DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10353 and ano5b

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	XP_005168948.1	Gene:	ano5b / 560102	ZFINID:	ZDB-GENE-061215-108	Length:	930	Species:	Danio rerio

Alignment Length:	924	Identity:	343/924 - (37%)
Similarity:	513/924 - (55%)	Gaps:	130/924 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 RRLLRTSSN-----ISNKDKKLP-----ITYSQWKSRTYRRFDDGKRSVDFVLAY----NGETQL 202
            ||.|...:|     ||::..:||     ..:.|.:...:  |.||.|.:||||:|    .|:.:.
Zfish    35 RRTLPAGNNGSINSISDRGIQLPGHREIDKFDQNRDSVF--FKDGVRRIDFVLSYVDDKEGDKKA 97

  Fly   203 EEHRRKCEIFEANLQREGLQLE-----HNKVQRVHFIKIHAPAEVLYRYAEILKIKVPLK--PIP 260
            |..|.    |||||::.||:||     .:..::.|::|||||.|||..||::||||||.|  .||
Zfish    98 ERRRE----FEANLEKAGLELETEDKSESDDRKTHYLKIHAPWEVLATYADVLKIKVPFKVSDIP 158

  Fly   261 GQDQIFAE-SAHEFKTCFSRMCKSLFSSVQLNTALFPER----EP-RIHLEFSRNYLELY----- 314
            ...::..| .:|.|:                    .||.    || .....|.::.::.:
Zfish   159 KAREVPLEWLSHPFR--------------------LPENIMRPEPDYFTAPFDKSKVDFFLIDDK 203

  Fly   315 DTEHPNFLDASTRYSIINFILQR-QRFVEGEETADNLGIEKLVQDGVYTCAYTLHD--------- 369
            ||    |...|||..|:.:||.| ..:.|..:..|..||.:|:.:|.||.||.|||
Zfish   204 DT----FFPPSTRNRIVYYILTRCPYYKEDRKEKDKTGINRLLNNGTYTSAYPLHDCRYWKKAQD 264

  Fly   370 ---KDDRDRLLKEWANISKWKNLQPLDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGVLCFLYG 431
               :.:|..|.:.||....:...|||:.||.|:|.|:.:|||||||||:||...:|.||:||:||
Zfish   265 MQCESERYHLYRYWARFLCFYKEQPLNLIKKYYGEKIGIYFAWLGFYTEMLFYAAVMGVICFVYG 329

  Fly   432 FITWNSDPISRDICDD--NGTI-MCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSMAIW 493
            .:::..:..|::|||.  .|.| |||.||:.|.||:||.||.||..::|.||..||.||..|.||
Zfish   330 VLSYEDNITSKEICDPKIGGMIVMCPLCDKKCSYWKLNSTCLSSWQSHLFDNEGTVFFAMFMGIW 394

  Fly   494 AVVYLEFWKRYSAGLVHRWGLTGFTHHVEHPRPQYLARISRTKKLAGKAYEQDHTGKR-----TI 553
            ..::||||||..|.|.:.|.|..|    |..:.|...|         ..|||..||:|     ..
Zfish   395 VTLFLEFWKRRQARLEYEWDLVDF----EEEQQQLQIR---------PEYEQKCTGRRLNRITQE 446

  Fly   554 LDPDVPFWSFKFLPNFTSYSIMVLFICISVIAIAGIIIYRMAQRASHSILGSENSMTFKV----- 613
            ::|.:||.| |......|.:.::.:.|:.|..|.|:|.||:|..|:.:.: .::|.|.|:
Zfish   447 MEPYLPFPS-KCARFCLSGATVLFWTCLIVACIMGVIAYRLAVYAAFASV-MKDSSTSKIQLVGS 509

  Fly   614 MILP-----MTAGIIDLIVISLLDMVYSNLAVKLTNYEYCRTQTEYDESLTIKNYVFQFVNYYSS 673
            :|.|     :||..|:.::|.:|:.:|.::|:.:|:.|..:|..||:..||:|.::|||||||||
Zfish   510 LITPQLATSVTASCINFVIILILNFLYEHVAIWITDMEIPKTHLEYENKLTMKMFMFQFVNYYSS 574

  Fly   674 LFYIAFLKGKFVGYPAKYNRVLG----FRQEECNPGGCLMELCMQLVIIMAGKQAVNAIVEMLIP 734
            .||:||.||||||||..|:.:.|    .|.|||.|||||:||..||:|:|||||.|..:.|.|:|
Zfish   575 CFYVAFFKGKFVGYPGNYSYMFGKWSTLRNEECAPGGCLIELTTQLLIVMAGKQMVGNVQEALLP 639

  Fly   735 YLMRTFKELSYRHGWYKSHQDQRLVPYNQFTEDYNLLPAENNSLYVEYLEMVVQFGFITLFSLAF 799
             |:|.:  .|.|.|  :||.:.   .|:::.:|::|.......|:.||||||:||||||||..:|
Zfish   640 -LVRNW--WSSRKG--RSHPES---TYSRWEQDHDLQNFSQFGLFYEYLEMVIQFGFITLFVASF 696

  Fly   800 PLAPLLALLNNVIEVRLDAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAFSTNL 864
            ||||||||.||::|||:||.|.....|||:..:||:||.|..|:.||..::|.::|.|:||::::
Zfish   697 PLAPLLALFNNILEVRVDAWKFTTQFRRPMAAKARNIGAWEEILNVVAIMSVVTNAFIMAFTSDM 761

  Fly   865 IPKIV--YAASMG-DPELNNYLNFTLAVFNTKDFQVQPLLGGSQHVN------ETVCRYTEFRNS 920
            ||::|  ||...| :..:..|:..:|:::|........|....::.:      .|.|||.::|..
Zfish   762 IPRLVYLYAYHPGIEANMTGYITNSLSIYNISQIPEDNLPEAGENPSWFNSSTITTCRYRDYRYP 826

  Fly   921 PEDPHPYKRPMIYWKILTGRLAFIVIYQNIITMLQGILRWAVPDVSGRLLKRIKRENFLLREHII 985
            |.....|...|.:|.||..:||||:|.::::.:::..:.|.:|||...:..|||||.||::|::.
Zfish   827 PGHLRQYTHTMQFWHILAAKLAFIIIMEHVVFVVKFFVAWLIPDVPSEVKARIKRERFLVQEYLH 891

  Fly   986 EYE-KQHAMKLVQT 998
            .|| ::..|:|.|:
Zfish   892 NYEVEKLKMQLSQS 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	77/243 (32%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	246/612 (40%)
ano5b	XP_005168948.1	Anoct_dimer	73..290	CDD:292796	77/246 (31%)
ano5b	XP_005168948.1	Anoctamin	293..883	CDD:282414	246/612 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2514
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.780