DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10353 and ano7

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	XP_009289708.1	Gene:	ano7 / 556876	ZFINID:	ZDB-GENE-130530-576	Length:	883	Species:	Danio rerio

Alignment Length:	924	Identity:	314/924 - (33%)
Similarity:	471/924 - (50%)	Gaps:	167/924 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 FDDGKRSVDFVLAY----------NGE-----TQLEEHRRKCEIFEANLQREGLQLEHNKV---- 228
            |.||..::||||.:          :|:     :..:.||:....|.:.||..||..|..:|
Zfish    42 FSDGVTTIDFVLVWEESGSPLKSADGDELSFSSSRDTHRKWRTEFLSKLQEAGLHQEMKEVVQGK 106

  Fly   229 QRVHFIKIHAPAEVLYRYAEILKIKVPLK----PIPGQDQIFAESAH--------------EFKT 275
            .:..::.:.||..||..|||.:.::|||:    ||....:...|..|              ::.|
Zfish   107 TKTTYVLLSAPWNVLCYYAEEISLRVPLQVVTTPISNWSETILEKLHIPNIMAQDVPNYPPDYYT 171

  Fly   276 CFSRMCKSLFSSVQLNTALFPEREPRIHLEFSRNYLELYDTEHPNFLDASTRYSIINFILQRQRF 340
            |       .|.:.:|...|..|.:               ||    |...:.|:.|:..||.|..:
Zfish   172 C-------PFRTTKLERFLGHENK---------------DT----FFKTTQRHQILYEILARTPY 210

  Fly   341 VEGEETADNLGIEKLVQDGVYTCAYTLHD--------KDD------RDRLLKEWANISKWKNLQP 391
              |......:||.:||.:.|.|.|:.||:        ::|      |..|...||..:.|:..||
Zfish   211 --GALKRGEVGIGRLVSEKVLTAAFPLHEGPFQLPKTQEDPQCLNMRQILHHYWARWACWRKYQP 273

  Fly   392 LDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGVLCFLYGFITWNSDPISRDICDD-NGTIMCPQ 455
            ||.|::|||.|:|||||||||||..|:|.:|.|.:.||:|.....:|..:.::|.. |..||||.
Zfish   274 LDHIREYFGEKIALYFAWLGFYTGWLLPAAVVGFIIFLFGIWLMVTDVPAEELCSSGNAFIMCPL 338

  Fly   456 CDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSMAIWAVVYLEFWKRYSAGLVHRWGLTGFTHH 520
            |: .|.:|.|:..|.:.|...|.||..||.|:..|::|||.:||:|||.|:.|.|||..:.|...
Zfish   339 CN-ICSHWNLSSICYTYKAGLLFDNGGTVFFSIFMSLWAVTFLEYWKRTSSILSHRWDCSEFEEI 402

  Fly   521 VEHPRPQYLARISRTKKLAGKAYEQDHTGKRTILDPDVPFWSFKFLPNFTSYSIMVLFICISVIA 585
            .|.|||::.|       ||........||......|:    :.:.....|...:::|.|.|.:|.
Zfish   403 EERPRPEFTA-------LAPMTVRNPVTGAEEPYFPE----ARRLSRTLTGNMVIILMISIVLIF 456

  Fly   586 IAGIIIYRMAQRASHSILGSENSMTFKVM----ILPMTAGIIDLIVISLLDMVYSNLAVKLTNYE 646
            :..||:||...    ||:...:...|.:.    |..:|..:::|:||.||..:|:.||..||.:|
Zfish   457 LMAIILYRTIL----SIIIYRSQSAFFIFSAGRIASLTGSMLNLLVILLLSRLYTYLAQCLTRWE 517

  Fly   647 YCRTQTEYDESLTIKNYVFQFVNYYSSLFYIAFLKGKFVGYPAKYNRVLGFRQEECNPGGCLMEL 711
            ..||||||:.:..:|.::|||||:|||..||||.||:|||||..||.:||.|.|:|...|||:||
Zfish   518 MHRTQTEYENAFILKVFIFQFVNFYSSPVYIAFFKGRFVGYPGSYNTLLGIRNEDCGASGCLIEL 582

  Fly   712 CMQLVIIMAGKQAVNAIVEMLIPYLMRTFKELSYRHGWYKSHQDQRLVP---------------Y 761
            ..:|::||.|||.::.|.|.::|.| :|:        |:|    ::|.|               .
Zfish   583 AQELLVIMVGKQVISNIQEFVLPKL-KTW--------WHK----RKLKPARSQEVIDEPDTNSQI 634

  Fly   762 NQFTEDYNLLPAENNSLYVEYLEMVVQFGFITLFSLAFPLAPLLALLNNVIEVRLDAIKMLRFLR 826
            |.:..||.||..|  .|:.||||||:||||||:|..|.|||||.||:||.:||||||.|.:...|
Zfish   635 NPWENDYQLLVCE--GLFDEYLEMVLQFGFITIFVAACPLAPLFALINNWVEVRLDAQKFVCEYR 697

  Fly   827 RPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAFSTNLIPKIVYAASMGDPELNNYLNFTLAVFN 891
            |||..||:|||:|.:|:..::.:||.|:|.:|||:::.:|::.|..:.|  .::.|:||||:|..
Zfish   698 RPVVERAQDIGIWLTILQFISYLAVISNAFLIAFTSDFLPRLFYRYTAG--SMSGYINFTLSVAP 760

  Fly   892 TKDFQVQPLLGGSQHVNETVCRYTEFRN----SPEDPHPYKRPMIYWKILTGRLAFIVIYQNIIT 952
            ....|           ||..|||...|:    :.:|         |:.:|..||:|::|:::::.
Zfish   761 ANFTQ-----------NEMSCRYRGLRDEKGQNTQD---------YYHLLAIRLSFVIIFEHVVL 805

  Fly   953 MLQGILRWAVPDVSGRLLKRIKRENFLLREHIIEYEKQHAMKLVQTELNGQQKSEGELRQR---- 1013
            ::..|:.|.|||:...:..:||||:::.:|.:.  |.|...|.|..|: |:|..  |||||
Zfish   806 LIGRIIDWIVPDIPEEVEIKIKREHYMAKEALA--ENQSLSKSVLEEM-GRQNF--ELRQRIRTQ 865

  Fly  1014 --NNETVIRNRDEA 1025
              .|.....:.|||
Zfish   866 SPTNNMSPTSEDEA 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	62/259 (24%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	231/605 (38%)
ano7	XP_009289708.1	Anoct_dimer	42..274	CDD:292796	62/259 (24%)
ano7	XP_009289708.1	Anoctamin	277..830	CDD:282414	231/605 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920