Protein Alignment HOXB5 and B-H1

DIOPT Version :10

• Sequence 1: NP_002138.1
• Gene: HOXB5 / 3215
• HGNCID: 5116
• Length: 269
• Species: Homo sapiens
• Sequence 2: NP_523387.1
• Gene: B-H1 / 32724
• FlyBaseID: FBgn0011758
• Length: 544
• Species: Drosophila melanogaster
• Alignment Length: 314
• Identity: 77/314 - (24%)
• Similarity: 126/314 - (40%)
• Gaps: 60/314 - (19%)

Human     2 SSYFVNSF------SGRYPNGPDYQLLNYGSGSSLSGSYRDPAAMHTGSYGYNYNGMDLSVNRSS 60
            |.:.:|..      :..|.....:|.|::.:.::.|||....:..|:     |.|.   ::|..:
  Fly    75 SRFMINDILAGSAAAAFYKQQQHHQQLHHHNNNNNSGSSGGSSPAHS-----NNNN---NINGDN 131

Human    61 ASSSHFGAVGESSRAFPAPAQEPRFRQAASSCSLSSPES----LPCTNGDS--HGAKPSASSPSD 119
            ..:|:...||....|...|...|.........:|..|..    .|.|.|.:  :.|:.:|:....
  Fly   132 CEASNVAGVGVLPSALHHPQPHPPTHPHTHPHALMHPHGKLGHFPPTAGGNGLNVAQYAAAMQQH 196

Human   120 QATSASSSANFTEIDEASASSEPEEAASQLSSP-------SLARAQP------------------ 159
            .|.:|:::|.......|:|::....||...:.|       .:..|.|
  Fly   197 YAAAAAAAAARNNAAAAAAAAAAAAAAGVAAPPVDGGVDGGVGLAPPAGGDLDDSSDYHEENEDC 261

Human   160 ------EPMATSTAAPEGQTPQIFPWMRKLHISHDMTGPDGK--RARTAYTRYQTLELEKEFHFN 216
                  :....|....:.....:     |...:.||:|...|  :||||:|.:|...|||.|...
  Fly   262 DSGNMDDHSVCSNGGKDDDGNSV-----KSGSTSDMSGLSKKQRKARTAFTDHQLQTLEKSFERQ 321

Human   217 RYLTRRRRIEIAHALCLSERQIKIWFQNRRMKWKKDNKLKSMSLATAG--SAFQ 268
            :||:.:.|.|:||.|.||:.|:|.|:||||.|||:...:....||.||  :|||
  Fly   322 KYLSVQERQELAHKLDLSDCQVKTWYQNRRTKWKRQTAVGLELLAEAGNFAAFQ 375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXB5	NP_002138.1	PRK07003	<67..>171	CDD:235906	23/140 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	77..173		20/132 (15%)
		Antp-type hexapeptide	176..181		0/4 (0%)
		Homeodomain	195..251	CDD:459649	29/57 (51%)
B-H1	NP_523387.1	Homeodomain	300..356	CDD:459649	28/55 (51%)