Protein Alignment HOXB5 and H2.0

DIOPT Version :10

• Sequence 1: NP_002138.1
• Gene: HOXB5 / 3215
• HGNCID: 5116
• Length: 269
• Species: Homo sapiens
• Sequence 2: NP_523488.2
• Gene: H2.0 / 33841
• FlyBaseID: FBgn0001170
• Length: 418
• Species: Drosophila melanogaster
• Alignment Length: 282
• Identity: 63/282 - (22%)
• Similarity: 99/282 - (35%)
• Gaps: 97/282 - (34%)

Human    37 PAAMHTGSYGYNYNGMDLSVNRSSASSSHFGAVGESSRAFPAPAQE------PRFRQAASSCSLS 95
            |....|.|:.|.:.|:|                    :.||.|..:      |...:||...:.:
  Fly   132 PTFTPTSSHTYPFVGLD--------------------KLFPGPYMDYKSVLRPTPIRAAEHAAPT 176

Human    96 SPESLPCTNG-----------------DSHGAK---PSASSPSDQATSAS---------SSANFT 131
            .|..  .||.                 ..|..|   .....|...:|:||         :|...|
  Fly   177 YPTL--ATNALLRFHQHQKQQHQQHHHHQHHPKHLHQQHKPPPHNSTTASALLAPLHSLTSLQLT 239

Human   132 EIDEASASSEPEEAASQLSSPSLARAQPEPMATSTA--------APEGQTPQIFPWMRKLHISHD 188
            :..:......|::..      .:|...|...|.:|:        ...||             .:.
  Fly   240 QQQQRFLGKTPQQLL------DIAPTSPAAAAAATSQNGAHGHGGGNGQ-------------GNA 285

Human   189 MTGPDGKR----ARTAYTRYQTLELEKEFHFNRYLTRRRRIEIAHALCLSERQIKIWFQNRRMKW 249
            ..|.:|||    :|..::..|...||.:|...:|:|:..|.::|..|.|::.|:|:|||||||||
  Fly   286 SAGSNGKRKRSWSRAVFSNLQRKGLEIQFQQQKYITKPDRRKLAARLNLTDAQVKVWFQNRRMKW 350

Human   250 K--KDNKLKSMSLATAGSAFQP 269
            :  ::| |||      |...||
  Fly   351 RHTREN-LKS------GQEKQP 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXB5	NP_002138.1	PRK07003	<67..>171	CDD:235906	22/146 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..173		22/138 (16%)
		Antp-type hexapeptide	176..181		0/4 (0%)
		Homeodomain	195..251	CDD:459649	24/61 (39%)
H2.0	NP_523488.2	Homeodomain	292..352	CDD:459649	24/59 (41%)