Protein Alignment CG10353 and ano2b

DIOPT Version :10

• Sequence 1: NP_727578.3
• Gene: CG10353 / 32148
• FlyBaseID: FBgn0030349
• Length: 1029
• Species: Drosophila melanogaster
• Sequence 2: NP_001314787.1
• Gene: ano2b / 566373
• ZFINID: ZDB-GENE-060503-62
• Length: 1065
• Species: Danio rerio
• Alignment Length: 1048
• Identity: 336/1048 - (32%)
• Similarity: 520/1048 - (49%)
• Gaps: 221/1048 - (21%)

  Fly   147 DDEV---------SRRLLRTSSNISNKDKKLPITYSQWKSRTYRRFDDGKRSVDFVLAY------ 196
            ||.|         |..:|:||.|..:....:.......:.|.|  |.||:|.||:||.:
Zfish    52 DDSVDFIEESLHHSDNMLQTSGNKIHVANNMMDMDQDPRKRLY--FADGRRKVDYVLVFHYRKRS 114

  Fly   197 ---------------NGETQL--EE------HRRKCEI--------------------FEANLQR 218
                           ||...|  ||      .....|:                    ||.:|:.
Zfish   115 SIRGSPSQHRLSIISNGSYHLGVEEKDPEGGKEEPAEVVVDVGPPDPAEGEKIMIREEFEGSLKD 179

  Fly   219 EGLQLEHNKVQRVH---FIKIHAPAEVLYRYAEILKIKV-------------------------- 254
            .||::|.:|..:.|   ||::|||.:||.|.||.|||||
Zfish   180 AGLEIERDKENKAHGHAFIRLHAPWQVLSREAEFLKIKVQTKKSYELREEKGLAATMNEVWRKLN 244

  Fly   255 -PLKP-IPGQDQIFAESAHEFKTCFSRMCKSLFSSVQLNTALFPEREPRIHLEFSRNYLELYDTE 317
             |.:| :|.|:|      ...:|.|...|                        |||:.|.||:.:
Zfish   245 QPFQPKVPHQEQ------ENSRTKFLTHC------------------------FSRDKLHLYNIQ 279

  Fly   318 HPN-FLDASTRYSIINFILQRQRFVEGEETADNLGIEKLVQDGVYTCAYTLHD-----------K 370
            ..: |.|.:||..|:..||:|....   .|...:||..|:.:|||..|:.|||           |
Zfish   280 SKDTFFDNATRSRIVYEILRRTACT---RTCQTMGITTLIANGVYDSAFPLHDGDFHSSGQAEGK 341

  Fly   371 DDRDRLLKEWANISKWKNLQPLDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGVLCFLYGFITW 435
            ::|..|..|||....:...||:|.|:.|||.|:.|||||||.|||:|||.||.|::.|.||:.|.
Zfish   342 NERQLLHDEWARYGAFYKYQPIDLIRKYFGEKIGLYFAWLGVYTQLLIPASVVGIIVFFYGWATV 406

  Fly   436 NSDPISRDICDDNGTI-MCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSMAIWAVVYLE 499
            .::..|:::||:.... |||.|||.||||:|:..|.:::.::|.||..||.||..|::||.::||
Zfish   407 ETNVPSQEMCDETQNFTMCPLCDRVCDYWQLSTACGTARASHLFDNPATVFFAIFMSLWAAMFLE 471

  Fly   500 FWKRYSAGLVHRWGLTGFTHHVEHPRPQY----LARISRTKKLAGKAYEQ----DHTGKRTILDP 556
            .|||....|.:.|.|||.....|||||:|    |.:..|.||......|.    |.:|:   |..
Zfish   472 HWKRRQISLNYSWDLTGMEEEEEHPRPKYETILLQKRQRKKKNKKNKNEPERVVDESGE---LGK 533

  Fly   557 DVPFWSFKF--------------------LPNFTSYSIMVLFIC-ISVIAIAGIIIYRMAQRASH 600
            |.  |..:.                    ||.:......:||:. ::..|:..:||||:...|..
Zfish   534 DK--WRQRLLSAMAAGNPTGHEKLTWRDRLPGYLINISSILFMFGVTCSAVFSVIIYRITISALM 596

  Fly   601 SILGSENSMTFKVMILPMTAGIIDLIVISLLDMVYSNLAVKLTNYEYCRTQTEYDESLTIKNYVF 665
            ::....:..:...:.:..||.||:|:||.:||.:|..:|..||..|..:|:|.::|.|.:|.:|.
Zfish   597 AMSPDPDVKSNVRVTVTATAVIINLVVILILDEIYGMVAAWLTELEIPKTETNFEERLILKAFVL 661

  Fly   666 QFVNYYSSLFYIAFLKGKFVGYPAKYNRVL-GFRQEECNPGGCLMELCMQLVIIMAGKQAV-NAI 728
            :|:|.|:.:||:||.||:|.|.|..|..|. .:|.|||.|||||:|||:||.|||.|||.: |.:
Zfish   662 KFMNAYAPIFYVAFFKGRFAGRPGDYVYVFHDYRMEECAPGGCLIELCIQLSIIMLGKQLIQNNV 726

  Fly   729 VEMLIP---YLMRTFKELSYRHGWYKSHQDQRLVPY----NQFTEDYNLLPAENNSLYVEYLEMV 786
            .|:.||   .|.||.|:        |..:.:.:|..    .|:..||:|.|.:  .|..||:||:
Zfish   727 FEIGIPKLKKLCRTLKD--------KDREPKEIVEQPGRRQQWHMDYDLEPFD--GLTPEYMEMI 781

  Fly   787 VQFGFITLFSLAFPLAPLLALLNNVIEVRLDAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIAV 851
            :||||::||..:||||||.||||||||:||||.|.:..||||..:|.:|||:|::|::.:.:.:|
Zfish   782 IQFGFVSLFVASFPLAPLFALLNNVIEIRLDAKKFVTELRRPDAVRTKDIGIWYNILSGLGKFSV 846

  Fly   852 ASSAMIIAFSTNLIPKIVYAASMGDP-ELNNYLNFTLAVFNTKDFQVQPLLGGSQHVNETVCRYT 915
            ..:|.:|:|:::.||::||.....:. .::.::|.||:.||..:|:...:...|   :.|||||.
Zfish   847 IINAFVISFTSDFIPRLVYQYMYSETGTMHGFINHTLSYFNVSNFKPGTMPSTS---DITVCRYK 908

  Fly   916 EFRNSPEDPHPYKRPMIYWKILTGRLAFIVIYQNIITMLQGILRWAVPDVSGRLLKRIKRENFLL 980
            ::|..|....||:....||.:|..||.|::::||::.::..::.|.:||:...:.:::|::..||
Zfish   909 DYREPPWSNEPYQFSKQYWSVLAARLGFVILFQNLVIIMSMLVAWLIPDMPKNISEQLKKDKTLL 973

  Fly   981 REHIIEYEKQHAMKLVQT----ELNGQQKSEGELRQRNNETVI---------------------R 1020
            .:..:..||: .::|:|:    :|..:|:.|.: :|.:::|.:                     |
Zfish   974 VDVFLNEEKE-KLQLIQSLFSKDLTNKQQEEHQ-QQVSDKTSLPLQQSQPGFLPPSSSPASTAPR 1036

  Fly  1021 NRDEATSF 1028
            .|..|.||
Zfish  1037 TRARAASF 1044

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_727578.3	Anoct_dimer	183..392	CDD:465044	77/300 (26%)
		Anoctamin	395..976	CDD:461349	231/620 (37%)
ano2b	NP_001314787.1	Anoct_dimer	94..363	CDD:465044	78/303 (26%)
		Anoctamin	366..968	CDD:461349	230/619 (37%)