DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10353 and LOC562630

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	XP_001921968.4	Gene:	LOC562630 / 562630	-ID:	-	Length:	817	Species:	Danio rerio

Alignment Length:	937	Identity:	264/937 - (28%)
Similarity:	436/937 - (46%)	Gaps:	188/937 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   139 GDGGQGGGDDEVSRRLLRTSSNIS-NKDKKLPITYSQWKSRTYRRFDDGKRSVDFVL-AYNGETQ 201
            |...||..|      ||.|...:: |.::.|.:...| :|.||          |:|| |...:.:
Zfish     7 GHRRQGSID------LLETIGIVNENGNENLSVVPVQ-RSLTY----------DYVLVAKTSDDE 54

  Fly   202 LEEHRRKCEIFEANLQREGLQL-EHNKVQRVHFIKIHAPAEVLYRYAEILKIKVPLKPIPGQDQI 265
            .....||...|...|:::.|.: ::.......|..|.|...:...|..:||:
Zfish    55 NSHSARKRNAFIQALKQKQLSVKKYTNYDEKMFYCIRAADSIFETYRYLLKV------------- 106

  Fly   266 FAESAHEFKTCFSRMCKSLFSSVQLNTALFPEREPRIHLEFSRNYLELYDTEHPNFLDASTRYSI 330
                        |..|.                               :..|....:..|||..:
Zfish   107 ------------SDACN-------------------------------WSCEQKGTVPQSTRIRV 128

  Fly   331 INFILQRQRFVEGEETADNLGIEK----LVQDGVYTCAYTLHDKDDRDRLLKEWANISKWKNLQP 391
            ::||:.       ..:.|..|:.:    |::..|:...:.||:|.::..|.|.||..|.....||
Zfish   129 VDFIVH-------HTSIDTQGVPEYLPDLMKKDVFETYFCLHEKREQKELKKSWARWSATFRGQP 186

  Fly   392 LDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGVLCFLYGFITWNSDPISRDICDDNGTIMCPQC 456
            :..:::|.|.||||||.|||:||.:|||.||.|::.||||...:::.|:.:::|:.|.| |||.|
Zfish   187 ITNVRNYLGEKVALYFLWLGWYTFLLIPASVIGIIVFLYGLAFYSTSPLIQEVCNSNIT-MCPLC 250

  Fly   457 DRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSMAIWAVVYLEFWKRYSAGLVHRWGLTGFTHHV 521
            :..|..|.|::||..:|.:.|.||..||.||..||:||.|:||||||:.:..|..|.:..:....
Zfish   251 NNKCKVWNLSDTCMYAKVSLLFDNAGTVAFAMFMAVWATVFLEFWKRHRSSFVCAWKVYDWCEEE 315

  Fly   522 EHPRPQYLARISRTKKLAGKAYEQDHTGKRTILDPDVPFWSFKFLPNFTSYSIMVLFICISVIAI 586
            |    :.:..|........|.:...:.....:|                  :::.|.:.|.:...
Zfish   316 E----ELIMEIVNNAACEPKMHRHSYLRSTIVL------------------ALVTLMLLIIIGLT 358

  Fly   587 AGIIIYR------MAQRASHSILGSENSMTFKVMILPMTAGIIDLIVISLLDMVYSNLAVKLTNY 645
            ..::::|      :|:::...::| :||.|..:|:    ..::..|.|:::..|...:|:||:..
Zfish   359 HALVVFRVIATVLLAEKSQWQLIG-DNSQTVALML----GAVLHYITITVMTRVNCMVAMKLSEI 418

  Fly   646 EYCRTQTEYDESLTIKNYVFQFVNYYSSLFYIAFLKGKFVGYPAKYNRVLG-FRQEECNPGGCLM 709
            |...:....:.|.|:|.::|||...:|||.|.||..|:..|:|..|.::.| :|.|||:|.|||.
Zfish   419 ENKHSHAAIERSFTVKMFIFQFFTMFSSLIYTAFFLGRINGHPGGYVKISGIWRLEECHPSGCLT 483

  Fly   710 ELCMQLVIIMAGKQAVNAIVEMLIPYLMRTFKELSYRHGWYKSHQDQRLV--------------- 759
            :|.:|:.|||..||..|.|.|...|:..|          |....::|:|:
Zfish   484 DLFIQMSIIMVLKQTFNNIFEYSGPWFRR----------WLNRKKNQKLLRRCLKCYKKECMDAV 538

  Fly   760 ---------PYNQFTEDYNLLPAENNSLYVEYLEMVVQFGFITLFSLAFPLAPLLALLNNVIEVR 815
                     .......:|:|:..:..||:.|:||||:||.|.|:|..|||||||||||||:||:|
Zfish   539 EASELCDNCKLEDLHRNYSLIQTDRFSLFNEFLEMVIQFSFTTIFVAAFPLAPLLALLNNIIEIR 603

  Fly   816 LDAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAFSTNLIPKIVY-----AASMG 875
            ||||||:...||.|..:|.|||||..::..::.:||.::.::|..|::.||::||     ..:.|
Zfish   604 LDAIKMVSLERRLVPTKANDIGVWTDVLEAISALAVIANGLVIGISSDFIPRLVYQYYYGPCASG 668

  Fly   876 DPE----LNNYLNFTLAVFNTKDFQVQPLLGGSQHVNE-----TVCRYTEFRNSPEDPHPYKRPM 931
            :|.    :..|:|.||:|.|..|.:|......:|.:.:     |.|||.::|:| ||   :....
Zfish   669 NPAGVDCMVGYINNTLSVANVSDQRVSEDFKPNQLITDSGESVTHCRYRDYRSS-ED---FSLTN 729

  Fly   932 IYWKILTGRLAFIVIYQNIITMLQGILRWAVP----DVSG-RL---LKRIKRENFLLREHIIEYE 988
            .:|.||..||.||:::::::.|.:.:..|.||    ||:. ||   |.|:|:|   ||:   :..
Zfish   730 QFWVILASRLVFIILFEHVVVMFKCVTSWFVPNSPLDVTNERLFDKLTRLKQE---LRD---QRT 788

  Fly   989 KQHAMKLVQTELNGQQKSEGELRQRNN 1015
            :|.....:....|.::.|:....::.|
Zfish   789 QQDTFSKLNENGNSRKPSKRNKSKKQN 815

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	36/214 (17%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	207/634 (33%)
LOC562630	XP_001921968.4	Anoctamin	190..771	CDD:282414	202/622 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910