DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10353 and ANO8

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	NP_066010.1	Gene:	ANO8 / 57719	HGNCID:	29329	Length:	1232	Species:	Homo sapiens

Alignment Length:	1128	Identity:	240/1128 - (21%)
Similarity:	380/1128 - (33%)	Gaps:	416/1128 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 DAAIAAQMIALQNGRNHLPTGIGVTGDGGQGGGDDEVSRRLLRTSSNISNKDKKLPITYSQWKSR 178
            :||..|...:|:..|...|...|.......|..|....:|||:....:        :::..|...
Human     3 EAASGAGGTSLEGERGKRPPPEGEPAAPASGVLDKLFGKRLLQAGRYL--------VSHKAWMKT 59

  Fly   179 TYRRFDDGKRSVDFVLAYNGETQLEEHRRKCEIFEANLQREGL-----QLEHNKVQRVHFIKIHA 238
            .      ...:.|.::.:...|  ::|..   ::..|..|.|:     |:.|::..|.:...:.|
Human    60 V------PTENCDVLMTFPDTT--DDHTL---LWLLNHIRVGIPELIVQVRHHRHTRAYAFFVTA 113

  Fly   239 PAEVLYRYAEILKIKVPLKPIPGQDQIFAESAHEFKTCFSRMCKS--LFSSVQLNTALFPEREPR 301
            ..|.|.|.|:.|.::..:|      ..|......|.      |:.  ::.:|:.....|..:|
Human   114 TYESLLRGADELGLRKAVK------AEFGGGTRGFS------CEEDFIYENVESELRFFTSQE-- 164

  Fly   302 IHLEFSRNYLELYDTEHPNFLDASTRYSIINFILQRQRFVEGEE------TADNLGIEKLVQDGV 360
                                     |.|||.|.||..|..:||.      ..|...|.:|...|:
Human   165 -------------------------RQSIIRFWLQNLRAKQGEALHNVRFLEDQPIIPELAARGI 204

  Fly   361 YTCAYTLHDKDDRDRLLKEWANISKWKNLQPLDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGV 425
            ....:.:|::...:||:|.|.. :..:| ||||.|.||||.|:|:|||||||||..::..:|||.
Human   205 IQQVFPVHEQRILNRLMKSWVQ-AVCEN-QPLDDICDYFGVKIAMYFAWLGFYTSAMVYPAVFGS 267

  Fly   426 LCFLYGFITWNSDPISRDICDDNGTIMCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSM 490
            :  ||.|.  .:|..|||:              ||                       ||||...
Human   268 V--LYTFT--EADQTSRDV--------------SC-----------------------VVFALFN 291

  Fly   491 AIWAVVYLEFWKRYSAGLVHRWG-LTGFTHHVEHPRPQY--LARISRTKKLAGKAYEQDHTGKRT 552
            .||:.::||.|||..|.|.::|| |......||.||||:  :.|||...:.....|
Human   292 VIWSTLFLEEWKRRGAELAYKWGTLDSPGEAVEEPRPQFRGVRRISPITRAEEFYY--------- 347

  Fly   553 ILDPDVPFWS---FKFLPNFTSYSIMVLFICISVIAIAGIIIYRMAQRASHSILGSENSMTFKVM 614
                  |.|.   |:.|     .|:.:...|:..:.:..:..:::.:            :...|.
Human   348 ------PPWKRLLFQLL-----VSLPLCLACLVCVFLLMLGCFQLQE------------LVLSVK 389

  Fly   615 ILPMTAGIIDLIVISLLDMV----YSNLAVKLTNYEYCRTQTEYDESLTIKNYVFQFVNYYSSLF 675
            .||..|..:..::::||..|    |..||:.|.:.|..|.::.|::.|.||..:|||||.|.|||
Human   390 GLPRLARFLPKVMLALLVSVSAEGYKKLAIWLNDMENYRLESAYEKHLIIKVVLFQFVNSYLSLF 454

  Fly   676 YIAF-LKG---------------------KFVGYPAKYNRV----LGFRQ--------------- 699
            ||.| ||.                     :.|..|..|.|:    ||.|.
Human   455 YIGFYLKDMERLKEMLATLLITRQFLQNVREVLQPHLYRRLGRGELGLRAVWELARALLGLLSLR 519

  Fly   700 -----------------------EECNPGGC---------------------------------- 707
                                   ..|..|||
Human   520 RPAPRRLEPQADEGGGGGSGGGGRRCLSGGCGAPEEEEEAALVERRRAGEGGEEGDGPPGGKEED 584

  Fly   708 ----------------------LMELCMQLVIIM-----AGKQAVNAIVEMLIPYLMRTFKELSY 745
                                  |::..::|..:.     ||::......|.|:.....|..|...
Human   585 EDDEEEEDEEEEEDEEEGEEGGLLDCGLRLKKVSFAERGAGRRRPGPSPEALLEEGSPTMVEKGL 649

  Fly   746 RHGWYK---------------------------------------------SHQDQRLVPYNQFT 765
            ..|.:.                                             |:.|.......|..
Human   650 EPGVFTLAEEDDEAEGAPGSPEREPPAILFRRAGGEGRDQGPDGGPDPEPGSNSDSTRRQRRQNR 714

  Fly   766 EDYNLLPAENNS-----------------LYVEYLEMVVQFGFITLFSLAFPLAPLLALLNNVIE 813
            ..:...|.|.:|                 .:.:|.||.||||::.|||.|||||.|.||:||:||
Human   715 SSWIDPPEEEHSPQLTQAELESCMKKYEDTFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIE 779

  Fly   814 VRLDAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAFSTNLIPKIVYAASMGDPE 878
            :|.||.|:...|:||.|.|...||.|..:|..:..:|:..:..:|             ...|
Human   780 IRSDAFKLCTGLQRPFGQRVESIGQWQKVMEAMGVLAIVVNCYLI-------------GQCG--- 828

  Fly   879 LNNYLNFTLAVFNTKDFQVQPLLGGSQHVNETVCRYTEFRNSPEDPHPYKRPMIYWKILTGRLAF 943
                             |:|.|.                        |:..|       ...:..
Human   829 -----------------QLQRLF------------------------PWLSP-------EAAIVS 845

  Fly   944 IVIYQNIITMLQGILRWAVPDVSGRLLKRIKRENFLLREHIIEYEKQHAMKLVQTELNGQQKSEG 1008
            :|:.::...:|:.::..|:||:.|.:.:.:.:..:..||....:|:|...:..|.:   :::.|.
Human   846 VVVLEHFALLLKYLIHVAIPDIPGWVAEEMAKLEYQRREAFKRHERQAQHRYQQQQ---RRRREE 907

  Fly  1009 ELRQRNNETVIR------NRDEA 1025
            |.|||:.|...|      .|:||
Human   908 EERQRHAEHHARREHDSGGREEA 930

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	43/221 (19%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	166/778 (21%)
ANO8	NP_066010.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		7/28 (25%)
		Anoctamin	237..877	CDD:398306	166/776 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..650		12/125 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	681..728		6/46 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	888..970		13/46 (28%)
		PHA03307	<940..>1120	CDD:223039
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	997..1152
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1174..1232
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950