Protein Alignment CG10353 and ano5b

DIOPT Version :10

• Sequence 1: NP_727578.3
• Gene: CG10353 / 32148
• FlyBaseID: FBgn0030349
• Length: 1029
• Species: Drosophila melanogaster
• Sequence 2: XP_005168948.1
• Gene: ano5b / 560102
• ZFINID: ZDB-GENE-061215-108
• Length: 930
• Species: Danio rerio
• Alignment Length: 924
• Identity: 343/924 - (37%)
• Similarity: 513/924 - (55%)
• Gaps: 130/924 - (14%)

  Fly   152 RRLLRTSSN-----ISNKDKKLP-----ITYSQWKSRTYRRFDDGKRSVDFVLAY----NGETQL 202
            ||.|...:|     ||::..:||     ..:.|.:...:  |.||.|.:||||:|    .|:.:.
Zfish    35 RRTLPAGNNGSINSISDRGIQLPGHREIDKFDQNRDSVF--FKDGVRRIDFVLSYVDDKEGDKKA 97

  Fly   203 EEHRRKCEIFEANLQREGLQLE-----HNKVQRVHFIKIHAPAEVLYRYAEILKIKVPLK--PIP 260
            |..|.    |||||::.||:||     .:..::.|::|||||.|||..||::||||||.|  .||
Zfish    98 ERRRE----FEANLEKAGLELETEDKSESDDRKTHYLKIHAPWEVLATYADVLKIKVPFKVSDIP 158

  Fly   261 GQDQIFAE-SAHEFKTCFSRMCKSLFSSVQLNTALFPER----EP-RIHLEFSRNYLELY----- 314
            ...::..| .:|.|:                    .||.    || .....|.::.::.:
Zfish   159 KAREVPLEWLSHPFR--------------------LPENIMRPEPDYFTAPFDKSKVDFFLIDDK 203

  Fly   315 DTEHPNFLDASTRYSIINFILQR-QRFVEGEETADNLGIEKLVQDGVYTCAYTLHD--------- 369
            ||    |...|||..|:.:||.| ..:.|..:..|..||.:|:.:|.||.||.|||
Zfish   204 DT----FFPPSTRNRIVYYILTRCPYYKEDRKEKDKTGINRLLNNGTYTSAYPLHDCRYWKKAQD 264

  Fly   370 ---KDDRDRLLKEWANISKWKNLQPLDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGVLCFLYG 431
               :.:|..|.:.||....:...|||:.||.|:|.|:.:|||||||||:||...:|.||:||:||
Zfish   265 MQCESERYHLYRYWARFLCFYKEQPLNLIKKYYGEKIGIYFAWLGFYTEMLFYAAVMGVICFVYG 329

  Fly   432 FITWNSDPISRDICDD--NGTI-MCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSMAIW 493
            .:::..:..|::|||.  .|.| |||.||:.|.||:||.||.||..::|.||..||.||..|.||
Zfish   330 VLSYEDNITSKEICDPKIGGMIVMCPLCDKKCSYWKLNSTCLSSWQSHLFDNEGTVFFAMFMGIW 394

  Fly   494 AVVYLEFWKRYSAGLVHRWGLTGFTHHVEHPRPQYLARISRTKKLAGKAYEQDHTGKR-----TI 553
            ..::||||||..|.|.:.|.|..|    |..:.|...|         ..|||..||:|     ..
Zfish   395 VTLFLEFWKRRQARLEYEWDLVDF----EEEQQQLQIR---------PEYEQKCTGRRLNRITQE 446

  Fly   554 LDPDVPFWSFKFLPNFTSYSIMVLFICISVIAIAGIIIYRMAQRASHSILGSENSMTFKV----- 613
            ::|.:||.| |......|.:.::.:.|:.|..|.|:|.||:|..|:.:.: .::|.|.|:
Zfish   447 MEPYLPFPS-KCARFCLSGATVLFWTCLIVACIMGVIAYRLAVYAAFASV-MKDSSTSKIQLVGS 509

  Fly   614 MILP-----MTAGIIDLIVISLLDMVYSNLAVKLTNYEYCRTQTEYDESLTIKNYVFQFVNYYSS 673
            :|.|     :||..|:.::|.:|:.:|.::|:.:|:.|..:|..||:..||:|.::|||||||||
Zfish   510 LITPQLATSVTASCINFVIILILNFLYEHVAIWITDMEIPKTHLEYENKLTMKMFMFQFVNYYSS 574

  Fly   674 LFYIAFLKGKFVGYPAKYNRVLG----FRQEECNPGGCLMELCMQLVIIMAGKQAVNAIVEMLIP 734
            .||:||.||||||||..|:.:.|    .|.|||.|||||:||..||:|:|||||.|..:.|.|:|
Zfish   575 CFYVAFFKGKFVGYPGNYSYMFGKWSTLRNEECAPGGCLIELTTQLLIVMAGKQMVGNVQEALLP 639

  Fly   735 YLMRTFKELSYRHGWYKSHQDQRLVPYNQFTEDYNLLPAENNSLYVEYLEMVVQFGFITLFSLAF 799
             |:|.:  .|.|.|  :||.:.   .|:::.:|::|.......|:.||||||:||||||||..:|
Zfish   640 -LVRNW--WSSRKG--RSHPES---TYSRWEQDHDLQNFSQFGLFYEYLEMVIQFGFITLFVASF 696

  Fly   800 PLAPLLALLNNVIEVRLDAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAFSTNL 864
            ||||||||.||::|||:||.|.....|||:..:||:||.|..|:.||..::|.::|.|:||::::
Zfish   697 PLAPLLALFNNILEVRVDAWKFTTQFRRPMAAKARNIGAWEEILNVVAIMSVVTNAFIMAFTSDM 761

  Fly   865 IPKIV--YAASMG-DPELNNYLNFTLAVFNTKDFQVQPLLGGSQHVN------ETVCRYTEFRNS 920
            ||::|  ||...| :..:..|:..:|:::|........|....::.:      .|.|||.::|..
Zfish   762 IPRLVYLYAYHPGIEANMTGYITNSLSIYNISQIPEDNLPEAGENPSWFNSSTITTCRYRDYRYP 826

  Fly   921 PEDPHPYKRPMIYWKILTGRLAFIVIYQNIITMLQGILRWAVPDVSGRLLKRIKRENFLLREHII 985
            |.....|...|.:|.||..:||||:|.::::.:::..:.|.:|||...:..|||||.||::|::.
Zfish   827 PGHLRQYTHTMQFWHILAAKLAFIIIMEHVVFVVKFFVAWLIPDVPSEVKARIKRERFLVQEYLH 891

  Fly   986 EYE-KQHAMKLVQT 998
            .|| ::..|:|.|:
Zfish   892 NYEVEKLKMQLSQS 905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_727578.3	Anoct_dimer	183..392	CDD:465044	77/243 (32%)
		Anoctamin	395..976	CDD:461349	245/611 (40%)
ano5b	XP_005168948.1	Anoct_dimer	73..290	CDD:465044	77/246 (31%)
		Anoctamin	293..882	CDD:461349	245/611 (40%)