
            ..:....:|..::.:.|.|.....|: |.:|..:.......|:||||.|:....::.:||.|
  Fly    72 NTITNTTNNTGNNSSAKPYLSRPYSSLNRVLNFRADSLEILQQQQQQQQLNGTTQRNSTNIN--- 133

  Fly   164 MKNQNVVNAHVSDCKSSDSNNNSTSSSNNNSTISSNNNNTSSASNNNTGSSSSCSNRTKPAKWLN 228
                             .::..|||||.:::|...||:..:|:|.|..|:.:..|.   .|....
  Fly   134 -----------------TTSGGSTSSSADSTTNRDNNSPANSSSTNGPGAGTGTST---GAGGTG 178

  Fly   229 ENSSSSSSSNNNNISCRNNNTSSIDTKRRNSSAGATAAYYRKSESESGSSEGAAESTETEATRTG 293
            .||.::::|                     |:|..|..   .:.|.|.:|....:||.|.|:||.
  Fly   179 TNSPATTAS---------------------STAATTTG---PATSMSDTSNNPPQSTTTPASRTN 219

  Fly   294 GC--NSNRTAESSSADGGTQATMGKSQDQEQDQTVKQRPRQQP---------------------- 334
            ..  |.:|.....:..||....|  :...|.....|..|.::|
  Fly   220 SIYYNPSRKKRPENKAGGAHYYM--NNHMEMIAKYKGEPWRKPDYPYGEGVIGLHEEIEHFYQYV 282

  Fly   335 ---------------------LSFWKTNYPQ----------------TSATQL------------ 350
                                 .|.|    ||                ||...|
  Fly   283 LPTPCEHAIRNEVVKRIEAVVHSIW----PQAVVEIFGSFRTGLFLPTSDIDLVVLGLWEKLPLR 343

  Fly   351 -KDKETVAAVVSAAAVAAAAAAASAS----EQQQQQQSLSIEHRRNSGYQQHQQHNYYPYYYSQP 410
             .:.|.|:..::.|........||..    ..::.|..:.|.....||.|..:....:...|...
  Fly   344 TLEFELVSRGIAEACTVRVLDKASVPIIKLTDRETQVKVDISFNMQSGVQSAELIKKFKRDYPVL 408

  Fly   411 KQLTIA----------------------------SFLQKEMLPDSTEKSSSNTG----------- 436
            ::|.:.                            ||||  |.|......::|.|
  Fly   409 EKLVLVLKQFLLLRDLNEVFTGGISSYSLILMCISFLQ--MHPRGIYHDTANLGVLLLEFFELYG 471

  Fly   437 -GSNMIR---SSSNGNSNFSRHQY------GHQ-----------------STGSGYQQQQQRYRN 474
             ..|.::   |..||.....:.:.      ||:                 .:..|..|.||.::.
  Fly   472 RRFNYMKIGISIKNGGRYMPKDELQRDMVDGHRPSLLCIEDPLTPGNDIGRSSYGVFQVQQAFKC 536

  Fly   475 AQNVY--------------------------------------QQYQH----------------- 484
            |..|.                                      :.::|
  Fly   537 AYRVLALAVSPLNLLGIDPRVNSILGRIIHITDDVIDYREWIRENFEHLVVVDRISPLPTAAPTA 601

  Fly   485 --------------------QQQHHAQQ----HTHPHFRRKHSDNGSGINKKMHYSPPGKSGDPA 525
                                |..||..|    |.|.|   .||.:....:...|...|..:|...
  Fly   602 YATANGAPKYVIMPSGAVVQQLYHHPVQVPTAHGHSH---AHSHSHGHAHPGAHLCQPYVTGTTV 663

  Fly   526 DR--------------SASGQQQHH-------HPHQQQKTIEILASSHFNAMHRRMQGGNNKNGY 569
            ..              ||.|.||..       |.|.||:|     .:...:.|||
  Fly   664 SAVTTTTTMAVVTVGVSAGGVQQQQQQQNATAHTHSQQQT-----QNQSQSRHRR---------- 713

  Fly   570 YQHSYNPMTGEVGSTPTRSEHQNIYNLTYIHVDTEATGEAASAAGSTPVVKPSLLSKPNISITPA 634
                        |||.:..:.::           ...|:......|...|....||.||   ..|
  Fly   714 ------------GSTSSGDDSED-----------SKDGDVVETTSSAQEVVDIALSTPN---GLA 752

  Fly   635 SSTTPTTVDRALLPAVRSVSAPASGSALPAPAN-------HVRNMFPPPPL----------AMLG 682
            :.:.|..|....:||..|.|...:|:...:.:.       |:......|.|          ...|
  Fly   753 NMSMPMPVHAVGMPASNSWSGNGNGNGNSSSSTGSSPEIAHIAAQEMDPELEDQQQQQQHQETSG 817

  Fly   683 GHGLLSPVTTTTPTKMISCAQLDEAITAAAASGDKLSTSPSYNQAG-----------HYIMPPQQ 736
            |:|.:.|               .:..|.:...|...|...:|||..           :|:.||.|
  Fly   818 GNGFIRP---------------GDVGTGSNRGGGDGSGGRNYNQRNNHNSSGYYHQQYYVPPPMQ 867

  Fly   737 QQQQQLSSHPIPTGTSSHPPPPPPPHMFFHFADGFCNPGQGHQAPPATMWPHSSSP--------- 792
            ||..:.:|      :|::       |...|.:....|.....|........|...|
  Fly   868 QQLSKSNS------SSNY-------HQQHHHSHSHGNHSHRQQHHHQQQHHHQQRPQHLRVGGGN 919

  Fly   793 CYPASYGS----SCGSGTGAGTSPHNNDGNAGA----LRP-------ASPALSSSSLGSESQ-WS 841
            .|..|.|.    |.|:.:.:.::..|:..::|:    |.|       :|.|:|..|:.|||. .|
  Fly   920 RYQKSLGGSPIISAGNASNSSSNCSNSSSSSGSNNSRLPPLRGTLVNSSSAISIISISSESSIAS 984

  Fly   842 GTSNRSRLGHN 852
            .:|:.||.|.:
  Fly   985 SSSSSSRSGQD 995

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wisp	NP_001285144.1	NT_PAP_TUTase	987..1122	CDD:143392
wisp	NP_001285144.1	PAP_assoc	1211..1272	CDD:281779
Trf4-1	NP_001259340.1	NT_PAP_TUTase	291..401	CDD:143392	17/113 (15%)
Trf4-1	NP_001259340.1	PAP_assoc	458..518	CDD:281779	8/59 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810