Protein Alignment HOXB5 and C15

DIOPT Version :10

• Sequence 1: NP_002138.1
• Gene: HOXB5 / 3215
• HGNCID: 5116
• Length: 269
• Species: Homo sapiens
• Sequence 2: NP_476873.2
• Gene: C15 / 42544
• FlyBaseID: FBgn0004863
• Length: 339
• Species: Drosophila melanogaster
• Alignment Length: 311
• Identity: 74/311 - (23%)
• Similarity: 109/311 - (35%)
• Gaps: 82/311 - (26%)

Human    33 SYRDPAAMHTGSYGYNYNGMDLSVNRSSASSSHFGA-----------VGESSRAFPAPAQEPRFR 86
            |:.:....|...:|......::.|:..|.|....|:           ..||........|..:.|
  Fly     3 SHEEDDHEHENEHGEEVEEQEIHVDVDSDSRMSCGSGSDVDMDGGSCYDESETPLSESLQSEQTR 67

Human    87 QAASSCSLSSPESLPCT----------------NGDSHGAKPSASSPSDQATS------------ 123
            .       ||.|:||.:                |.::|....|..|.|:...|
  Fly    68 S-------SSSENLPFSISRLLSKPFETSHHHHNNNNHLLSSSPGSSSNNNNSGEKGEEKELLQQ 125

Human   124 ---------ASSSANFTEIDEASASSEPEEAASQLSSPSLARAQPEPMATSTAAP---------- 169
                     |:|.||.|....|:..|.|....|......| |..|:....:.|.|
  Fly   126 EDHDLAYKLATSIANSTYGSAAALYSYPHLYPSAAGGHVL-RVPPQRTPLTWALPPLHHAALAHQ 189

Human   170 --EGQTPQIFPWMRKL-HISHDMTGPDGKRARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHAL 231
              :.:....||..|:: |...:.|.|..|:.||::||.|..||||.||..:||....|..:|..|
  Fly   190 AVKDRLAAAFPIARRIGHPYQNRTPPKRKKPRTSFTRIQVAELEKRFHKQKYLASAERAALARGL 254

Human   232 CLSERQIKIWFQNRRMKWKKD------------NKLK-SMSLATAGSAFQP 269
            .:::.|:|.||||||.||::.            |:|. |:........|.|
  Fly   255 KMTDAQVKTWFQNRRTKWRRQTAEEREAERQAANRLMLSLQAEAISKGFAP 305

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXB5	NP_002138.1	PRK07003	<67..>171	CDD:235906	30/163 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..173		27/144 (19%)
		Antp-type hexapeptide	176..181		2/4 (50%)
		Homeodomain	195..251	CDD:459649	27/55 (49%)
C15	NP_476873.2	COG5576	<196..315	CDD:227863	38/110 (35%)
		Homeodomain	218..274	CDD:459649	27/55 (49%)