Protein Alignment wisp and Tut4

DIOPT Version :10

• Sequence 1: NP_572766.1
• Gene: wisp / 32152
• FlyBaseID: FBgn0260780
• Length: 1373
• Species: Drosophila melanogaster
• Sequence 2: XP_036019916.1
• Gene: Tut4 / 230594
• MGIID: 2445126
• Length: 1660
• Species: Mus musculus
• Alignment Length: 1488
• Identity: 283/1488 - (19%)
• Similarity: 494/1488 - (33%)
• Gaps: 518/1488 - (34%)

  Fly   150 MQQEKQATNNNDALMKNQNVVNAHVSDCKSSDS----NNNSTSSSNNNSTI--SSNNNNTSSASN 208
            |::.|.:.|.|....|  |::      |:.|.:    :|.:....|:.|.|  ||.|.|:|..:.
Mouse     1 MEEPKTSKNENHEPKK--NII------CEESKAVKIISNQTLKPRNDKSEIGTSSLNRNSSKKTK 57

  Fly   209 NNTGSSSSCSNRTKPAKWLNENSSSSSSSNNNNISCRNNNTSSIDTKRRNSSAGATAAYYRKSES 273
            .|    ..|..:|: ||....|::|.....:..:..|:.:...: .|..||          ..::
Mouse    58 QN----DICIEKTE-AKSCKVNAASVPGPKDLGLVHRDQSHCKM-KKLPNS----------PMKA 106

  Fly   274 ESGSSEGAAESTETEATRTGGCNSN-------RTAESSSADGGTQATMGKSQDQEQDQTVKQR-- 329
            :.|||:...|.|.:..|:......:       ..|..::|:..|:..:...:.:|...|.:.:
Mouse   107 QKGSSQTKLEKTPSLQTKAEKVPKSPNLPVKAEKAPCTTAEATTEKALNSQRKEENTPTSQMKLQ 171

  Fly   330 --------PRQQPLSFWKTNYPQTSATQLKDKETVAAVVSAAAVAAAAAAASASEQQQQQQSLSI 386
                    |...|....|.|..||.:.|...|.|.:.|         :.....||..|.::| ::
Mouse   172 KTPRSPLEPENVPSLLLKENVKQTESQQTGKKLTSSFV---------SMDKRKSEALQGEKS-AL 226

  Fly   387 EHRRNSGYQQHQQHNYYPYYYSQPKQLTIASFLQKEMLPDSTEKSS---SNTGGSNMIRSSSNGN 448
            |   ||...|.||                   .|.:.:.||.:.:|   ......:.::|..:..
Mouse   227 E---NSSLSQKQQ-------------------TQTDNIADSDDSASGIEDTADDLSKMKSEESNK 269

  Fly   449 SNFSRHQYGHQST-----------GSGYQQQQQRYRNAQNVYQQYQHQQQHHAQQHTHPHFRRK- 501
            .|.|...|...:|           ..|.:|.::|      :.:.:..:.:..:.::|:..:..|
Mouse   270 ENSSEMDYLENATVIDESALTPEQRLGLKQAEER------LERDHIFRLEKRSPEYTNCRYLCKL 328

  Fly   502 ---HSDNGSGINKKMHYSPPGKSGDPADRSASGQQQHHHPH----QQQKTIEIL---ASSHFNAM 556
               |.:|..|.:|.:                  :::.|..:    |::..:..|   :|:|..|:
Mouse   329 CLIHIENIQGAHKHI------------------KEKRHKKNILEKQEESELRSLPSPSSAHLAAL 375

  Fly   557 H------RRMQGGNNKNGYYQHSYNPMTGEV-------------GST-----------------P 585
            .      .:.||..:.:...:........:|             ||:                 |
Mouse   376 SVAVVELAKEQGITDDDLRIRQDIVEEMSKVIMTFLPECSLRLYGSSLTKFALKSSDVNIDIKFP 440

  Fly   586 TRSEHQN-------IYNLTYIHVDTEATGEAASAAGSTPVV-----KPSLLSKPNISITPASSTT 638
            .:..|.:       |...:.:::|.|:...|     ..|||     |.:||.:.:.....|..||
Mouse   441 PKMNHPDLLIQVLGILKKSALYIDVESDFHA-----KVPVVVCKDRKSALLCRVSAGNDMACLTT 500

  Fly   639 PTTVDRALLPAVRSVSAP----------------ASGSALPAPANHVRNMF-----PPPPLAMLG 682
            ...   |.|..|..|..|                .:...:|:....:..||     .||.|..|.
Mouse   501 DLL---AALGKVEPVFTPLVLAFRYWAKLCYIDSQTDGGIPSYCFALMVMFFLQQRKPPLLPCLL 562

  Fly   683 G---------------------------------------------------------------- 683
            |
Mouse   563 GSWIEGFDPKRMDDFQLKGIVEEKFVKWEYNSSSATEKNLIADENKAKADEPKDDTKKTETDNQS 627

  Fly   684 ------HGLLSPVTTTTPTKM----------------------ISCAQLDEAIT--------AAA 712
                  || .||:|...|.::                      :.|.::.:.:|        ...
Mouse   628 NAAKAKHG-KSPLTLEAPNQVPLGQLWLELLKFYTLDFALEEYVICVRIQDILTRENKNWPKRRI 691

  Fly   713 ASGDKLSTSPS-----------------YNQAGHYI------------MPPQQQQQQQLSS-HPI 747
            |..|..|...:                 :..|..|.            |.|:::::.:||| .|:
Mouse   692 AIEDPFSVKRNVARSLNSQLVYEYVVERFRAAYRYFACPQKKGGNKSTMDPKKKEKGKLSSKKPV 756

  Fly   748 PTGTSSHPPPPPPPHMFFHFADGFCNPGQG------HQAPPATMWPH-----SSSPCYP------ 795
            .:..|               |...|..|:.      .:..||   .|     :|..|..
Mouse   757 KSDCS---------------ATNCCILGESAEKIHMERGQPA---KHDETEFTSQRCIVDNDSLL 803

  Fly   796 ------ASYG---SSCGSGTGAGTSPHNNDGNAGALRPASPALS---------SSSLGSESQWSG 842
                  |::|   ||..:.:|.......:....|.|.|:..:|.         .:..|:||  :|
Mouse   804 VNELGLANHGQDSSSLSTASGGSDLKQKSAEKQGDLTPSETSLKKELSQCICIGTPDGAES--AG 866

  Fly   843 TSNRSRLG-HNGHP----SISPTPSALGSAQLSPHLAEMRVQHPLHQQHPPSHASHRPHGQMGGH 902
            |..||.|. .:.|.    ::|.|.....:.:::..|.:        :.:.||...:        :
Mouse   867 TDCRSNLEMDSSHQIVCNNVSATSCNCKATEVTSDLVD--------EDNLPSQELY--------Y 915

  Fly   903 AMSSYVPHRPPPPP----------HPSISSP--------NPTPVATGAGGPWYEMILPPDRYLAQ 949
            ....::.....||.          |.....|        .|.|..|..    :..||
Mouse   916 VFDKFILTSGKPPTIVCSICKKDGHSKNDCPEDFRKIDLKPLPPMTNR----FREIL-------- 968

  Fly   950 ARNIEVTVQPEKLICMCKYDNLSAEIWKRFRGAQQTHNKFKLKMRLWRYLYLWMHQPMFERYRIC 1014
                       .|:|...:|.||..       ..:.||:.::.:.|.:::    .:...|:.|:|
Mouse   969 -----------DLVCKRCFDELSPP-------CSEQHNREQILIGLEKFI----QKEYDEKARLC 1011

  Fly  1015 LVGSTITGFGTDSSDIDMCLLPEQGVHPHQHQYHQHHHFHNEKRTEALIILTLFNAVLKDTEVFQ 1079
            |.||:..|||...||:|:|:..|             .|.:.||.....||..|...:.:...:..
Mouse  1012 LFGSSKNGFGFRDSDLDICMTLE-------------GHENAEKLNCKEIIENLAKILKRHPGLRN 1063

  Fly  1080 DFNLIEARVPILRFKDISNGIEVDLNFNNCVGIKNTYLLQLYAQMDWRTRPLVVIVKLWAQYHDI 1144
            ...:..|:|||::|:...:|:|.|::..|.:...||.:|..||.:|.|.:.|...:|::|:..||
Mouse  1064 ILPITTAKVPIVKFEHRRSGLEGDISLYNTLAQHNTRMLATYAAIDPRVQYLGYTMKVFAKRCDI 1128

  Fly  1145 NDAKRMTISSYSLVLMVLHYLQHACVPHVLPC------LHSLYPEKFQLGQQ---------DCLD 1194
            .||.|.::|||:.:||||::||.. .|.|:|.      |..:.|.:...|:|         :...
Mouse  1129 GDASRGSLSSYAYILMVLYFLQQR-KPPVIPVLQEQINLEDIIPNEIFDGKQIPQRMVDGWNAFF 1192

  Fly  1195 LDLIEPIE---PYQALNTQTLGEHLLGFFKYYS-TFDFRNFAISIRTGGVLPVSTCRMAKSPKND 1255
            .|..|.::   |....||::|||..||..::|: .|||:.:.||||...:|....
Mouse  1193 FDKTEELKKRLPSLGKNTESLGELWLGLLRFYTEEFDFKEYVISIRQKKLLTTFE---------- 1247

  Fly  1256 VYQW--KELNIEEPFDLS-NTARSVYDGPTFERVKAVFLISARRLDHTLDLATIFRPI 1310
             .||  |.:.||:||||: |....|....|...:||  .|:.|:|     ..|.|.|:
Mouse  1248 -KQWTSKCIAIEDPFDLNHNLGAGVSRKMTNFIMKA--FINGRKL-----FGTPFYPL 1297

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wisp	NP_572766.1	TRF4	<1017..>1290	CDD:227585	89/294 (30%)
Tut4	XP_036019916.1	rad2	<2..>366	CDD:273166	79/443 (18%)
		TUTase	274..491	CDD:465974	34/245 (14%)
		PAP_assoc	648..697	CDD:427532	4/48 (8%)
		TRF4	946..>1289	CDD:227585	109/403 (27%)
		NT_PAP_TUTase	988..1106	CDD:143392	34/134 (25%)
		AIR1	<1304..>1393	CDD:227414