DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10353 and ano1a

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	XP_009301746.1	Gene:	ano1a / 407698	ZFINID:	ZDB-GENE-121127-3	Length:	966	Species:	Danio rerio

Alignment Length:	999	Identity:	334/999 - (33%)
Similarity:	516/999 - (51%)	Gaps:	126/999 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 STALEHLNGGGGG----GGDHTDAAIAAQMIALQNGR-NHLPTGI-GVTGDGGQGGGDDEVSRRL 154
            :||.:.....|.|    |.:.|:...:.|....:|.: ..:|..: |:..|..:|..|.......
Zfish     8 NTARKDDEADGSGEKLLGFNSTEEQPSGQESMWRNEKYESVPLDVKGIDEDNSKGTRDSLYPHTT 72

  Fly   155 LRTSSNISNKDKKLPITYSQWKSRTYRRFDDGKRSVDFVLAYN---------------------- 197
            |..|.....|.|         ..:.:..|.||.|.:|:||.|:
Zfish    73 LLKSQQADEKPK---------DPKLWPYFKDGHRRIDYVLTYHIQKPQNTGKQSSKSCLGGCLCC 128

  Fly   198 ---GET--------------QLEEH----RRKCEIFEANLQREGLQLEH---NKVQRVHFIKIHA 238
               |:|              :|:.|    |.:.|.||.||:..||::|.   ||:..|.|:||||
Zfish   129 KKRGQTNPPVPDPELASQEQRLDYHDDDQRLRREEFEENLREMGLEMEKEEGNKIPGVGFLKIHA 193

  Fly   239 PAEVLYRYAEILKIKVPL--KPIPGQDQIFAESAHEFKTCFSRMCKSLFSSVQLNTALFPEREPR 301
            |.|||.|.||.:|:|:|.  |..........|.|..|...|:...:......|:      |.|..
Zfish   194 PWEVLCREAEFMKLKMPTIKKYEVSHGNSIVEKASRFMQKFTAPLQPKVGDRQI------EHEKH 252

  Fly   302 IHLEFSRNYLELYD-TEHPNFLDASTRYSIINFILQRQRFVEGEETADNLGIEKLVQDGVYTCAY 365
            :...|||....|:| ::..:|.|:.||.||:..||:|.:....:..   :||..|:.:|:||.||
Zfish   253 LSYPFSREKQHLFDLSDRNSFFDSKTRSSIVYEILKRTKCTRAKYI---MGIISLLGNGIYTSAY 314

  Fly   366 TLHDKD---------DRDRLLKEWANISKWKNLQPLDQIKDYFGAKVALYFAWLGFYTQMLIPIS 421
            .|||.|         ||..|.:|||:.|.:...||:..|:.|||.||.|||||||.|||||||.:
Zfish   315 PLHDGDIDDVHAEINDRKILYEEWASYSIFYKYQPIGLIRKYFGEKVGLYFAWLGVYTQMLIPAA 379

  Fly   422 VFGVLCFLYGFITWNSDPISRDICDD-NGTIMCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTVV 485
            :.||:.||||..|.:.:..|.:|||: |...|||.|||:|.||:|...|.:::.::|.||..||.
Zfish   380 IVGVIVFLYGCATVDDNIPSMEICDERNNITMCPMCDRACSYWKLVTACGTARASHLFDNAATVF 444

  Fly   486 FAFSMAIWAVVYLEFWKRYSAGLVHRWGLTGFT----HHVEHPRPQYLARISRTKKLAGKAYEQD 546
            ||..||:||.:::|.|||....|.:.|.||||.    ....|||.:|...:.: |.|..:...:.
Zfish   445 FAIFMALWAAMFMEHWKRRQVRLNYLWDLTGFEDTEGKQKSHPRAEYEFHVMK-KSLRKEKSPKA 508

  Fly   547 HTGKRTILDPDVPFWSFKFLPNFTSYSI-MVLFICISVIAIAGIIIYRMAQRASHSILGSENSMT 610
            ...|.|..|.         :|.:.:..| |:..||:::..:.|:::||::...:   |...::.|
Zfish   509 GNVKLTCTDR---------MPAYMTIIITMIFLICVTLAIVFGVVLYRVSIMTA---LHMSSTPT 561

  Fly   611 FKVMI---LPMTAGIIDLIVISLLDMVYSNLAVKLTNYEYCRTQTEYDESLTIKNYVFQFVNYYS 672
            |:..|   :..|..||:||:|.::|.||..:|..||..|..:|...::|.|..|.:|.:|.|.::
Zfish   562 FRSNIRATVKTTGAIINLIIIIIMDEVYGAVARWLTIMEVPKTDKSFEERLIFKTFVLKFANAFT 626

  Fly   673 SLFYIAFLKGKFVGYPAKYNRVLG-FRQEECNPGGCLMELCMQLVIIMAGKQAV-NAIVEMLIPY 735
            .:.|:||.:|:.:|.|.||..|:| :|.|||...|||||||:||.|.|.|||.: |.:.|:.:|.
Zfish   627 PIVYLAFFRGRLIGRPGKYIYVMGSYRMEECAHAGCLMELCIQLCITMLGKQLIQNNLFEIGVPK 691

  Fly   736 LMRTFKELSYRHGWYKSHQDQRLVPYNQFTEDYNLLPAENNSLYVEYLEMVVQFGFITLFSLAFP 800
            :    |:|..:......||::.....::..:|:.|.|..  .|..||:||::|||.:|||..:||
Zfish   692 I----KKLLRQRKIDPKHQEELNKTLHRHEKDHFLGPFV--GLNPEYMEMIIQFGMVTLFVASFP 750

  Fly   801 LAPLLALLNNVIEVRLDAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAFSTNLI 865
            ||||.|||||:||:||||.|.:..||||:.:||:|||:|::::..::::||..:|.:|:|:::.|
Zfish   751 LAPLFALLNNIIEIRLDAKKFVTELRRPIAVRAKDIGIWYTLLRGLSKVAVIVNAFVISFTSDFI 815

  Fly   866 PKIVYAASMG-DPELNNYLNFTLAVFNTKDFQ--VQPLLGGSQHVNETV--CRYTEFRNSPEDPH 925
            |::||..... |..|:.::|.||:.||...||  .:||  ...|:...|  |||.::|:.|....
Zfish   816 PRLVYQYMYSPDGTLHGFVNHTLSYFNVTHFQPGTEPL--EPMHLGYQVDTCRYKDYRDPPWSDT 878

  Fly   926 PYKRPMIYWKILTGRLAFIVIYQNIITMLQGILRWAVPDVSGRLLKRIKRENFLLREHIIE-YEK 989
            ||:....:|.||..|.||::::||::.::...:.|.:||:...:..:|.:|    |..||| :.|
Zfish   879 PYEFSREFWAILAARFAFVILFQNVVMLMSDFVDWLIPDIPKDISLKIHKE----RNLIIELFMK 939

  Fly   990 QHAMKLVQTELNGQQKSEGELRQR 1013
            :...|..:..:|  ..|...||.|
Zfish   940 REQGKKYRNTMN--DPSPQPLRSR 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	81/266 (30%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	223/597 (37%)
ano1a	XP_009301746.1	Anoct_dimer	91..350	CDD:292796	81/267 (30%)
ano1a	XP_009301746.1	Anoctamin	353..930	CDD:282414	224/601 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	1	1.000	-	-		mtm6575
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.920