Protein Alignment HOXB5 and en

DIOPT Version :10

• Sequence 1: NP_002138.1
• Gene: HOXB5 / 3215
• HGNCID: 5116
• Length: 269
• Species: Homo sapiens
• Sequence 2: NP_523700.2
• Gene: en / 36240
• FlyBaseID: FBgn0000577
• Length: 552
• Species: Drosophila melanogaster
• Alignment Length: 245
• Identity: 72/245 - (29%)
• Similarity: 107/245 - (43%)
• Gaps: 48/245 - (19%)

Human    52 MDLSVNRSSASSSHFGAVGESSRAFPAPA----QEPRFRQAASSCSLSSPESLPCTNGDSHGAKP 112
            |...::.::...|..|::.::......||    .:|....:|||.:...|.|...|...:.....
  Fly   282 MSSKMSDANPEKSALGSLCKAVSQIGQPAAPTMTQPPLSSSASSLASPPPASNASTISSTSSVAT 346

Human   113 SASSPSDQATSASSSANFTEIDEASASSEPEEAASQLSSPSLARAQPEPM--------------- 162
            |:||.|...:||:||.|.:......||.....|    |||     ||:|:
  Fly   347 SSSSSSSGCSSAASSLNSSPSSRLGASGSGVNA----SSP-----QPQPIPPPSAVSRDSGMESS 402

Human   163 -----ATSTAAPEGQTPQIFP-WMRKLHIS-HDMTGP-------------DGKRARTAYTRYQTL 207
                 .|.:...||...:::| |:.....| ...:||             |.||.|||::..|..
  Fly   403 DDTRSETGSTTTEGGKNEMWPAWVYCTRYSDRPSSGPRYRRPKQPKDKTNDEKRPRTAFSSEQLA 467

Human   208 ELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDNKLKS 257
            .|::||:.|||||.|||.:::..|.|:|.||||||||:|.|.||....|:
  Fly   468 RLKREFNENRYLTERRRQQLSSELGLNEAQIKIWFQNKRAKIKKSTGSKN 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXB5	NP_002138.1	PRK07003	<67..>171	CDD:235906	29/127 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..173		30/119 (25%)
		Antp-type hexapeptide	176..181		2/5 (40%)
		Homeodomain	195..251	CDD:459649	30/55 (55%)
en	NP_523700.2	Homeodomain	455..511	CDD:459649	30/55 (55%)
		Engrail_1_C_sig	512..542	CDD:431338	1/6 (17%)