DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10353 and ANO2

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	NP_001265525.1	Gene:	ANO2 / 57101	HGNCID:	1183	Length:	1003	Species:	Homo sapiens

Alignment Length:	1027	Identity:	371/1027 - (36%)
Similarity:	521/1027 - (50%)	Gaps:	177/1027 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 GGGGGDHTDAAI---AAQMIALQNGRNHLPTGIGVTGDGGQGGGDDEVSRRLLRTSSNISN-KDK 166
            ||.|..|....:   ..:...||.|.|.         |.||..|.:..     |:||.|:| .|.
Human    27 GGQGPKHGQQCLKMPGPRAPGLQGGSNR---------DPGQPCGGEST-----RSSSVINNYLDA 77

  Fly   167 KLPITYSQWKSRTYRRFDDGKRSVDFVLAY----------------------NGET--------- 200
            ..|::.....||.:  |.|.:|.||:||||                      ||||
Human    78 NEPVSLEARLSRMH--FHDSQRKVDYVLAYHYRKRGVHLAQGFPGHSLAIVSNGETGKEPHAGGP 140

  Fly   201 ---------QLEEHRR-KCEIFEANLQREGLQLE---HNKVQRVHFIKIHAPAEVLYRYAEILKI 252
                     .|||.|: :.|.||.||...||:||   .||.|...|::||||.:||.|.||.|||
Human   141 GDIELGPLDALEEERKEQREEFEHNLMEAGLELEKDLENKSQGSIFVRIHAPWQVLAREAEFLKI 205

  Fly   253 KVPLKPIPGQDQIFAESAHEFKT------CFSRMCKSLFSSVQLNTALFPE----REPRIHLEFS 307
            |||.|          :..:|.|.      .||...:.|.|.:|...   ||    :...:...||
Human   206 KVPTK----------KEMYEIKAGGSIAKKFSAALQKLSSHLQPRV---PEHSNNKMKNLSYPFS 257

  Fly   308 RNYLELYD-TEHPNFLDASTRYSIINFILQRQRFVEGEETADNLGIEKLVQDGVYTCAYTLH--- 368
            |..:.||: .|...|.|.:||..|::.||:|........|   :||..|:.:.:|..||.||
Human   258 REKMYLYNIQEKDTFFDNATRSRIVHEILKRTACSRANNT---MGINSLIANNIYEAAYPLHDGE 319

  Fly   369 ------DKDDRDRLLKEWANISKWKNLQPLDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGVLC 427
                  |.:||..|.:|||....:...||:|.|:.|||.|:.|||||||.||..|||.||.||:.
Human   320 YDSPEDDMNDRKLLYQEWARYGVFYKFQPIDLIRKYFGEKIGLYFAWLGLYTSFLIPSSVIGVIV 384

  Fly   428 FLYGFITWNSDPISRDICD-DNGTIMCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSMA 491
            ||||..|...|..||::|| .|...|||.||:|||||.|:..|.:::.::|.||..||.|:..||
Human   385 FLYGCATIEEDIPSREMCDQQNAFTMCPLCDKSCDYWNLSSACGTAQASHLFDNPATVFFSIFMA 449

  Fly   492 IWAVVYLEFWKRYSAGLVHRWGLTGFTHH----VEHPRPQYLARI----------SRTKKLAGKA 542
            :||.::||.|||....|.:.|.|||....    .||.||:|..::          |..:||....
Human   450 LWATMFLENWKRLQMRLGYFWDLTGIEEEEERAQEHSRPEYETKVREKMLKESNQSAVQKLETNT 514

  Fly   543 YE---QDHTGKRTILDPDVPFWSFKF---LPNFTSYSIMVLF-ICISVIAIAGIIIYRMAQRASH 600
            .|   :|...|.|        |..:|   |.||.|    :|| |.::...:.|:|:||:...|:.
Human   515 TECGDEDDEDKLT--------WKDRFPGYLMNFAS----ILFMIALTFSIVFGVIVYRITTAAAL 567

  Fly   601 SILGSENSMTFKVMILPMTAGIIDLIVISLLDMVYSNLAVKLTNYEYCRTQTEYDESLTIKNYVF 665
            | |........:|.: ..||.||:|:||.:||.:|..:|..||..|..:|:..::|.|.:|.::.
Human   568 S-LNKATRSNVRVTV-TATAVIINLVVILILDEIYGAVAKWLTKIEVPKTEQTFEERLILKAFLL 630

  Fly   666 QFVNYYSSLFYIAFLKGKFVGYPAKYNRVL-GFRQEECNPGGCLMELCMQLVIIMAGKQAV-NAI 728
            :|||.||.:||:||.||:|||.|..|..|. |:|.|||.|||||||||:||.|||.|||.: |.|
Human   631 KFVNAYSPIFYVAFFKGRFVGRPGSYVYVFDGYRMEECAPGGCLMELCIQLSIIMLGKQLIQNNI 695

  Fly   729 VEMLIPYLMRTFKEL------SYRHGWYKSHQDQRLVPYNQFTEDYNLLPAENNSLYVEYLEMVV 787
            .|:.:|.|.:.|::|      ......:..|.:       |:..||:|.|  ...|..||:||::
Human   696 FEIGVPKLKKLFRKLKDETEAGETDSAHSKHPE-------QWDLDYSLEP--YTGLTPEYMEMII 751

  Fly   788 QFGFITLFSLAFPLAPLLALLNNVIEVRLDAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIAVA 852
            ||||:|||..:|||||:.|||||||||||||.|.:..||||..:|.:|||:|..|::.:.:.:|.
Human   752 QFGFVTLFVASFPLAPVFALLNNVIEVRLDAKKFVTELRRPDAVRTKDIGIWFDILSGIGKFSVI 816

  Fly   853 SSAMIIAFSTNLIPKIVYAASMG-DPELNNYLNFTLAVFNTKDFQVQPLLGGSQHVNE------T 910
            |:|.:||.:::.||::||..|.. :..|:.::|.||:.||     |..|..|:|..|.      .
Human   817 SNAFVIAITSDFIPRLVYQYSYSHNGTLHGFVNHTLSFFN-----VSQLKEGTQPENSQFDQEVQ 876

  Fly   911 VCRYTEFRNSPEDPHPYKRPMIYWKILTGRLAFIVIYQNIITMLQGILRWAVPDVSGRLLKRIKR 975
            .||:.::|..|..|:||:....||.||:.||||::|:||::..|..::.|.:||:...:..:||:
Human   877 FCRFKDYREPPWAPNPYEFSKQYWFILSARLAFVIIFQNLVMFLSVLVDWMIPDIPTDISDQIKK 941

  Fly   976 ENFLLREHIIEYEKQHAMKLVQTELNGQQKSEGELRQRNNETVIRNRDEATS 1027
            |..||.:..:: |:...:||:         .|..||......  |:|..|.|
Human   942 EKSLLVDFFLK-EEHEKLKLM---------DEPALRSPGGGD--RSRSRAAS 981

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	86/272 (32%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	249/618 (40%)
ANO2	NP_001265525.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..68		13/54 (24%)
		Anoct_dimer	91..349	CDD:292796	86/275 (31%)
		Anoctamin	352..943	CDD:282414	249/618 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	961..1003		7/32 (22%)
		DLG4 binding (PDZ)	1001..1003
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H23221
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.820