DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10353 and CG15270

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	NP_609738.1	Gene:	CG15270 / 34886	FlyBaseID:	FBgn0028879	Length:	1338	Species:	Drosophila melanogaster

Alignment Length:	932	Identity:	228/932 - (24%)
Similarity:	352/932 - (37%)	Gaps:	290/932 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   136 GVTGDGGQGGGDDEVSRRLLRTSSNISNKDKKLPITYSQWKSRTYRRFDDGKRSVDFVLAYNGET 200
            |..|.|.:.||:|:.      |..|  |.:..|.....:..|......::..|.:...:.|.|..
  Fly    37 GELGGGPRDGGEDDF------TDDN--NFESNLRRRKGKIISCAKETIENASRQLRRKVPYAGHL 93

  Fly   201 Q------LEEHRRKCEI---FEANLQREGL-------------------QLEHNKVQRVHFIKIH 237
            .      |.:...:|::   |..:...|.|                   |::.::..|.:...:.
  Fly    94 MTPRRLWLNKIPTQCDVVIEFPEDAPDEALRWLLARIRSQPPAGLGLLVQVKAHESTRRNAFYVS 158

  Fly   238 APAEVLYRYAEILKIKVPLKPIPGQDQIFAESAHEFKT----CFSRMCKSLFSSVQLNTALFPER 298
            ||..||::.||..::...|:|..|      .:..||.|    ||.::...:.|     ||||..:
  Fly   159 APVNVLFKAAEEARLPKRLRPDLG------GALREFTTRESHCFQQLRGDVGS-----TALFTSQ 212

  Fly   299 EPRIHLEFSRNYLELYDTEHPNFLDASTRYSIINFILQRQRFVEGEETADNLGIEKLVQDGVYTC 363
            |        |.:|.|...:.   |.|..  |.|..:..|....||:..     :....:.|:.|.
  Fly   213 E--------RQWLVLQVLQG---LRAGC--SDIEALHGRAAVAEGQSI-----VATWQESGLITQ 259

  Fly   364 AYTLHDKDDRDRLLKEWANISKWKNL---QPLDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGV 425
            .:.||:.....:|...|.     |.:   ||||.|..|||.||||||||||.||..|...:|||.
  Fly   260 VFPLHEPSSLTQLQTHWV-----KQIFAPQPLDDIAAYFGVKVALYFAWLGHYTCALGVPAVFGT 319

  Fly   426 LCFLYGFITWNSDPISRDICDDNGTIMCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSM 490
            :.:.   |.|.....::|:..                                     |:|:...
  Fly   320 ILYC---ILWGKGQTAQDMGH-------------------------------------VLFSLFN 344

  Fly   491 AIWAVVYLEFWKRYSAGLVHRWG-LTGFTHHVEHPRPQYLARISRTKKLAGKAYEQDHTGKRTIL 554
            ..||.:|||.|||||..|..||| |:.....:|.|||.|          .|...|.:.||:   |
  Fly   345 VAWASLYLEAWKRYSVELAFRWGTLSTPPELLEPPRPLY----------KGPLEENNVTGR---L 396

  Fly   555 DP-DVPFW---SFKFLPNFTSYSIMVLFICISVIAIAGIIIYRMAQRASHSILGSENSMTFKVMI 615
            :| :.|.|   :|::|.:|.     ::..|:.|:.....::.|........:  .|.|:...:.:
  Fly   397 EPKEAPAWQRRAFRYLVSFP-----IIGCCLCVVFAVMFLMLRFQDWWDSKL--PEESVLCCLSV 454

  Fly   616 LP--MTAGIIDLIVISLLDMVYSNLAVKLTNYEYCRTQTEYDESLTIKNYVFQFVNYYSSLFYIA 678
            :|  :.||     .|:|:|..|..|||.|.:.|..|.|::|:..|..|..:|||||.:.||||||
  Fly   455 IPKVLLAG-----AITLMDEAYFKLAVWLNDRENYRLQSKYENHLIAKVALFQFVNSFLSLFYIA 514

  Fly   679 FLKGKFVGYPAKYNRVLGFRQEECNPGGCLMELCMQLVIIMAGKQAVNAIVEMLIPYLMRTFK-- 741
            |.                .|.||        :|..||..::..:|.:..:.|..|||.:..:|
  Fly   515 FY----------------LRDEE--------KLKEQLAGLLISRQIIGNLRESAIPYFLEQWKLA 555

  Fly   742 ELSYRHGW--------------------------------YKSHQDQRLVPYNQFTEDYNLLPAE 774
            :||: :.|                                .||.|.:.       :...|:..||
  Fly   556 KLSF-NMWGALSPTQNVTRSLAEELATAEAELKAESTGTPTKSQQPES-------SSKRNIGQAE 612

  Fly   775 -NNSLY------VEYLEMVVQFGFITLFSLAFPLAPLLALLNNVIEVRLDAIKMLRFLRRPVGMR 832
             .:|||      .::|||:||.|::.|||.|||||.:.||:||::|:|.||.|:....:||.|.|
  Fly   613 IESSLYKYDGTFSDHLEMLVQMGYVVLFSAAFPLAGVCALINNLMEIRSDAFKLAHVHQRPFGQR 677

  Fly   833 ARDIGVWHSIMTVVTRIAVASSAMIIAFSTNLIPKIVYAASMGDPELNNYLNFTLAVFNTKDFQV 897
            ..:||.|.:.:::::..||..:..:|..|.                                 ||
  Fly   678 VANIGTWQNALSILSLAAVIVNCALIGLSG---------------------------------QV 709

  Fly   898 QPLLGGSQHVNETVCRYTEFRNSPEDPHPYKRPMIYWKILT--GRLAFIVIYQNIITMLQGILRW 960
            ..|                                 |..||  ..:..||..::|:..|:..|.|
  Fly   710 SRL---------------------------------WPGLTTAQTIILIVTLEHIMLGLRQALTW 741

  Fly   961 AVPDVSGRLLKRIKRENFLLRE 982
            .:|::...|...|.|.....||
  Fly   742 LLPELPSWLAAEIARAEHCRRE 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	48/243 (20%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	164/631 (26%)
CG15270	NP_609738.1	Anoctamin	289..758	CDD:282414	164/631 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I2829
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12308
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1964
SonicParanoid	0	0.000	Not matched by this tool.
	5	5.050