Protein Alignment CG10353 and ano7

DIOPT Version :10

• Sequence 1: NP_727578.3
• Gene: CG10353 / 32148
• FlyBaseID: FBgn0030349
• Length: 1029
• Species: Drosophila melanogaster
• Sequence 2: XP_009289708.1
• Gene: ano7 / 556876
• ZFINID: ZDB-GENE-130530-576
• Length: 883
• Species: Danio rerio
• Alignment Length: 924
• Identity: 314/924 - (33%)
• Similarity: 471/924 - (50%)
• Gaps: 167/924 - (18%)

  Fly   183 FDDGKRSVDFVLAY----------NGE-----TQLEEHRRKCEIFEANLQREGLQLEHNKV---- 228
            |.||..::||||.:          :|:     :..:.||:....|.:.||..||..|..:|
Zfish    42 FSDGVTTIDFVLVWEESGSPLKSADGDELSFSSSRDTHRKWRTEFLSKLQEAGLHQEMKEVVQGK 106

  Fly   229 QRVHFIKIHAPAEVLYRYAEILKIKVPLK----PIPGQDQIFAESAH--------------EFKT 275
            .:..::.:.||..||..|||.:.::|||:    ||....:...|..|              ::.|
Zfish   107 TKTTYVLLSAPWNVLCYYAEEISLRVPLQVVTTPISNWSETILEKLHIPNIMAQDVPNYPPDYYT 171

  Fly   276 CFSRMCKSLFSSVQLNTALFPEREPRIHLEFSRNYLELYDTEHPNFLDASTRYSIINFILQRQRF 340
            |       .|.:.:|...|..|.:               ||    |...:.|:.|:..||.|..:
Zfish   172 C-------PFRTTKLERFLGHENK---------------DT----FFKTTQRHQILYEILARTPY 210

  Fly   341 VEGEETADNLGIEKLVQDGVYTCAYTLHD--------KDD------RDRLLKEWANISKWKNLQP 391
              |......:||.:||.:.|.|.|:.||:        ::|      |..|...||..:.|:..||
Zfish   211 --GALKRGEVGIGRLVSEKVLTAAFPLHEGPFQLPKTQEDPQCLNMRQILHHYWARWACWRKYQP 273

  Fly   392 LDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGVLCFLYGFITWNSDPISRDICDD-NGTIMCPQ 455
            ||.|::|||.|:|||||||||||..|:|.:|.|.:.||:|.....:|..:.::|.. |..||||.
Zfish   274 LDHIREYFGEKIALYFAWLGFYTGWLLPAAVVGFIIFLFGIWLMVTDVPAEELCSSGNAFIMCPL 338

  Fly   456 CDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSMAIWAVVYLEFWKRYSAGLVHRWGLTGFTHH 520
            |: .|.:|.|:..|.:.|...|.||..||.|:..|::|||.:||:|||.|:.|.|||..:.|...
Zfish   339 CN-ICSHWNLSSICYTYKAGLLFDNGGTVFFSIFMSLWAVTFLEYWKRTSSILSHRWDCSEFEEI 402

  Fly   521 VEHPRPQYLARISRTKKLAGKAYEQDHTGKRTILDPDVPFWSFKFLPNFTSYSIMVLFICISVIA 585
            .|.|||::.|       ||........||......|:    :.:.....|...:::|.|.|.:|.
Zfish   403 EERPRPEFTA-------LAPMTVRNPVTGAEEPYFPE----ARRLSRTLTGNMVIILMISIVLIF 456

  Fly   586 IAGIIIYRMAQRASHSILGSENSMTFKVM----ILPMTAGIIDLIVISLLDMVYSNLAVKLTNYE 646
            :..||:||...    ||:...:...|.:.    |..:|..:::|:||.||..:|:.||..||.:|
Zfish   457 LMAIILYRTIL----SIIIYRSQSAFFIFSAGRIASLTGSMLNLLVILLLSRLYTYLAQCLTRWE 517

  Fly   647 YCRTQTEYDESLTIKNYVFQFVNYYSSLFYIAFLKGKFVGYPAKYNRVLGFRQEECNPGGCLMEL 711
            ..||||||:.:..:|.::|||||:|||..||||.||:|||||..||.:||.|.|:|...|||:||
Zfish   518 MHRTQTEYENAFILKVFIFQFVNFYSSPVYIAFFKGRFVGYPGSYNTLLGIRNEDCGASGCLIEL 582

  Fly   712 CMQLVIIMAGKQAVNAIVEMLIPYLMRTFKELSYRHGWYKSHQDQRLVP---------------Y 761
            ..:|::||.|||.::.|.|.::|.| :|:        |:|    ::|.|               .
Zfish   583 AQELLVIMVGKQVISNIQEFVLPKL-KTW--------WHK----RKLKPARSQEVIDEPDTNSQI 634

  Fly   762 NQFTEDYNLLPAENNSLYVEYLEMVVQFGFITLFSLAFPLAPLLALLNNVIEVRLDAIKMLRFLR 826
            |.:..||.||..|  .|:.||||||:||||||:|..|.|||||.||:||.:||||||.|.:...|
Zfish   635 NPWENDYQLLVCE--GLFDEYLEMVLQFGFITIFVAACPLAPLFALINNWVEVRLDAQKFVCEYR 697

  Fly   827 RPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAFSTNLIPKIVYAASMGDPELNNYLNFTLAVFN 891
            |||..||:|||:|.:|:..::.:||.|:|.:|||:::.:|::.|..:.|  .::.|:||||:|..
Zfish   698 RPVVERAQDIGIWLTILQFISYLAVISNAFLIAFTSDFLPRLFYRYTAG--SMSGYINFTLSVAP 760

  Fly   892 TKDFQVQPLLGGSQHVNETVCRYTEFRN----SPEDPHPYKRPMIYWKILTGRLAFIVIYQNIIT 952
            ....|           ||..|||...|:    :.:|         |:.:|..||:|::|:::::.
Zfish   761 ANFTQ-----------NEMSCRYRGLRDEKGQNTQD---------YYHLLAIRLSFVIIFEHVVL 805

  Fly   953 MLQGILRWAVPDVSGRLLKRIKRENFLLREHIIEYEKQHAMKLVQTELNGQQKSEGELRQR---- 1013
            ::..|:.|.|||:...:..:||||:::.:|.:.  |.|...|.|..|: |:|..  |||||
Zfish   806 LIGRIIDWIVPDIPEEVEIKIKREHYMAKEALA--ENQSLSKSVLEEM-GRQNF--ELRQRIRTQ 865

  Fly  1014 --NNETVIRNRDEA 1025
              .|.....:.|||
Zfish   866 SPTNNMSPTSEDEA 879

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_727578.3	Anoct_dimer	183..392	CDD:465044	62/259 (24%)
		Anoctamin	395..976	CDD:461349	230/604 (38%)
ano7	XP_009289708.1	Anoct_dimer	42..274	CDD:465044	62/259 (24%)
		Anoctamin	277..829	CDD:461349	230/604 (38%)