DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10353 and Ano7

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	NP_001004071.1	Gene:	Ano7 / 367318	RGDID:	1302987	Length:	860	Species:	Rattus norvegicus

Alignment Length:	864	Identity:	301/864 - (34%)
Similarity:	465/864 - (53%)	Gaps:	109/864 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   190 VDFVLAYNGETQLEE---------HRRKCEIFEANLQREGLQLEHNKVQ----RVHFIKIHAPAE 241
            :||||.:..:.:..|         |....|.|..||:..||:::...||    .||:|.:.||..
  Rat    55 IDFVLVWEEDLRSRENPTQDKTDTHEIWRETFLENLRVAGLKIDQRDVQDEAAAVHYILLSAPWA 119

  Fly   242 VLYRYAEILKIKVPLKPIPGQDQIFAESAHEFKTCFSRMCKSLFSSVQLNTALFPEREPRIH-LE 305
            ||..|||.|::|:||:.:|.|...::.:..|:....:.:.:::           |:..|..: .:
  Rat   120 VLCYYAEDLRLKLPLQELPNQASNWSATLLEWLGIPNILLENV-----------PDTPPEYYSCQ 173

  Fly   306 FSRNYLE--LYDTEHPNFLDASTRYSIINFILQRQRFVEGEETADNLGIEKLVQDGVYTCAYTLH 368
            |..:.|:  |.......|..::.|:.|:..||.:..:  |.:.....||::|:.:||::.|:.||
  Rat   174 FKASKLQWFLGSDNQDTFFTSTKRHQILFEILAKTPY--GHQKKGLFGIDQLLAEGVFSAAFPLH 236

  Fly   369 D--------------KDDRDRLLKEWANISKWKNLQPLDQIKDYFGAKVALYFAWLGFYTQMLIP 419
            |              ...|..|.|.||...||:..||||.::.|||.|||||||||||||..|:|
  Rat   237 DGPFSVVPESSQVLGLTQRQVLFKHWARWGKWRKYQPLDHVRRYFGEKVALYFAWLGFYTGWLLP 301

  Fly   420 ISVFGVLCFLYGFITWNSDPISRDICDDNGTI-MCPQCDRSCDYWRLNETCTSSKFNYLIDNNMT 483
            .:|.|.:.||.|.....||..::::|..:.|. |||.|. .|.:|.|:..||.::...|.|:..|
  Rat   302 AAVVGTVVFLAGCFLVFSDVPTQELCHSSDTFDMCPLCS-DCSFWLLSSACTLAQAGRLFDHGGT 365

  Fly   484 VVFAFSMAIWAVVYLEFWKRYSAGLVHRWGLTGFTHHVEHPRPQYLARISRTKKLAGKAYEQDHT 548
            |.|:..||:|||:.||:|||.:|.|.:||..:.:....|.||||:.|                 |
  Rat   366 VFFSLFMALWAVLLLEYWKRKNATLAYRWDCSDYEDIEERPRPQFAA-----------------T 413

  Fly   549 GKRTILDP----DVPFWSFKFLPN-----FTSYSIMVLFICISVIAIAGIIIYRMAQRASHSILG 604
            ...|.|:|    |.|::..|   |     .....::::.:.:.::.:..||:|    ||..:|:.
  Rat   414 APMTALNPITGEDEPYFPEK---NRVRRMLAGSVVLLMMVAVVIMCLVSIILY----RAVMAIIV 471

  Fly   605 SENSMTF----KVMILPMTAGIIDLIVISLLDMVYSNLAVKLTNYEYCRTQTEYDESLTIKNYVF 665
            |:::..|    ...|..:|..:::|:.|.:|..||..||..||.:|..||||.::::.|:|.::|
  Rat   472 SKSNNAFLSAWASRIASLTGSVVNLVFILILSKVYVILAQVLTRWEMHRTQTAFEDAFTLKVFIF 536

  Fly   666 QFVNYYSSLFYIAFLKGKFVGYPAKYNRVLGFRQEECNPGGCLMELCMQLVIIMAGKQAVNAIVE 730
            ||||:|:|..||||.||:|||||..|:.:.|.|.|||..||||.||..:|::||.|||.:|.:.|
  Rat   537 QFVNFYASPVYIAFFKGRFVGYPGNYHTLFGVRNEECPAGGCLSELAQELLVIMVGKQIINNVQE 601

  Fly   731 MLIPYLMRTFKELSYRHGWYKSHQDQRLVPYNQFTEDYNLLPAENNSLYVEYLEMVVQFGFITLF 795
            :|:|.|...:::|..|.  .|:.......|:.   .||.|||.|  .|:.||||||:||||:|:|
  Rat   602 VLVPKLKGCWQKLCSRR--KKAGMGANPAPWE---ADYELLPCE--GLFHEYLEMVLQFGFVTIF 659

  Fly   796 SLAFPLAPLLALLNNVIEVRLDAIKMLRFLRRPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAF 860
            ..|.|||||.|||||.:|:||||.|.:...||||..||:|||:|..|:..:|.:||.|:|.::||
  Rat   660 VAACPLAPLFALLNNWVEIRLDARKFVCEYRRPVAERAQDIGIWFHILAGLTHLAVISNAFLLAF 724

  Fly   861 STNLIPKIVYAASMGDPELNNYLNFTLAVFNTKDFQVQPLLGGSQHVNETVCRYTEFRNSPEDPH 925
            |::.:|::.|:.:.. |:|..:||||||       :..|.. .|.| |.| |||..||:  :|.|
  Rat   725 SSDFLPRVYYSWTRA-PDLRGFLNFTLA-------RAPPTF-TSAH-NRT-CRYRAFRD--DDGH 776

  Fly   926 PYKRPMIYWKILTGRLAFIVIYQNIITMLQGILRWAVPDVSGRLLKRIKRENFLLREHIIEYEKQ 990
             |.  ..||.:|..||||::::::::......|...|||:...:..::|||.:|.::.:.:.|
  Rat   777 -YS--PTYWTLLAIRLAFVIVFEHVVFSTGRFLDLLVPDIPESVEIKVKREYYLAKQALADNE-- 836

  Fly   991 HAMKLVQTELNGQQKSEGE 1009
              ..|..|.:.|:|....|
  Rat   837 --ALLGATGVKGEQPPSSE 853

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	59/231 (26%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	231/595 (39%)
Ano7	NP_001004071.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..50
		Anoct_dimer	54..274	CDD:292796	59/231 (26%)
		Anoctamin	277..824	CDD:282414	230/594 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100405
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820