Protein Alignment CG10353 and ANO7

DIOPT Version :10

• Sequence 1: NP_727578.3
• Gene: CG10353 / 32148
• FlyBaseID: FBgn0030349
• Length: 1029
• Species: Drosophila melanogaster
• Sequence 2: XP_047300552.1
• Gene: ANO7 / 50636
• HGNCID: 31677
• Length: 928
• Species: Homo sapiens
• Alignment Length: 877
• Identity: 293/877 - (33%)
• Similarity: 447/877 - (50%)
• Gaps: 136/877 - (15%)

  Fly   188 RSVDFVLAYNGETQLEE------------HRRKCEIFEANLQREGLQLEH----------NKVQR 230
            |..||||.:..:.:|:.            ||...|.|..||:..||.::.          .:..|
Human    69 RIADFVLVWEEDLKLDRQQDSAARDRTDMHRTWRETFLDNLRAAGLCVDQALTEPWVPTAGRPGR 133

  Fly   231 VHFIKIHAPAEVLYRYAEILKIKVPLKPIPGQDQIFAE--------SAHEFKT---CFSRMCKSL 284
            .|...:..|..:|.....:.:...|...:.|..|...:        :.|..:.   |..|..:.|
Human   134 EHHSALRPPQRLLGCALLLRRRPAPEAALAGVTQPGLQLVGRPAGMAGHPQRPAGGCARRTPRVL 198

  Fly   285 FSSVQL-NTALFPEREPRIHLEFSRNYL--ELYDTEHPNFLDASTRYSIINFILQRQRFVEGEET 346
            ...||. ..|..|..  .:|...:.::|  :..||    |..::.|:.|:..||.:..:  |.|.
Human   199 LLPVQSEQAATLPPN--LLHCSHAHSFLGSDNQDT----FFTSTKRHQILFEILAKTPY--GHEK 255

  Fly   347 ADNLGIEKLVQDGVYTCAYTLHD--------------KDDRDRLLKEWANISKWKNLQPLDQIKD 397
            .:.|||.:|:.:||.:.|:.|||              .:.|..|.:.||...||...||||.::.
Human   256 KNLLGIHQLLAEGVLSAAFPLHDGPFKTPPEGPQAPRLNQRQVLFQHWARWGKWNKYQPLDHVRR 320

  Fly   398 YFGAKVALYFAWLGFYTQMLIPISVFGVLCFLYGFITWNSDPISRDICDDNGTI-MCPQCDRSCD 461
            |||.|||||||||||||..|:|.:|.|.|.||.|.....||..::::|....:. |||.| ..|.
Human   321 YFGEKVALYFAWLGFYTGWLLPAAVVGTLVFLVGCFLVFSDIPTQELCGSKDSFEMCPLC-LDCP 384

  Fly   462 YWRLNETCTSSKF----NYLIDNNMTVVFAFSMAIWAVVYLEFWKRYSAGLVHRWGLTGFTHHVE 522
            :|.|:..|..::.    ..|.|:..||.|:..||:|||:.||:|||.||.|.:||..:.:....|
Human   385 FWLLSSACALAQVREEAGRLFDHGGTVFFSLFMALWAVLLLEYWKRKSATLAYRWDCSDYEDTEE 449

  Fly   523 HPRPQYLARISRT--KKLAG--KAYEQDHTGKRTILDPDVPFWSFKFLPNFTSYSIMVLFICISV 583
            .||||:.|....|  ..:.|  :.|..:.:..|.:|...|               ::|:.:.:.|
Human   450 RPRPQFAASAPMTAPNPITGEDEPYFPERSRARRMLAGSV---------------VIVVMVAVVV 499

  Fly   584 IAIAGIIIYR-----MAQRASHSILGSENSMTFKVMILPMTAGIIDLIVISLLDMVYSNLAVKLT 643
            :.:..||:||     :..|:.:::|.:..|     .|..:|..:::|:.|.:|..:|.:||..||
Human   500 MCLVSIILYRAIMAIVVSRSGNTLLAAWAS-----RIASLTGSVVNLVFILILSKIYVSLAHVLT 559

  Fly   644 NYEYCRTQTEYDESLTIKNYVFQFVNYYSSLFYIAFLKGKFVGYPAKYNRVLGFRQEECNPGGCL 708
            .:|..||||:::::.|:|.::|||||:|||..||||.||:|||||..|:.:.|.|.|||..||||
Human   560 RWEMHRTQTKFEDAFTLKVFIFQFVNFYSSPVYIAFFKGRFVGYPGNYHTLFGVRNEECAAGGCL 624

  Fly   709 MELCMQLVIIMAGKQAVNAIVEMLIPYLMRTFKELSYRHGWYKSHQDQRL------------VPY 761
            :||..:|::||.|||.:|.:.|:|||.|          .||:   |..||            ...
Human   625 IELAQELLVIMVGKQVINNMQEVLIPKL----------KGWW---QKFRLRSKKRKAGASAGASQ 676

  Fly   762 NQFTEDYNLLPAENNSLYVEYLEMVVQFGFITLFSLAFPLAPLLALLNNVIEVRLDAIKMLRFLR 826
            ..:.:||.|:|.|  .|:.||||||:||||:|:|..|.|||||.|||||.:|:||||.|.:...|
Human   677 GPWEDDYELVPCE--GLFDEYLEMVLQFGFVTIFVAACPLAPLFALLNNWVEIRLDARKFVCEYR 739

  Fly   827 RPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAFSTNLIPKIVYAASMGDPELNNYLNFTLAVFN 891
            |||..||:|||:|..|:..:|.:||.|:|.::|||::.:|:..|..:... :|..:||||||
Human   740 RPVAERAQDIGIWFHILAGLTHLAVISNAFLLAFSSDFLPRAYYRWTRAH-DLRGFLNFTLA--- 800

  Fly   892 TKDFQVQPLLGGSQHVNETVCRYTEFRNSPEDPHPYKRPMIYWKILTGRLAFIVIYQNIITMLQG 956
                 ..|....:.| |.| |||..||:  :|.| |.:  .||.:|..||||::::::::..:..
Human   801 -----RAPSSFAAAH-NRT-CRYRAFRD--DDGH-YSQ--TYWNLLAIRLAFVIVFEHVVFSVGR 853

  Fly   957 ILRWAVPDVSGRLLKRIKRENFLLREHIIEYE 988
            :|...|||:...:..::|||.:|.::.:.|.|
Human   854 LLDLLVPDIPESVEIKVKREYYLAKQALAENE 885

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_727578.3	Anoct_dimer	183..392	CDD:465044	57/253 (23%)
		Anoctamin	395..976	CDD:461349	228/606 (38%)
ANO7	XP_047300552.1	Anoct_dimer	67..315	CDD:465044	57/253 (23%)
		Anoctamin	318..873	CDD:461349	228/606 (38%)