DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10353 and ano3

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	XP_021326430.1	Gene:	ano3 / 553392	ZFINID:	ZDB-GENE-111031-3	Length:	1026	Species:	Danio rerio

Alignment Length:	995	Identity:	317/995 - (31%)
Similarity:	496/995 - (49%)	Gaps:	186/995 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 GGGGDHTDAAIAAQMIALQNGRNHLPTGIGVTGDGGQGGGDDEVSRRLLRTSSNISNKDKKLPIT 171
            ||....||..:..|...:..|:....|              |.|..:.|.|.|.:
Zfish   115 GGFEPKTDETLLVQQKPVSRGKLEART--------------DSVKGKNLETPSGL---------- 155

  Fly   172 YSQWKSRTYRRFDDGKRSVDFVLAY-NGETQLEEHRRKCEIFEANLQREGLQLEHNKV---QRVH 232
                      .|.|||:.:|::|.| ....|:|   ::| .||.||:.|||.||....   ..:.
Zfish   156 ----------MFRDGKKRIDYILVYKKSSPQVE---KRC-TFERNLRAEGLMLEKEPSLTNSDIM 206

  Fly   233 FIKIHAPAEVLYRYAEILKIKVPLKPIPGQDQIFAESAHEFKTCF--SRMCKSLFSSVQLNTALF 295
            |:|||||.:.|.:|||.:.|::|.:                |.|:  ....|::.|..||.....
Zfish   207 FVKIHAPWDTLCKYAEQMNIRMPFR----------------KKCYFTDWKKKAMGSRFQLRFRQL 255

  Fly   296 PEREPRIHLEFSRNYL-ELYDTE------------------HPNFLDASTRYSIINFILQRQRFV 341
            ....||..::..:..| :|.:|:                  ...|...|||..|::.:|||.::.
Zfish   256 KSWLPRNPMKLDKEALPDLVETDCYTAPFCRARMHHFTINNRETFFSNSTRSRIVHHVLQRTKYE 320

  Fly   342 EGEETAD------NL--------------------GIEKLVQDGVYTCAYTLHD----------- 369
            :|:....      ||                    ||.:|:.:..|..|:..|:
Zfish   321 DGKSKMAPPLCCLNLLYYYGQHERLLIGQSGSSWEGINRLLGNSTYEAAFPPHEGCYKSRHPIKT 385

  Fly   370 ---KDDRDRLLKEWANISKWKNLQPLDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGVLCFLYG 431
               ::.|..|.:.||....|...||||.|:.|||.|:.|||||||:||.||||.::.|:..||||
Zfish   386 HGAQNHRHLLYERWARWGIWYKYQPLDLIRRYFGEKIGLYFAWLGWYTGMLIPAALVGLFVFLYG 450

  Fly   432 FITWNSDPISRDICDDNGTIMCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSMAIWAVV 496
            ..|.:|..:|::||:.|.|:|||.|:.:|..|.|:::|..:|..:|.||..||.||..|||||.|
Zfish   451 LFTMDSSQVSKEICEANTTVMCPMCEGNCSSWTLSDSCVYAKVTHLFDNGGTVFFAIFMAIWATV 515

  Fly   497 YLEFWKRYSAGLVHRWGLTGFTHH---------VEHPRPQYLARISRTKK---LAGKAYEQDHTG 549
            :||||||..|.|.:.|.|..:...         .|..|||:.|:.||.::   ::||
Zfish   516 FLEFWKRRRAELTYDWDLIDWEEEECKPCVMVCSEELRPQFEAKYSRKERVNPISGK-------- 572

  Fly   550 KRTILDPDVPFWSFKFLPNFTSYSIMVLFICISVI--AIAGIIIYRMAQRASHSILGSENSMTFK 612
                  |: ||.......:....|:..:|..||::  |:..::::|        ::..|..::|:
Zfish   573 ------PE-PFQPLTDKLSRLMVSVSGIFFMISLVLTAVFAVVVFR--------LIAMEKFVSFQ 622

  Fly   613 VMILP-----MTAG---IIDLIVISLLDMVYSNLAVKLTNYEYCRTQTEYDESLTIKNYVFQFVN 669
            ...:.     .|:|   .|:.::|..|::||..:|..|||.|:.||::|::.|..:|.::|||||
Zfish   623 WEFVKKNWQFATSGTGVCINFMIIMSLNVVYEKVAYLLTNLEHPRTESEWENSFALKMFLFQFVN 687

  Fly   670 YYSSLFYIAFLKGKFVGYPAKYNRVLG-FRQEECNPGGCLMELCMQLVIIMAGKQAVNAIVEMLI 733
            ..||.|||||..|:|.|.|..||::.. :|.|||:|.|||::||:|:.:||..||..|..:|:..
Zfish   688 LNSSTFYIAFFLGRFAGRPGDYNKLFNRWRMEECHPSGCLIDLCLQMGVIMVLKQIWNNFMELGY 752

  Fly   734 PYLMRTFKELSYRHGWYKSHQDQRLVPYNQFTEDYNLLPAENNSLYVEYLEMVVQFGFITLFSLA 798
            |.|...:.....:....:|:..:.|   .|:..|:||.|...:.|..||||||:||||.|:|..|
Zfish   753 PLLQNWWSRRKMKRAGEQSNSKEEL---PQWDRDWNLQPMNAHGLVDEYLEMVLQFGFTTIFVAA 814

  Fly   799 FPLAPLLALLNNVIEVRLDAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAFSTN 863
            ||||||||||||:||:||||.|.:...|||:..||.|||:||.::..:..:||.::|.:||.:::
Zfish   815 FPLAPLLALLNNIIEIRLDAYKFVTQWRRPMPARATDIGIWHGVLEGIGVVAVITNAFVIAITSD 879

  Fly   864 LIPKIVYAASMG---------DPELNNYLNFTLAVFNTKDFQVQPLLGGSQHVNETVCRYTEFRN 919
            .||:.|||...|         :..|..|||.:|:||:..:     |..|| :.|: .|||.::|.
Zfish   880 YIPRFVYAIKYGPCVDKGYRHEKCLRGYLNNSLSVFDMGE-----LRNGS-YENQ-YCRYRDYRA 937

  Fly   920 SPEDPHPYKRPMIYWKILTGRLAFIVIYQNIITMLQGILRWAVPDVSGRLLKRIKRENFLLREHI 984
            .|..|.||:..:.:|.:|..|||||:::::::..::..:...:||:...|..|::||.:|::|.:
Zfish   938 PPWSPEPYEFTLQFWHVLAARLAFIIVFEHLVFGIKTFIAHMIPDMPKDLCDRMRREKYLMQEMV 1002

  Fly   985 IEYEKQHAMKLVQTELNGQQ 1004
            .|.|.:|..|  :.:.||::
Zfish  1003 YEAELEHLQK--ERKKNGKR 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	65/273 (24%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	228/613 (37%)
ano3	XP_021326430.1	Anoct_dimer	163..411	CDD:318420	61/267 (23%)
ano3	XP_021326430.1	Anoctamin	414..994	CDD:309610	227/612 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	1	1.000	-	-		mtm6575
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.820