Protein Alignment HOXB5 and Dbx

DIOPT Version :10

• Sequence 1: NP_002138.1
• Gene: HOXB5 / 3215
• HGNCID: 5116
• Length: 269
• Species: Homo sapiens
• Sequence 2: NP_647677.2
• Gene: Dbx / 38254
• FlyBaseID: FBgn0261723
• Length: 741
• Species: Drosophila melanogaster
• Alignment Length: 318
• Identity: 72/318 - (22%)
• Similarity: 112/318 - (35%)
• Gaps: 114/318 - (35%)

Human    37 PAAMHTGSYGYNYNGMDLSVNRSSASSSHFGAVGESSRAFPAPA---------------QEPRFR 86
            |...|:..:.:::               |....|.....||.||               |..:.:
  Fly   217 PGHQHSHPHSHHH---------------HHHHPGAGHAHFPHPAFLTHQLPPHQHHQQQQHVQQQ 266

Human    87 QAASSC------SLSSPESLPCTNGDSHGAKPSASSPSDQATSASSS-----ANFTEIDEASAS- 139
            ...:||      |.|||.|....:.::|||..:..:.|....|...:     ||....:::|||
  Fly   267 HPGNSCQPQTASSSSSPGSTISDSDNNHGASTANGNGSGTGNSGQDARPHELANSNPDEDSSASR 331

Human   140 --SEPEEAASQL-------------------------SSPSLAR---AQPEPMATST-------- 166
              ::.::...||                         ..|.:|:   ::|.|....|
  Fly   332 RLTQDKQQQQQLLGAGGTGGGGGGGHGHGHPTPPPPPPPPVIAKPMPSRPTPFLPHTLNHPHLHS 396

Human   167 -----------------AAPEGQTPQIFPWMRKLHISHDMTGPD--GKRARTAYTRYQTLELEKE 212
                             ..|.||.   |||      :|...|..  |...|..::..|...|||.
  Fly   397 LLAHCRNPYMSVGAQVFPLPPGQG---FPW------AHSTRGKPRRGMMRRAVFSDSQRKGLEKR 452

Human   213 FHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWK--KDNKLKSMSLATAGSAFQ 268
            |...:|:::..|.::|..|.|.:.|:|||||||||||:  |:.:|    ||:.||..|
  Fly   453 FQQQKYISKPDRKKLAERLGLKDSQVKIWFQNRRMKWRNSKEREL----LASGGSRDQ 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXB5	NP_002138.1	PRK07003	<67..>171	CDD:235906	31/185 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..173		30/177 (17%)
		Antp-type hexapeptide	176..181		3/4 (75%)
		Homeodomain	195..251	CDD:459649	23/57 (40%)
Dbx	NP_647677.2	Homeodomain	437..491	CDD:459649	23/53 (43%)