Protein Alignment HOXB5 and HGTX

DIOPT Version :10

• Sequence 1: NP_002138.1
• Gene: HOXB5 / 3215
• HGNCID: 5116
• Length: 269
• Species: Homo sapiens
• Sequence 2: NP_001368954.1
• Gene: HGTX / 53446
• FlyBaseID: FBgn0040318
• Length: 587
• Species: Drosophila melanogaster
• Alignment Length: 270
• Identity: 70/270 - (25%)
• Similarity: 107/270 - (39%)
• Gaps: 67/270 - (24%)

Human    33 SYRDP--AAMHT----------GSYGYNYNGMDLSVNRSSASSSHFGAVGESSRAFPAPAQEPRF 85
            |:..|  ||:|:          |....:.||:..|.:.:|...|..|:.|.||
  Fly   291 SFLGPPLAALHSMTTEMKGQGVGGSSASANGLSYSHSPNSHLISDRGSGGSSS------------ 343

Human    86 RQAASSCSLSSPESLPCTNGDSHGAKPSASSP---SDQATSASSSANFTEIDEASASSEPEEAAS 147
               :||.:.::..|....|  .||.....|.|   :....||.:.|.......|:|::...:..|
  Fly   344 ---SSSTTTTNTNSQGAPN--PHGIDTILSKPPPVTSAGLSALTGAGIPRFSIAAAAAGMAQYLS 403

Human   148 QLSSPSLARAQPEPMATSTAAPEGQTPQIFP-----------WMRKL-----------HISHDMT 190
            |        :|..|:.|.......:|...:|           |..:|           |..|...
  Fly   404 Q--------SQGAPLKTHAGHIVDRTHLYWPGLQGLVANPIAWRERLSNTMSANLSQSHQHHPSN 460

Human   191 GPDGKR--ARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDN 253
            ..|||:  .|..::..|...|||.|...:||....|.::|:||.:||.|:|:||||||.||:|.:
  Fly   461 DKDGKKKHTRPTFSGQQIFALEKTFEQTKYLAGPERAKLAYALGMSESQVKVWFQNRRTKWRKRH 525

Human   254 KLKSMSLATA 263
               :..:|||
  Fly   526 ---AAEMATA 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXB5	NP_002138.1	PRK07003	<67..>171	CDD:235906	22/106 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..173		18/98 (18%)
		Antp-type hexapeptide	176..181		2/15 (13%)
		Homeodomain	195..251	CDD:459649	25/57 (44%)
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	26/113 (23%)
		Homeodomain	465..523	CDD:459649	25/57 (44%)