DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10353 and ano2b

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	NP_001314787.1	Gene:	ano2b / 566373	ZFINID:	ZDB-GENE-060503-62	Length:	1065	Species:	Danio rerio

Alignment Length:	1048	Identity:	336/1048 - (32%)
Similarity:	520/1048 - (49%)	Gaps:	221/1048 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 DDEV---------SRRLLRTSSNISNKDKKLPITYSQWKSRTYRRFDDGKRSVDFVLAY------ 196
            ||.|         |..:|:||.|..:....:.......:.|.|  |.||:|.||:||.:
Zfish    52 DDSVDFIEESLHHSDNMLQTSGNKIHVANNMMDMDQDPRKRLY--FADGRRKVDYVLVFHYRKRS 114

  Fly   197 ---------------NGETQL--EE------HRRKCEI--------------------FEANLQR 218
                           ||...|  ||      .....|:                    ||.:|:.
Zfish   115 SIRGSPSQHRLSIISNGSYHLGVEEKDPEGGKEEPAEVVVDVGPPDPAEGEKIMIREEFEGSLKD 179

  Fly   219 EGLQLEHNKVQRVH---FIKIHAPAEVLYRYAEILKIKV-------------------------- 254
            .||::|.:|..:.|   ||::|||.:||.|.||.|||||
Zfish   180 AGLEIERDKENKAHGHAFIRLHAPWQVLSREAEFLKIKVQTKKSYELREEKGLAATMNEVWRKLN 244

  Fly   255 -PLKP-IPGQDQIFAESAHEFKTCFSRMCKSLFSSVQLNTALFPEREPRIHLEFSRNYLELYDTE 317
             |.:| :|.|:|      ...:|.|...|                        |||:.|.||:.:
Zfish   245 QPFQPKVPHQEQ------ENSRTKFLTHC------------------------FSRDKLHLYNIQ 279

  Fly   318 HPN-FLDASTRYSIINFILQRQRFVEGEETADNLGIEKLVQDGVYTCAYTLHD-----------K 370
            ..: |.|.:||..|:..||:|....   .|...:||..|:.:|||..|:.|||           |
Zfish   280 SKDTFFDNATRSRIVYEILRRTACT---RTCQTMGITTLIANGVYDSAFPLHDGDFHSSGQAEGK 341

  Fly   371 DDRDRLLKEWANISKWKNLQPLDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGVLCFLYGFITW 435
            ::|..|..|||....:...||:|.|:.|||.|:.|||||||.|||:|||.||.|::.|.||:.|.
Zfish   342 NERQLLHDEWARYGAFYKYQPIDLIRKYFGEKIGLYFAWLGVYTQLLIPASVVGIIVFFYGWATV 406

  Fly   436 NSDPISRDICDDNGTI-MCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSMAIWAVVYLE 499
            .::..|:::||:.... |||.|||.||||:|:..|.:::.::|.||..||.||..|::||.::||
Zfish   407 ETNVPSQEMCDETQNFTMCPLCDRVCDYWQLSTACGTARASHLFDNPATVFFAIFMSLWAAMFLE 471

  Fly   500 FWKRYSAGLVHRWGLTGFTHHVEHPRPQY----LARISRTKKLAGKAYEQ----DHTGKRTILDP 556
            .|||....|.:.|.|||.....|||||:|    |.:..|.||......|.    |.:|:   |..
Zfish   472 HWKRRQISLNYSWDLTGMEEEEEHPRPKYETILLQKRQRKKKNKKNKNEPERVVDESGE---LGK 533

  Fly   557 DVPFWSFKF--------------------LPNFTSYSIMVLFIC-ISVIAIAGIIIYRMAQRASH 600
            |.  |..:.                    ||.:......:||:. ::..|:..:||||:...|..
Zfish   534 DK--WRQRLLSAMAAGNPTGHEKLTWRDRLPGYLINISSILFMFGVTCSAVFSVIIYRITISALM 596

  Fly   601 SILGSENSMTFKVMILPMTAGIIDLIVISLLDMVYSNLAVKLTNYEYCRTQTEYDESLTIKNYVF 665
            ::....:..:...:.:..||.||:|:||.:||.:|..:|..||..|..:|:|.::|.|.:|.:|.
Zfish   597 AMSPDPDVKSNVRVTVTATAVIINLVVILILDEIYGMVAAWLTELEIPKTETNFEERLILKAFVL 661

  Fly   666 QFVNYYSSLFYIAFLKGKFVGYPAKYNRVL-GFRQEECNPGGCLMELCMQLVIIMAGKQAV-NAI 728
            :|:|.|:.:||:||.||:|.|.|..|..|. .:|.|||.|||||:|||:||.|||.|||.: |.:
Zfish   662 KFMNAYAPIFYVAFFKGRFAGRPGDYVYVFHDYRMEECAPGGCLIELCIQLSIIMLGKQLIQNNV 726

  Fly   729 VEMLIP---YLMRTFKELSYRHGWYKSHQDQRLVPY----NQFTEDYNLLPAENNSLYVEYLEMV 786
            .|:.||   .|.||.|:        |..:.:.:|..    .|:..||:|.|.:  .|..||:||:
Zfish   727 FEIGIPKLKKLCRTLKD--------KDREPKEIVEQPGRRQQWHMDYDLEPFD--GLTPEYMEMI 781

  Fly   787 VQFGFITLFSLAFPLAPLLALLNNVIEVRLDAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIAV 851
            :||||::||..:||||||.||||||||:||||.|.:..||||..:|.:|||:|::|::.:.:.:|
Zfish   782 IQFGFVSLFVASFPLAPLFALLNNVIEIRLDAKKFVTELRRPDAVRTKDIGIWYNILSGLGKFSV 846

  Fly   852 ASSAMIIAFSTNLIPKIVYAASMGDP-ELNNYLNFTLAVFNTKDFQVQPLLGGSQHVNETVCRYT 915
            ..:|.:|:|:::.||::||.....:. .::.::|.||:.||..:|:...:...|   :.|||||.
Zfish   847 IINAFVISFTSDFIPRLVYQYMYSETGTMHGFINHTLSYFNVSNFKPGTMPSTS---DITVCRYK 908

  Fly   916 EFRNSPEDPHPYKRPMIYWKILTGRLAFIVIYQNIITMLQGILRWAVPDVSGRLLKRIKRENFLL 980
            ::|..|....||:....||.:|..||.|::::||::.::..::.|.:||:...:.:::|::..||
Zfish   909 DYREPPWSNEPYQFSKQYWSVLAARLGFVILFQNLVIIMSMLVAWLIPDMPKNISEQLKKDKTLL 973

  Fly   981 REHIIEYEKQHAMKLVQT----ELNGQQKSEGELRQRNNETVI---------------------R 1020
            .:..:..||: .::|:|:    :|..:|:.|.: :|.:::|.:                     |
Zfish   974 VDVFLNEEKE-KLQLIQSLFSKDLTNKQQEEHQ-QQVSDKTSLPLQQSQPGFLPPSSSPASTAPR 1036

  Fly  1021 NRDEATSF 1028
            .|..|.||
Zfish  1037 TRARAASF 1044

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	77/300 (26%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	231/621 (37%)
ano2b	NP_001314787.1	Anoct_dimer	94..363	CDD:292796	78/303 (26%)
ano2b	NP_001314787.1	Anoctamin	366..968	CDD:282414	230/619 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	1	1.000	-	-		mtm6575
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.920