DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10353 and IST2

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	NP_009643.2	Gene:	IST2 / 852382	SGDID:	S000000290	Length:	946	Species:	Saccharomyces cerevisiae

Alignment Length:	812	Identity:	147/812 - (18%)
Similarity:	270/812 - (33%)	Gaps:	297/812 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 EPRIHLEFSRNYLELYDTEHPNFLDASTRYSIINF----------ILQRQRFVEGEETADNLGIE 353
            |..:::||.|  |.::....|.. |..|.|:.|..          .||...|:|.
Yeast    24 EKSLNVEFKR--LNIHSIIEPGH-DLQTSYAFIRIHQDNAKPLFSFLQNLDFIES---------- 75

  Fly   354 KLVQDGVYTCAYTLHD---KDDRDRLLKEWANISKWKNLQPLDQIKDY------FGAKVALYFAW 409
                      ....||   .||..:|:    :|||.|.|:...|.:.|      ...|.:||||:
Yeast    76 ----------IIPYHDTELSDDLHKLI----SISKSKILEAPKQYELYNLSNLTNNPKQSLYFAF 126

  Fly   410 LGFYTQMLIPISVFGV-LCFLYGFITWNSDPISRDICDDNGTIMCPQCDRSCDYWRLNETCTSSK 473
            |..|.:.|||.|.||: :.||                                          |.
Yeast   127 LQNYIKWLIPFSFFGLSIRFL------------------------------------------SN 149

  Fly   474 FNYLIDNNMTVVFAFSMAIWAVVYLEFWKRYSAGLVHRWGLTGFTHHVEHPRPQYLARISRTKKL 538
            |.|.. |:...:||.   :|.:.:..||       ::::            .|.:..|:|:....
Yeast   150 FTYEF-NSTYSLFAI---LWTLSFTAFW-------LYKY------------EPFWSDRLSKYSSF 191

  Fly   539 AGKAYEQDHTGKRTILDPDVPFWSFKFLPNFTSYSIMVLFICISVIAIAGIIIYRMAQRASHSIL 603
            :...:.||....:......:......|:|....:..::|...:...|:. |.|.::......|||
Yeast   192 STIEFLQDKQKAQKKASSVIMLKKCCFIPVALLFGAILLSFQLYCFALE-IFIKQIYNGPMISIL 255

  Fly   604 GSENSMTFKVMILPMTAGIIDLIVISLLDMVYSNLAVK-LTNYEYCRTQTEYDESLTIKNYVFQF 667
                |....::|...|         .:|.::|:...|: :|.:|...:.....:|...||:|..|
Yeast   256 ----SFLPTILICTFT---------PVLTVIYNKYFVEPMTKWENHSSVVNAKKSKEAKNFVIIF 307

  Fly   668 VNYYSSLFYIAFL-----------------------------KGKFVGYPAKY----------NR 693
            ::.|..|....||                             ...|:....:|          |:
Yeast   308 LSSYVPLLITLFLYLPMGHLLTAEIRTKVFNAFSILARLPTHDSDFIIDTKRYEDQFFYFIVINQ 372

  Fly   694 VLGFRQEECNPGGCLMELCMQLVIIMAGKQAVNAIVEMLIPYLMRTFKEL-------SYRHGW-- 749
            ::.|..|...|.           ::...:|.:|.    ..|..::...|:       |....|
Yeast   373 LIQFSMENFVPS-----------LVSIAQQKING----PNPNFVKAESEIGKAQLSSSDMKIWSK 422

  Fly   750 YKSHQDQRLVPYN-QFTEDYNLLPAENNSLYVEYLEMVVQFGFITLFSLAFPLAPLLALLNNVIE 813
            .||:|..   |:. .|..|.|            :.::::|||::.:||..:||||.:.|:.|:|.
Yeast   423 VKSYQTD---PWGATFDLDAN------------FKKLLLQFGYLVMFSTIWPLAPFICLIVNLIV 472

  Fly   814 VRLDAIKMLRFLR----------RPVGM---RARDIGVWHSIMTVVTRI-AVASSAMIIAFSTNL 864
            .::|..|.:.:.:          :|..:   :...:|:|:|::.:.:.: .|.::.:...:.:..
Yeast   473 YQVDLRKAVLYSKPEYFPFPIYDKPSSVSNTQKLTVGLWNSVLVMFSILGCVITATLTYMYQSCN 537

  Fly   865 IPKIVYAAS--------MGDPELNNYLNFTL-AVFNTKDFQVQPLLGGSQHVNETVCRYTEFRNS 920
            ||.:....|        :.:|..::::|..| |||             .:||:..
Yeast   538 IPGVGAHTSIHTNKAWYLANPINHSWINIVLYAVF-------------IEHVSVA---------- 579

  Fly   921 PEDPHPYKRPMIYWKILTGRLAFIVIYQNIITMLQGILRWAVPDVSGRLLKRIKRENFLLREHII 985
                                         |..:...||:.:..||:          |.::.:|::
Yeast   580 -----------------------------IFFLFSSILKSSHDDVA----------NGIVPKHVV 605

  Fly   986 EYE---KQHAM-KLVQTELNGQQKSEGELRQR 1013
            ..:   ||... |:...|.|  ..:|.||.||
Yeast   606 NVQNPPKQEVFEKIPSPEFN--SNNEKELVQR 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	24/105 (23%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	110/661 (17%)
IST2	NP_009643.2	Anoctamin	122..588	CDD:398306	104/626 (17%)
IST2	NP_009643.2	PRK13335	779..>880	CDD:139494
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I2829
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.940