DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wisp and Tut4

DIOPT Version :9

Sequence 1:	NP_001285144.1	Gene:	wisp / 32152	FlyBaseID:	FBgn0260780	Length:	1373	Species:	Drosophila melanogaster
Sequence 2:	XP_036019916.1	Gene:	Tut4 / 230594	MGIID:	2445126	Length:	1660	Species:	Mus musculus

Alignment Length:	1488	Identity:	283/1488 - (19%)
Similarity:	494/1488 - (33%)	Gaps:	518/1488 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 MQQEKQATNNNDALMKNQNVVNAHVSDCKSSDS----NNNSTSSSNNNSTI--SSNNNNTSSASN 208
            |::.|.:.|.|....|  |::      |:.|.:    :|.:....|:.|.|  ||.|.|:|..:.
Mouse     1 MEEPKTSKNENHEPKK--NII------CEESKAVKIISNQTLKPRNDKSEIGTSSLNRNSSKKTK 57

  Fly   209 NNTGSSSSCSNRTKPAKWLNENSSSSSSSNNNNISCRNNNTSSIDTKRRNSSAGATAAYYRKSES 273
            .|    ..|..:|: ||....|::|.....:..:..|:.:...: .|..||          ..::
Mouse    58 QN----DICIEKTE-AKSCKVNAASVPGPKDLGLVHRDQSHCKM-KKLPNS----------PMKA 106

  Fly   274 ESGSSEGAAESTETEATRTGGCNSN-------RTAESSSADGGTQATMGKSQDQEQDQTVKQR-- 329
            :.|||:...|.|.:..|:......:       ..|..::|:..|:..:...:.:|...|.:.:
Mouse   107 QKGSSQTKLEKTPSLQTKAEKVPKSPNLPVKAEKAPCTTAEATTEKALNSQRKEENTPTSQMKLQ 171

  Fly   330 --------PRQQPLSFWKTNYPQTSATQLKDKETVAAVVSAAAVAAAAAAASASEQQQQQQSLSI 386
                    |...|....|.|..||.:.|...|.|.:.|         :.....||..|.::| ::
Mouse   172 KTPRSPLEPENVPSLLLKENVKQTESQQTGKKLTSSFV---------SMDKRKSEALQGEKS-AL 226

  Fly   387 EHRRNSGYQQHQQHNYYPYYYSQPKQLTIASFLQKEMLPDSTEKSS---SNTGGSNMIRSSSNGN 448
            |   ||...|.||                   .|.:.:.||.:.:|   ......:.::|..:..
Mouse   227 E---NSSLSQKQQ-------------------TQTDNIADSDDSASGIEDTADDLSKMKSEESNK 269

  Fly   449 SNFSRHQYGHQST-----------GSGYQQQQQRYRNAQNVYQQYQHQQQHHAQQHTHPHFRRK- 501
            .|.|...|...:|           ..|.:|.::|      :.:.:..:.:..:.::|:..:..|
Mouse   270 ENSSEMDYLENATVIDESALTPEQRLGLKQAEER------LERDHIFRLEKRSPEYTNCRYLCKL 328

  Fly   502 ---HSDNGSGINKKMHYSPPGKSGDPADRSASGQQQHHHPH----QQQKTIEIL---ASSHFNAM 556
               |.:|..|.:|.:                  :::.|..:    |::..:..|   :|:|..|:
Mouse   329 CLIHIENIQGAHKHI------------------KEKRHKKNILEKQEESELRSLPSPSSAHLAAL 375

  Fly   557 H------RRMQGGNNKNGYYQHSYNPMTGEV-------------GST-----------------P 585
            .      .:.||..:.:...:........:|             ||:                 |
Mouse   376 SVAVVELAKEQGITDDDLRIRQDIVEEMSKVIMTFLPECSLRLYGSSLTKFALKSSDVNIDIKFP 440

  Fly   586 TRSEHQN-------IYNLTYIHVDTEATGEAASAAGSTPVV-----KPSLLSKPNISITPASSTT 638
            .:..|.:       |...:.:::|.|:...|     ..|||     |.:||.:.:.....|..||
Mouse   441 PKMNHPDLLIQVLGILKKSALYIDVESDFHA-----KVPVVVCKDRKSALLCRVSAGNDMACLTT 500

  Fly   639 PTTVDRALLPAVRSVSAP----------------ASGSALPAPANHVRNMF-----PPPPLAMLG 682
            ...   |.|..|..|..|                .:...:|:....:..||     .||.|..|.
Mouse   501 DLL---AALGKVEPVFTPLVLAFRYWAKLCYIDSQTDGGIPSYCFALMVMFFLQQRKPPLLPCLL 562

  Fly   683 G---------------------------------------------------------------- 683
            |
Mouse   563 GSWIEGFDPKRMDDFQLKGIVEEKFVKWEYNSSSATEKNLIADENKAKADEPKDDTKKTETDNQS 627

  Fly   684 ------HGLLSPVTTTTPTKM----------------------ISCAQLDEAIT--------AAA 712
                  || .||:|...|.::                      :.|.::.:.:|        ...
Mouse   628 NAAKAKHG-KSPLTLEAPNQVPLGQLWLELLKFYTLDFALEEYVICVRIQDILTRENKNWPKRRI 691

  Fly   713 ASGDKLSTSPS-----------------YNQAGHYI------------MPPQQQQQQQLSS-HPI 747
            |..|..|...:                 :..|..|.            |.|:::::.:||| .|:
Mouse   692 AIEDPFSVKRNVARSLNSQLVYEYVVERFRAAYRYFACPQKKGGNKSTMDPKKKEKGKLSSKKPV 756

  Fly   748 PTGTSSHPPPPPPPHMFFHFADGFCNPGQG------HQAPPATMWPH-----SSSPCYP------ 795
            .:..|               |...|..|:.      .:..||   .|     :|..|..
Mouse   757 KSDCS---------------ATNCCILGESAEKIHMERGQPA---KHDETEFTSQRCIVDNDSLL 803

  Fly   796 ------ASYG---SSCGSGTGAGTSPHNNDGNAGALRPASPALS---------SSSLGSESQWSG 842
                  |::|   ||..:.:|.......:....|.|.|:..:|.         .:..|:||  :|
Mouse   804 VNELGLANHGQDSSSLSTASGGSDLKQKSAEKQGDLTPSETSLKKELSQCICIGTPDGAES--AG 866

  Fly   843 TSNRSRLG-HNGHP----SISPTPSALGSAQLSPHLAEMRVQHPLHQQHPPSHASHRPHGQMGGH 902
            |..||.|. .:.|.    ::|.|.....:.:::..|.:        :.:.||...:        :
Mouse   867 TDCRSNLEMDSSHQIVCNNVSATSCNCKATEVTSDLVD--------EDNLPSQELY--------Y 915

  Fly   903 AMSSYVPHRPPPPP----------HPSISSP--------NPTPVATGAGGPWYEMILPPDRYLAQ 949
            ....::.....||.          |.....|        .|.|..|..    :..||
Mouse   916 VFDKFILTSGKPPTIVCSICKKDGHSKNDCPEDFRKIDLKPLPPMTNR----FREIL-------- 968

  Fly   950 ARNIEVTVQPEKLICMCKYDNLSAEIWKRFRGAQQTHNKFKLKMRLWRYLYLWMHQPMFERYRIC 1014
                       .|:|...:|.||..       ..:.||:.::.:.|.:::    .:...|:.|:|
Mouse   969 -----------DLVCKRCFDELSPP-------CSEQHNREQILIGLEKFI----QKEYDEKARLC 1011

  Fly  1015 LVGSTITGFGTDSSDIDMCLLPEQGVHPHQHQYHQHHHFHNEKRTEALIILTLFNAVLKDTEVFQ 1079
            |.||:..|||...||:|:|:..|             .|.:.||.....||..|...:.:...:..
Mouse  1012 LFGSSKNGFGFRDSDLDICMTLE-------------GHENAEKLNCKEIIENLAKILKRHPGLRN 1063

  Fly  1080 DFNLIEARVPILRFKDISNGIEVDLNFNNCVGIKNTYLLQLYAQMDWRTRPLVVIVKLWAQYHDI 1144
            ...:..|:|||::|:...:|:|.|::..|.:...||.:|..||.:|.|.:.|...:|::|:..||
Mouse  1064 ILPITTAKVPIVKFEHRRSGLEGDISLYNTLAQHNTRMLATYAAIDPRVQYLGYTMKVFAKRCDI 1128

  Fly  1145 NDAKRMTISSYSLVLMVLHYLQHACVPHVLPC------LHSLYPEKFQLGQQ---------DCLD 1194
            .||.|.::|||:.:||||::||.. .|.|:|.      |..:.|.:...|:|         :...
Mouse  1129 GDASRGSLSSYAYILMVLYFLQQR-KPPVIPVLQEQINLEDIIPNEIFDGKQIPQRMVDGWNAFF 1192

  Fly  1195 LDLIEPIE---PYQALNTQTLGEHLLGFFKYYS-TFDFRNFAISIRTGGVLPVSTCRMAKSPKND 1255
            .|..|.::   |....||::|||..||..::|: .|||:.:.||||...:|....
Mouse  1193 FDKTEELKKRLPSLGKNTESLGELWLGLLRFYTEEFDFKEYVISIRQKKLLTTFE---------- 1247

  Fly  1256 VYQW--KELNIEEPFDLS-NTARSVYDGPTFERVKAVFLISARRLDHTLDLATIFRPI 1310
             .||  |.:.||:||||: |....|....|...:||  .|:.|:|     ..|.|.|:
Mouse  1248 -KQWTSKCIAIEDPFDLNHNLGAGVSRKMTNFIMKA--FINGRKL-----FGTPFYPL 1297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wisp	NP_001285144.1	NT_PAP_TUTase	987..1122	CDD:143392	34/134 (25%)
wisp	NP_001285144.1	PAP_assoc	1211..1272	CDD:281779	23/64 (36%)
Tut4	XP_036019916.1	rad2	<2..>366	CDD:273166	79/443 (18%)
		TUTase	285..621	CDD:408858	48/367 (13%)
		PAP_assoc	648..697	CDD:397761	4/48 (8%)
		TRF4	946..>1289	CDD:227585	109/403 (27%)
		NT_PAP_TUTase	988..1106	CDD:143392	34/134 (25%)
		AIR1	<1304..>1393	CDD:227414
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5260
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810