Protein Alignment CG10353 and ano8b

DIOPT Version :9

• Sequence 1: NP_001245633.1
• Gene: CG10353 / 32148
• FlyBaseID: FBgn0030349
• Length: 1029
• Species: Drosophila melanogaster
• Sequence 2: XP_021335376.1
• Gene: ano8b / 562782
• ZFINID: ZDB-GENE-121024-1
• Length: 1110
• Species: Danio rerio
• Alignment Length: 1207
• Identity: 266/1207 - (22%)
• Similarity: 405/1207 - (33%)
• Gaps: 506/1207 - (41%)

  Fly    35 AAAAAAAHRKSISQSRNTIYHSAVDLAGDEGGGGSGGGRLRLGGGAAAEHAALAWQPGYRQSTAL 99
            ||||||:...:||.|                   |.|                       :|:.|
Zfish     6 AAAAAASSASNISSS-------------------SDG-----------------------ESSRL 28

  Fly   100 EHLNGGGGGGGDHTDAAIAAQMIALQNGRNHLPTGIGVTGDGGQGGGDDEVSRRLLRTSSNISNK 164
            .|...|        ||..|.|.   |:......|..||.        |....:|||:...:|
Zfish    29 RHRAQG--------DAERAEQQ---QHTAAPQTTSAGVL--------DKLFGKRLLQAGRHI--- 71

  Fly   165 DKKLPITYSQWKSRTYRRFDDGKRSVDFVLAYNGETQLEEHRRKCEIFEANLQREG-----LQLE 224
                 :::..|....      ...:.|.::.:...|  ::|..   ::..|..|.|     :|:.
Zfish    72 -----MSHKSWMKTV------PTENCDVLMTFPDTT--DDHTL---LWLLNHIRLGIPELIIQIR 120

  Fly   225 HNKVQRVHFIKIHAPAEVLYRYAEILKIKVPLKP-IPGQDQIFA-ESAHEFKTCFSRMCKSLFSS 287
            |:|..|::...:.|..|.|.|.||.:.::..:|| ..|..:.|: |..:.::...|.:|
Zfish   121 HHKHTRMYAFFVTATYENLLRGAEEMGLQKAVKPEFGGGSRSFSCEEDYIYENIESELC------ 179

  Fly   288 VQLNTALFPEREPRIHLEFSRNYLELYDTEHPNFLDASTRYSIINFILQRQR-----------FV 341
                                             |..:..|.|||.:.|...|           |:
Zfish   180 ---------------------------------FFTSQERQSIIKYWLDNLRAKHGEALHNIHFL 211

  Fly   342 EGEETADNLGIEKLVQDGVYTCAYTLHDKDDRDRLLKEWANISKWKNLQPLDQIKDYFGAKVALY 406
            ||:..     |.:|...||....:.||::....:|:|.|......|  ||||.|.||||.|:|:|
Zfish   212 EGQPI-----IPELRARGVIQQVFPLHEQRILGQLMKSWVQAVCEK--QPLDDICDYFGVKIAMY 269

  Fly   407 FAWLGFY-TQMLIPISVFGVLCFLYGFITW---NSDPISRDICDDNGTIMCPQCDRSCDYWRLNE 467
            ||||||| |.||.|..:        ||:.|   .||..|||||
Zfish   270 FAWLGFYTTSMLYPAVI--------GFVLWMLTESDQTSRDIC---------------------- 304

  Fly   468 TCTSSKFNYLIDNNMTVVFAFSMAIWAVVYLEFWKRYSAGLVHRWG-LTGFTHHVEHPRPQYLAR 531
             |              ||||....:||.::||.|||..|.|.::|| |......:|.||||:..
Zfish   305 -C--------------VVFALFNVVWATLFLERWKRRGAELAYKWGTLNTPAESLEEPRPQFRG- 353

  Fly   532 ISRTKKLAGKAYEQDHTGKRTILDPDVPFWS---FKFLPNFTSYSIMVLFICISVIAIAGIIIYR 593
            :.|...:.|  .|:.:          .|.|.   |::|.:|.     |..:|:..:.:|.::.:.
Zfish   354 VKRCSPVTG--CEEFY----------YPPWRRRVFRWLVSFP-----VCILCLCFVFLAMLVCFE 401

  Fly   594 MAQRASHSILGSENSMTFKVMILPMTAGIIDLIVISL----LDMVYSNLAVKLTNYEYCRTQTEY 654
            :.:    .::|        :..||..|..|..|::::    .|.||..:|..|.:.|..|.|:.|
Zfish   402 LQE----FVMG--------IKELPRVARFIPKIMLAITVTACDEVYRKIACWLNDMENYRLQSAY 454

  Fly   655 DESLTIKNYVFQFVNYYSSLFYIAFLKGKFVGYPAKYNRVLGFRQEECNPGGCLMELCMQLVIIM 719
            :::|.||..:|||||.|.|||||.|       |.....|              |.|:...|:||
Zfish   455 EKNLIIKMVLFQFVNSYLSLFYIGF-------YLKDMER--------------LKEMLATLLII- 497

  Fly   720 AGKQAVNAIVEMLIPYLMRTFK--ELSYRHGW--------------------------------- 749
              :|.|..:.|:|.|||....:  ||:.|..|
Zfish   498 --RQFVQNMKEVLQPYLAERHRLGELTLRAVWELLVSALLKYGRLAAGRAQVSPSDPTVLGPGLR 560

  Fly   750 -----YKSHQDQR---------------------------------------------------- 757
                 .:.|||:|
Zfish   561 GPQMGEEGHQDRRERKCLNGGCGVPDEDMEEEHGERHSEEENESESLIDCGLKLRKVSFIEKVER 625

  Fly   758 -------------------------LVPYNQF----TEDYNLLP-------------AENNS--- 777
                                     :.|.:.|    .||.|..|             .||:|
Zfish   626 KSASCVSPVDDSFLEEGSPTMVERGMDPASVFEMCDDEDENGAPEMKELAAEPLPTGVENSSSVK 690

  Fly   778 ----------------------------------------------LYVEYLEMVVQFGFITLFS 796
                                                          .:.:|.||.||||::.|||
Zfish   691 LRKRGRSLERADSKTKRDSWMDPPEEQETNTLTQAEVEGCMQTYQDTFQDYQEMFVQFGYVVLFS 755

  Fly   797 LAFPLAPLLALLNNVIEVRLDAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAFS 861
            .|||||.:.||:||:||:|.||.|:...|:||.|:|...||.|.::|..:..||:..:..:|
Zfish   756 SAFPLAAMCALINNIIEIRSDAFKLCTSLQRPFGLRVASIGQWQTVMEAMGLIAIIVNCYLI--- 817

  Fly   862 TNLIPKIVYAASMGDPELNNYLNFTLAVFNTKDFQVQPLLGGSQHVNETVCRYTEFRNSPEDPHP 926
                      ...|                    |:|.|.                        |
Zfish   818 ----------GQCG--------------------QLQRLF------------------------P 828

  Fly   927 YKRPMIYWKILTGRLAFIVIYQNIITMLQGILRWAVPDVSGRLLKRIKRENFLLREHIIEYEKQH 991
            :..|.:       .:..|||.::...:|:.|:..|:||:...:.:.:.:..|..:|...::|:|.
Zfish   829 WLSPEM-------AIISIVILEHFAVLLKYIIHVAIPDIPSWVGEEMAKLEFQRKEAFKKHERQA 886

  Fly   992 AMKLVQTELNGQQKSEGELRQRNNE-TVIRNRDEATS 1027
            .....|.:   ::|.|.|.|||..| ...|:||:..|
Zfish   887 QQHFQQQQ---RRKREEEERQRQAEYQARRDRDDGRS 920

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	44/226 (19%)
		Anoctamin	395..977	CDD:282414	174/776 (22%)
ano8b	XP_021335376.1	Anoctamin	258..870	CDD:309610	174/774 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950