Protein Alignment HOXB5 and E5

DIOPT Version :10

• Sequence 1: NP_002138.1
• Gene: HOXB5 / 3215
• HGNCID: 5116
• Length: 269
• Species: Homo sapiens
• Sequence 2: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 357
• Identity: 78/357 - (21%)
• Similarity: 115/357 - (32%)
• Gaps: 150/357 - (42%)

Human    26 SGSSLSGSYRDPAAMHTGSYGYNYNGMDLSVNRSSASS------SHFGAVGESS-RAFP-----A 78
            |.||::.|....:|..|.|              :||||      |....||||| |:.|     .
  Fly    23 SSSSVAASSTSVSASSTVS--------------ASASSKPKLAFSIDSIVGESSTRSAPLRVSVI 73

Human    79 PAQEPRFRQAASSCSLS-----------------------SPESLPCTNGDS---HGAKPSASSP 117
            .:..||....||..:.:                       ||:..|.:...|   .|..|:|:..
  Fly    74 SSPPPRSESPASPTNTNNSGRRTPRGYIYCRRRDSLDRSRSPQRSPVSRSPSPPNAGGNPAAAGN 138

Human   118 SDQATSASS---------------SANFTEIDEASASSEPEEAASQLSSPSLARAQPEP------ 161
            :.::...||               :.|...|...::   |...|.:::.|....:||.|
  Fly   139 TAKSGDPSSGTGNPPTLIRPLPLPAPNLALIGNRTS---PNAMAVRMAGPPHPPSQPPPFLAAQF 200

Human   162 -MATSTA----------------------------APEGQTP----------------------- 174
             ||.:.|                            .|.||.|
  Fly   201 QMAAALAHHHQQQQQQQQQQLPPVPTGPPHGPHPHLPPGQIPLGIFPGGPHPGHPPPHGHHPFGS 265

Human   175 ---------QIFPWMRKLH-----------ISHDMTGPDGKRARTAYTRYQTLELEKEFHFNRYL 219
                     .::||:...|           :......|  ||.|||::..|.|:||..|..|.|:
  Fly   266 APHLIRDSYPLYPWLLSRHGRIFPRFPGNFLFQPFRKP--KRVRTAFSPTQLLKLEHAFEGNHYV 328

Human   220 TRRRRIEIAHALCLSERQIKIWFQNRRMKWKK 251
            ....|.::|..|.|:|.|:|:||||||.|.|:
  Fly   329 VGAERKQLAQGLSLTETQVKVWFQNRRTKHKR 360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXB5	NP_002138.1	PRK07003	<67..>171	CDD:235906	32/185 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..173		27/176 (15%)
		Antp-type hexapeptide	176..181		2/4 (50%)
		Homeodomain	195..251	CDD:459649	26/55 (47%)
E5	NP_524825.1	Homeodomain	304..360	CDD:459649	26/55 (47%)