Protein Alignment HOXB5 and CG18599

DIOPT Version :10

• Sequence 1: NP_002138.1
• Gene: HOXB5 / 3215
• HGNCID: 5116
• Length: 269
• Species: Homo sapiens
• Sequence 2: NP_650701.1
• Gene: CG18599 / 42191
• FlyBaseID: FBgn0038592
• Length: 475
• Species: Drosophila melanogaster
• Alignment Length: 301
• Identity: 71/301 - (23%)
• Similarity: 114/301 - (37%)
• Gaps: 72/301 - (23%)

Human    11 GRYPNGPDYQLLNYGSGSSLSGSYRDPAAMHTGSYGYNYNGMDLSVNRSSASSSHF----GAVGE 71
            |.:|:.|.....|..:.||.|.        ::.|:..|.|..:.....::.::||.    .|...
  Fly   106 GHHPHPPTPTTGNNNNNSSSSS--------NSSSHNSNSNHREQLAAAAATATSHAQLIEAAAAH 162

Human    72 SS----RAFPAPA------QEPRFRQAA---------------SSCSLSSPESLPCTNGDSHGAK 111
            ||    ::|...|      |...:..|.               :.|..|:|.:  ..|.:::|..
  Fly   163 SSLDVGKSFTIAAILGLQSQRKDYNNAINLSLHDNNNIIGDDNNKCYTSNPNN--NNNNNNNGGS 225

Human   112 PSASSPSDQATSASSSANFTEIDEASASSEPEEAASQLSSPSLARAQPEPMATSTAAPEGQTPQI 176
            .|.::      ::|.|.|....|..:.:........|...|..|.      ..:.||..|..|..
  Fly   226 NSGNN------NSSPSVNNFNCDSVAGNGRYLHGGHQHPHPHQAG------FAAVAAAVGAAPSA 278

Human   177 FPWMRKLH--------------------ISHDMTGPDGKRARTAYTRYQTLELEKEFHFNRYLTR 221
            ...:::||                    .||..:....||.||.:|..|...||.||...:|:..
  Fly   279 LQSLQQLHQQHHAQQQATLSFQREKLKSDSHKKSALKNKRVRTIFTPEQLECLEAEFERQQYMVG 343

Human   222 RRRIEIAHALCLSERQIKIWFQNRRMKWKKDN-KLKSMSLA 261
            ..|:.:||.|.|:|.|:|:||||||:||:|.: :|....||
  Fly   344 PERLYLAHTLKLTEAQVKVWFQNRRIKWRKHHLELTQQRLA 384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXB5	NP_002138.1	PRK07003	<67..>171	CDD:235906	22/128 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..173		19/116 (16%)
		Antp-type hexapeptide	176..181		0/4 (0%)
		Homeodomain	195..251	CDD:459649	27/55 (49%)
CG18599	NP_650701.1	Homeodomain	317..373	CDD:459649	27/55 (49%)