Protein Alignment CG10353 and ANO3

DIOPT Version :10

• Sequence 1: NP_727578.3
• Gene: CG10353 / 32148
• FlyBaseID: FBgn0030349
• Length: 1029
• Species: Drosophila melanogaster
• Sequence 2: NP_001300655.1
• Gene: ANO3 / 63982
• HGNCID: 14004
• Length: 1042
• Species: Homo sapiens
• Alignment Length: 913
• Identity: 317/913 - (34%)
• Similarity: 480/913 - (52%)
• Gaps: 138/913 - (15%)

  Fly   164 KDKKLPITYSQWKSRTYRR-----------FDDGKRSVDFVLAYNGETQLEEHRRKCEIFEANLQ 217
            |||      |::|::..:.           |.|||:.:|::|.|. :|.::..:|  ..||.||:
Human   194 KDK------SEFKTKLSKNDMNYIASSGPLFKDGKKRIDYILVYR-KTNIQYDKR--NTFEKNLR 249

  Fly   218 REGLQLEHNKV---QRVHFIKIHAPAEVLYRYAEILKIKVPLKPIPGQDQIFAESAHEFKTCFSR 279
            .|||.||....   ..:.|||||.|.:.|.:|||.|.|::|.:.........::|....:|.|.|
Human   250 AEGLMLEKEPAIASPDIMFIKIHIPWDTLCKYAERLNIRMPFRKKCYYTDGRSKSMGRMQTYFRR 314

  Fly   280 MCKSLFSS-VQLNTALFPERE-----------PRIHLEFSRNYLELYDTEHPNFLDASTRYSIIN 332
            :...:..: :.|:.:.||:.|           .|||.....|    .||    |...:||..|:.
Human   315 IKNWMAQNPMVLDKSAFPDLEESDCYTGPFSRARIHHFIINN----KDT----FFSNATRSRIVY 371

  Fly   333 FILQRQRFVEGEETADNLGIEKLVQDGVYTCAYTLHD--------------KDDRDRLLKEWANI 383
            .:|:|.::..|   ...:||.||:.:|.|..|:..|:              :::|..|.:.||..
Human   372 HMLERTKYENG---ISKVGIRKLINNGSYIAAFPPHEGAYKSSQPIKTHGPQNNRHLLYERWARW 433

  Fly   384 SKWKNLQPLDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGVLCFLYGFITWNSDPISRDICDDN 448
            ..|...||||.|:.|||.|:.|||||||:||.||||.::.|:..|.||..|.|:..:|::||...
Human   434 GMWYKHQPLDLIRLYFGEKIGLYFAWLGWYTGMLIPAAIVGLCVFFYGLFTMNNSQVSQEICKAT 498

  Fly   449 GTIMCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSMAIWAVVYLEFWKRYSAGLVHRWG 513
            ...|||.||::|...|||::|..:|..||.||..||.||..|||||.|:||||||..:.|.:.|.
Human   499 EVFMCPLCDKNCSLQRLNDSCIYAKVTYLFDNGGTVFFAIFMAIWATVFLEFWKRRRSILTYTWD 563

  Fly   514 LTGFTHHVEHPRPQYLARISRTKKLAGKAYEQD----HTGKRTILDPDVPFWSFKFLPNFTSYSI 574
            |..:....|..|||:.|          |.|:.:    .|||.   :|..|. |.|......|.|.
Human   564 LIEWEEEEETLRPQFEA----------KYYKMEIVNPITGKP---EPHQPS-SDKVTRLLVSVSG 614

  Fly   575 MVLFICISVIAIAGIIIYRMAQRASHSILGSENSMTFKVMILPM--------TAGIIDLIVISLL 631
            :...|.:.:.|:.|:::||        ::..|...:||...:..        .|..|:.|:|.||
Human   615 IFFMISLVITAVFGVVVYR--------LVVMEQFASFKWNFIKQYWQFATSAAAVCINFIIIMLL 671

  Fly   632 DMVYSNLAVKLTNYEYCRTQTEYDESLTIKNYVFQFVNYYSSLFYIAFLKGKFVGYPAKYNRVLG 696
            ::.|..:|..|||.||.||::|::.|..:|.::|||||..||:|||||..|:|||:|.|||::..
Human   672 NLAYEKIAYLLTNLEYPRTESEWENSFALKMFLFQFVNLNSSIFYIAFFLGRFVGHPGKYNKLFD 736

  Fly   697 -FRQEECNPGGCLMELCMQLVIIMAGKQAVNAIVEMLIPYLMRTFKELSYRHGWYKSHQDQR--- 757
             :|.|||:|.|||::||:|:.:||..||..|..:|:..|.:          ..|:..|:.:|
Human   737 RWRLEECHPSGCLIDLCLQMGVIMFLKQIWNNFMELGYPLI----------QNWWSRHKIKRGIH 791

  Fly   758 --LVPYNQFTEDYNLLPAENNSLYVEYLEMVVQFGFITLFSLAFPLAPLLALLNNVIEVRLDAIK 820
              .:|  |:..|:||.|...:.|..||||||:||||.|:|..|||||||||||||:||:||||.|
Human   792 DASIP--QWENDWNLQPMNLHGLMDEYLEMVLQFGFTTIFVAAFPLAPLLALLNNIIEIRLDAYK 854

  Fly   821 MLRFLRRPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAFSTNLIPKIVYAASMG------DPE- 878
            .:...|||:..||.|||:|..|:..:..:||.::|.:||.:::.||:.||....|      :|.
Human   855 FVTQWRRPLPARATDIGIWLGILEGIGILAVITNAFVIAITSDYIPRFVYEYKYGPCANHVEPSE 919

  Fly   879 --LNNYLNFTLAVFNTKDFQVQPLLGGSQHVNETVCRYTEFRNSPEDPHPYKRPMIYWKILTGRL 941
              |..|:|.:|:.|:..:..    :|.|.:     |||.::|..|....||:..:.||.||..||
Human   920 NCLKGYVNNSLSFFDLSELG----MGKSGY-----CRYRDYRGPPWSSKPYEFTLQYWHILAARL 975

  Fly   942 AFIVIYQNIITMLQGILRWAVPDVSGRLLKRIKRENFLLREHIIEYEKQHAMKLVQTELNGQQKS 1006
            |||:::::::..::..:.:.:|||...|..||:||.:|::|.:.|.|.:|        |..|::.
Human   976 AFIIVFEHLVFGIKSFIAYLIPDVPKGLHDRIRREKYLVQEMMYEAELEH--------LQQQRRK 1032

  Fly  1007 EGE 1009
            .|:
Human  1033 SGQ 1035

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_727578.3	Anoct_dimer	183..392	CDD:465044	66/237 (28%)
		Anoctamin	395..976	CDD:461349	233/607 (38%)
ANO3	NP_001300655.1	Anoct_dimer	218..442	CDD:465044	66/237 (28%)
		Anoctamin	445..1010	CDD:461349	233/607 (38%)