DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HOXB5 and ro

DIOPT Version :9

Sequence 1:	NP_002138.1	Gene:	HOXB5 / 3215	HGNCID:	5116	Length:	269	Species:	Homo sapiens
Sequence 2:	NP_524521.1	Gene:	ro / 43234	FlyBaseID:	FBgn0003267	Length:	350	Species:	Drosophila melanogaster

Alignment Length:	202	Identity:	64/202 - (31%)
Similarity:	84/202 - (41%)	Gaps:	48/202 - (23%)

- Green bases have known domain annotations that are detailed below.

Human    98 ESLPCTNGD----SHGAKP------------SASSP----SDQATSASSSANFTEID-EASASSE 141
            |:....||:    :|..||            |.|||    ||:.||.   |.:...| ...|...
  Fly    53 ETRSSENGEIDVGTHAHKPPPCDTPYHSDGGSVSSPDISISDERTSL---AAYPAYDFYGHAKDY 114

Human   142 PEEAAS-------------QLSSPSLARAQPEPMATSTAAPEGQTPQIFP--WMRKLHISHDMTG 191
            |:..:.             ||....|:...|.|...:..|.....|..||  :....|.|...:.
  Fly   115 PQHPSQQHQQHHHHHHHPPQLVHQKLSYVSPPPAIAAGGAANPVLPHAFPAGFPSDPHFSAGFSA 179

Human   192 -------PDG--KRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRM 247
                   .:|  :|.||.::..|||.||.|||.|.|::|.||.|:|..|.|:|.||||||||||.
  Fly   180 FLARRRRKEGRQRRQRTTFSTEQTLRLEVEFHRNEYISRSRRFELAETLRLTETQIKIWFQNRRA 244

Human   248 KWKKDNK 254
            |.|:..|
  Fly   245 KDKRIEK 251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HOXB5	NP_002138.1	PRK07003	<67..>171	CDD:235906	24/106 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..173		24/108 (22%)
		Antp-type hexapeptide	176..181		2/6 (33%)
		Homeobox	198..251	CDD:395001	31/52 (60%)
ro	NP_524521.1	Homeobox	196..247	CDD:278475	30/50 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0489
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000007
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900