DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10353 and CG6938

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	NP_001261733.1	Gene:	CG6938 / 39362	FlyBaseID:	FBgn0036235	Length:	1245	Species:	Drosophila melanogaster

Alignment Length:	1068	Identity:	340/1068 - (31%)
Similarity:	537/1068 - (50%)	Gaps:	208/1068 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VRTNDYDYPESEMDERESLYFDTISLAESEAAAAAAAHRKSISQSRNTIYHSAVDLAGDEGGGGS 69
            |..||.|.|.:.|  |.||   .::|:.:..:|........:.:|.    ||.|
  Fly   232 VGNNDEDIPGTAM--RRSL---GLNLSPTLGSADRVNQSYEVMESS----HSNV----------- 276

  Fly    70 GGGRLRLGGGAAAEHAALAWQPGYRQ--STALEHLNGGGGGGGDHTDAAIAAQMIALQNGRNHLP 132
                             |..|.||||  .|..:..:......|.:..:..|::..:|
  Fly   277 -----------------LPDQFGYRQLIPTERKASDTASSVSGSYYGSRKASKSNSL-------- 316

  Fly   133 TGIGVTGDGGQGGGDDEVSRRLLRTSSNISNKDKKLPITYSQWKSRTYRRFDDGKRSVDFVLAYN 197
                    ||:.|.:..||::         :::...|      :|..:|   ||:|.||.|||:.
  Fly   317 --------GGESGDERRVSKQ---------DREGLDP------ESLMFR---DGRRKVDMVLAWE 355

  Fly   198 GE-----TQLEEHRR-KCEIFEANLQREGLQLE-HNKVQ----RVHFIKIHAPAEVLYRYAEILK 251
            .|     |:.|..|| ....|..||.:|||::| .:|.|    :..|:|||.|..:..|.||::.
  Fly   356 EEDLGVMTEAEAKRRDNRRSFMENLIKEGLEVELEDKSQSFNEKTFFLKIHLPWRLETRLAEVMN 420

  Fly   252 IKVP--------LKPIPGQDQIFAESAHEFKTCFSRMCKSLFSSVQLNTALFPEREPRIHLEFSR 308
            :|:|        :||...::.:...:...:|..:.|:.|    .:||:..|         ||...
  Fly   421 LKLPVKRFITISVKPSWDEENVVLRNMQYWKDVWQRLTK----KIQLDQTL---------LEGET 472

  Fly   309 NYLELYDTEHP--NFL--DASTRYS------IINFILQRQRFVEGEETADNLGIEKLVQDGVYTC 363
            .:.......:|  .|:  |.:|.::      ::..:|.|..|.|    :|..||.:|:.||.|..
  Fly   473 TFKAATANGNPEEQFIVKDRATAFTSAQRSLMVMQVLIRTPFDE----SDRSGIRRLMNDGTYLG 533

  Fly   364 AYTLHD-----------KDDRDRLLKEWANISKWKNLQPLDQIKDYFGAKVALYFAWLGFYTQML 417
            .:.||:           ..||..|.:.||:.|:|...|||..::.|||.|:||||.||||||:||
  Fly   534 CFPLHEGRYDRPHSSGISLDRRVLYQTWAHPSQWYKKQPLCLVRKYFGDKIALYFCWLGFYTEML 598

  Fly   418 IPISVFGVLCFLYGFITWNSD---PISRDICDDNGT---IMCPQCDRSCDYWRLNETCTSSKFNY 476
            :..:|.|.|||:||..|..|:   | |::||::.||   .:||.||::|.|.||:|:|..|:..|
  Fly   599 VYPAVVGTLCFIYGLATLESEDNTP-SKEICNEYGTGNITLCPLCDKACSYQRLSESCLFSRLTY 662

  Fly   477 LIDNNMTVVFAFSMAIWAVVYLEFWKRYSAGLVHRWGLTGFTHHV---EHPRPQY--------LA 530
            |.||..||.||..|:.||..:||.|||..:.||..|.|    |:|   |..||::        :.
  Fly   663 LFDNPSTVFFAIFMSFWATTFLELWKRKQSVLVWEWDL----HNVDMDEENRPEFETNATTFRMN 723

  Fly   531 RISRTKKLAGKAYEQDHTGKRTILDPDVPFW--SFKFLPNFTSYSIMVLFICISVIAIAGIIIYR 593
            .::|.|                  :|.:..|  |.:|:   .:.|.::..|.:.:.|:.|.|:||
  Fly   724 PVTREK------------------EPYMSTWNRSIRFV---ITGSAVLFMISVVLSAVLGTILYR 767

  Fly   594 MAQRASHSILG------SENSMTFKVMILPMTAGIIDLIVISLLDMVYSNLAVKLTNYEYCRTQT 652
            :.  ....|.|      .|::..|    ..:||.:|:|:||.:|..:|..:|:||||.|..||.|
  Fly   768 IT--LVSVIYGGGGFFVKEHAKLF----TSVTAALINLVVIMILTRIYHRMAIKLTNLENPRTHT 826

  Fly   653 EYDESLTIKNYVFQFVNYYSSLFYIAFLKGKFVGYP----AKYNRVLGFRQEECNPGGCLMELCM 713
            ||::|.|.|.:.|:|:|:||||.||||.||:|..||    |:.:.....:.:.|:|.|||.|||:
  Fly   827 EYEDSYTFKIFFFEFMNFYSSLIYIAFFKGRFFDYPGDDQARKSEFFRLKNDICDPAGCLSELCI 891

  Fly   714 QLVIIMAGKQAVNAIVEMLIPYLMRTFKELSYRHGWYKSHQDQRLVPYNQFTEDYNLLPAENNSL 778
            ||.|||.|||..|..:|.|.|.....:::..::    ::.:|:..: :..:.:||::......:|
  Fly   892 QLAIIMVGKQCWNNFMEYLFPKFWNWWRQRKHK----QATKDESHL-HMAWEQDYHMQDPGRLAL 951

  Fly   779 YVEYLEMVVQFGFITLFSLAFPLAPLLALLNNVIEVRLDAIKMLRFLRRPVGMRARDIGVWHSIM 843
            :.|||||::|:||:|||..|||||||.||||||.|:||||.||:...|||:..|..|||.|:.|:
  Fly   952 FDEYLEMILQYGFVTLFVAAFPLAPLFALLNNVAEIRLDAYKMVTQARRPLAERVEDIGAWYGIL 1016

  Fly   844 TVVTRIAVASSAMIIAFSTNLIPKIVYAASMGDPE-LNNYLNFTLAVFNTKDFQVQPLLGGSQHV 907
            .::|..||.|:|.:||::::.||::||.....:.. |..|:..:|::|||.|::.:  .|.|  |
  Fly  1017 RIITYTAVVSNAFVIAYTSDFIPRMVYKFVYSETHTLAGYIEHSLSIFNTSDYKEE--WGAS--V 1077

  Fly   908 NE---TVCRYTEFRNSPEDPHPYKRPMIYWKILTGRLAFIVIYQNIITMLQGILRWAVPDVSGRL 969
            :|   ..|:|..:||.|:|..||.....||.:...||||:|::::::.::.||:::.:|||...:
  Fly  1078 SEKDPDTCQYRGYRNGPKDYEPYGLSPHYWHVFAARLAFVVVFEHVVFVITGIMQFIIPDVPSEV 1142

  Fly   970 LKRIKRENFLLREHIIEYEKQHAMKLVQ 997
            ..:::||..|.:|  .:|  ||.:|..|
  Fly  1143 KTQMQREQLLAKE--AKY--QHGIKRAQ 1166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	67/248 (27%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	230/614 (37%)
CG6938	NP_001261733.1	Anoct_dimer	340..573	CDD:292796	68/252 (27%)
CG6938	NP_001261733.1	Anoctamin	576..1150	CDD:282414	230/614 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	122	1.000	Domainoid score	I1430
eggNOG	1	0.900	-	-		E1_KOG2514
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	251	1.000	Inparanoid score	I1994
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	1	1.000	-	-		otm43787
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	P	PTHR12308
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	1	1.000	-	-		X144
	11	10.900