Protein Alignment HOXB5 and Ptx1

DIOPT Version :10

• Sequence 1: NP_002138.1
• Gene: HOXB5 / 3215
• HGNCID: 5116
• Length: 269
• Species: Homo sapiens
• Sequence 2: NP_001138130.2
• Gene: Ptx1 / 43664
• FlyBaseID: FBgn0020912
• Length: 610
• Species: Drosophila melanogaster
• Alignment Length: 278
• Identity: 78/278 - (28%)
• Similarity: 110/278 - (39%)
• Gaps: 74/278 - (26%)

Human    25 GSGSSLSGSYRDPAAMHTGSYGYNYNGMDLSVNRSSASSS----------HFGA----VGESSR- 74
            |.|||.||:      .|..|: ::.:....||:.|.|.||          |..|    ||..|:
  Fly   100 GGGSSTSGT------EHLHSH-HSLHDSSSSVSISPAISSLMPISSLSHLHHSAGQDLVGGYSQH 157

Human    75 ----AFP--APAQEP-----------RFRQAASSCSLSSPESLPCT--NGDSHGAKPSASSPSDQ 120
                ..|  .|..||           .||.:.||.: :...||..|  |.....:..|.|:.|..
  Fly   158 PHHTVVPPHTPKHEPLEKLRIWAETGDFRDSHSSMT-AVANSLDSTHLNNFQTSSTSSISNRSRD 221

Human   121 ATSASSSANFTEIDEASASSEPEEAASQLSSPSLARAQPEPMATSTAAPEGQTPQIFPWMRKLHI 185
            ....:.|.|.|.|...:.||...:               |||.||     |:.|:
  Fly   222 RKDGNRSVNETTIKTENISSSGHD---------------EPMTTS-----GEEPK---------- 256

Human   186 SHDMTGPDGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWK 250
             :|......:|.||.:|..|..|||..|..|||.....|.|||....|:|.::::||:|||.||:
  Fly   257 -NDKKNKRQRRQRTHFTSQQLQELEHTFSRNRYPDMSTREEIAMWTNLTEARVRVWFKNRRAKWR 320

Human   251 KDNKLKSMSLATAGSAFQ 268
            |..: .:|:.|.|.:.|:
  Fly   321 KRER-NAMNAAVAAADFK 337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXB5	NP_002138.1	PRK07003	<67..>171	CDD:235906	30/127 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..173		27/110 (25%)
		Antp-type hexapeptide	176..181		0/4 (0%)
		Homeodomain	195..251	CDD:459649	25/55 (45%)
Ptx1	NP_001138130.2	Homeodomain	265..321	CDD:459649	25/55 (45%)