DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wisp and TUT4

DIOPT Version :9

Sequence 1:	NP_001285144.1	Gene:	wisp / 32152	FlyBaseID:	FBgn0260780	Length:	1373	Species:	Drosophila melanogaster
Sequence 2:	XP_005270733.1	Gene:	TUT4 / 23318	HGNCID:	28981	Length:	1652	Species:	Homo sapiens

Alignment Length:	361	Identity:	107/361 - (29%)
Similarity:	174/361 - (48%)	Gaps:	56/361 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   962 LICMCKYDNLSAEIWKRFRGAQQTHNKFKLKMRLWRYLYLWMHQPMFERYRICLVGSTITGFGTD 1026
            |:|...:|.||..       ..:.||:.::.:.|.:::    .:...|:.|:||.||:..|||..
Human   953 LVCKRCFDELSPP-------CSEQHNREQILIGLEKFI----QKEYDEKARLCLFGSSKNGFGFR 1006

  Fly  1027 SSDIDMCLLPEQGVHPHQHQYHQHHHFHNEKRTEALIILTLFNAVLKDTEVFQDFNLIEARVPIL 1091
            .||:|:|:..|             .|.:.||.....||..|...:.:...:.....:..|:|||:
Human  1007 DSDLDICMTLE-------------GHENAEKLNCKEIIENLAKILKRHPGLRNILPITTAKVPIV 1058

  Fly  1092 RFKDISNGIEVDLNFNNCVGIKNTYLLQLYAQMDWRTRPLVVIVKLWAQYHDINDAKRMTISSYS 1156
            :|:...:|:|.|::..|.:...||.:|..||.:|.|.:.|...:|::|:..||.||.|.::|||:
Human  1059 KFEHRRSGLEGDISLYNTLAQHNTRMLATYAAIDPRVQYLGYTMKVFAKRCDIGDASRGSLSSYA 1123

  Fly  1157 LVLMVLHYLQHACVPHVLPCLHSLYPEKFQLGQQ-----DCLDLDLIEPIE---PYQALNTQTLG 1213
            .:||||::||.. .|.|:|.|..::..| |:.|:     :....|..|.::   |....||::||
Human  1124 YILMVLYFLQQR-KPPVIPVLQEIFDGK-QIPQRMVDGWNAFFFDKTEELKKRLPSLGKNTESLG 1186

  Fly  1214 EHLLGFFKYYS-TFDFRNFAISIRTGGVLPVSTCRMAKSPKNDVYQW--KELNIEEPFDLS-NTA 1274
            |..||..::|: .|||:.:.||||...:|....           .||  |.:.||:||||: |..
Human  1187 ELWLGLLRFYTEEFDFKEYVISIRQKKLLTTFE-----------KQWTSKCIAIEDPFDLNHNLG 1240

  Fly  1275 RSVYDGPTFERVKAVFLISARRLDHTLDLATIFRPI 1310
            ..|....|...:||  .|:.|:|     ..|.|.|:
Human  1241 AGVSRKMTNFIMKA--FINGRKL-----FGTPFYPL 1269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wisp	NP_001285144.1	NT_PAP_TUTase	987..1122	CDD:143392	34/134 (25%)
wisp	NP_001285144.1	PAP_assoc	1211..1272	CDD:281779	23/64 (36%)
TUT4	XP_005270733.1	NT_PAP_TUTase	375..487	CDD:143392
		PAP_assoc	628..677	CDD:281779
		NT_PAP_TUTase	971..1089	CDD:143392	34/134 (25%)
		PAP_assoc	1184..1237	CDD:281779	23/63 (37%)
		PTZ00368	<1280..1375	CDD:173561
		CytochromB561_N	1375..>1516	CDD:286826
		DUF1421	<1383..1650	CDD:284607
		FAM75	1423..>1484	CDD:291323
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810