DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10353 and ANO9

DIOPT Version :9

Sequence 1:	NP_001245633.1	Gene:	CG10353 / 32148	FlyBaseID:	FBgn0030349	Length:	1029	Species:	Drosophila melanogaster
Sequence 2:	NP_001012302.2	Gene:	ANO9 / 338440	HGNCID:	20679	Length:	782	Species:	Homo sapiens

Alignment Length:	843	Identity:	266/843 - (31%)
Similarity:	429/843 - (50%)	Gaps:	146/843 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 DFVLAYNGETQLEEHRRKCEIFEANLQREGLQLEHNKVQRVHFIKIHAPAEV--LYRYAEILKIK 253
            |:||.....||.:..:.:.:.|...|:|:|..::..:.|:..|..|.|...|  |||
Human    35 DYVLVAQRHTQRDPRQARQQQFLEELRRKGFHIKVIRDQKQVFFGIRADNSVFGLYR-------- 91

  Fly   254 VPLKPIPGQDQIFAESAHEFKTCFSRMCKSLFSSVQLNTALFPEREPRIHLEFSRNYLELYDTEH 318
                                                  |.|.....|..|.|.:.      .|..
Human    92 --------------------------------------TLLLEPEGPAPHAELAA------PTTI 112

  Fly   319 PNFLDASTRYSIINFILQRQRFVEGEETADNLGIEKLVQDGVYTCAYTLHDKDDRDRLLKEWANI 383
            |  :..|.|..|:||::...:...||.      .|.|::|||:...:.||..:  .||.|.||
Human   113 P--VTTSLRIRIVNFVVMNNKTSAGET------FEDLMKDGVFEARFPLHKGE--GRLKKTWA-- 165

  Fly   384 SKWKNL---QPLDQIKDYFGAKVALYFAWLGFYTQMLIPISVFGVLCFLYGFITWNSDPISRDIC 445
             :|:::   ||:|:|::|||.||||||.|||:||.||:|.::.|:|.||.||..:.:..||::||
Human   166 -RWRHMFREQPVDEIRNYFGEKVALYFVWLGWYTYMLVPAALTGLLVFLSGFSLFEASQISKEIC 229

  Fly   446 DDNGTIMCPQCDRSCDYWRLNETCTSSKFNYLIDNNMTVVFAFSMAIWAVVYLEFWKRYSAGLVH 510
            :.:..:|||..|.|..|.||:||||.:|..:|.||:.|||||..||:||.|:||.|||..|.:|.
Human   230 EAHDILMCPLGDHSRRYQRLSETCTFAKLTHLFDNDGTVVFAIFMALWATVFLEIWKRQRARVVL 294

  Fly   511 RWGLTGFTHHVEHPRPQYLARISRTKKLAGKAYEQDHTGKRTILDPDVPFWSFKFLPNFTSY--- 572
            .|.|..:..                        ||:....:.|..||     :|..|...||
Human   295 HWDLYVWDE------------------------EQEEMALQLINCPD-----YKLRPYQHSYLRS 330

  Fly   573 ----SIMVLFICISVIAIAGIIIYRMAQRA---SHSILGSENSMTFKVMILPMTAGIIDLIVISL 630
                .:.:|.||:.:.....:::||:...|   |.::...|..:|..|::   |..::..:.|.:
Human   331 TVILVLTLLMICLMIGMAHVLVVYRVLASALFSSSAVPFLEEQVTTAVVV---TGALVHYVTIII 392

  Fly   631 LDMVYSNLAVKLTNYEYCRTQTEYDESLTIKNYVFQFVNYYSSLFYIAFLKGKFVGYPAKYNRVL 695
            :..:...:|:||.::|..||.:|.:...||:.:..||..::|||.||||:.|:..|:|.|..|:.
Human   393 MTKINRCVALKLCDFEMPRTFSERESRFTIRFFTLQFFTHFSSLIYIAFILGRINGHPGKSTRLA 457

  Fly   696 G-FRQEECNPGGCLMELCMQLVIIMAGKQAVNAIVEMLIPYLMRTFKELSYRHGWYKSHQDQRLV 759
            | ::.|||:..||:|:|.:|:.|||..||.::..||.|:|::....:.|......:.. :|..|
Human   458 GLWKLEECHASGCMMDLFVQMAIIMGLKQTLSNCVEYLVPWVTHKCRSLRASESGHLP-RDPEL- 520

  Fly   760 PYNQFTEDYNLLPAENNSLYVEYLEMVVQFGFITLFSLAFPLAPLLALLNNVIEVRLDAIKMLRF 824
              ..:..:|.|.|....||:.|::||::|:||.|:|..||||||||||.:|::|:|||||||:..
Human   521 --RDWRRNYLLNPVNTFSLFDEFMEMMIQYGFTTIFVAAFPLAPLLALFSNLVEIRLDAIKMVWL 583

  Fly   825 LRRPVGMRARDIGVWHSIMTVVTRIAVASSAMIIAFSTNLIPKIVY------AASMGDPE---LN 880
            .||.|..:|:|||.|..::..:..:||.::.|:|||::..||::||      ....|:..   |.
Human   584 QRRLVPRKAKDIGTWLQVLETIGVLAVIANGMVIAFTSEFIPRVVYKYRYSPCLKEGNSTVDCLK 648

  Fly   881 NYLNFTLAVFNTKDFQVQPLLGGSQHVNETVCRYTEFRNSPEDPHPYKRPMIYWKILTGRLAFIV 945
            .|:|.:|:||:|||||....:.||::|  |:|||.::||.|:    |.....:|.:|..||||::
Human   649 GYVNHSLSVFHTKDFQDPDGIEGSENV--TLCRYRDYRNPPD----YNFSEQFWFLLAIRLAFVI 707

  Fly   946 IYQNIITMLQGILRWAVPDVSGRLLKRIKRENFLLREHIIEYEKQHAMKLVQTELNGQQKSEG 1008
            :::::...::.|..|.|||:.    :.:|.:       ::|.:.|   :|.:...:|:|:..|
Human   708 LFEHVALCIKLIAAWFVPDIP----QSVKNK-------VLEVKYQ---RLREKMWHGRQRLGG 756

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10353	NP_001245633.1	Anoct_dimer	183..392	CDD:292796	45/205 (22%)
CG10353	NP_001245633.1	Anoctamin	395..977	CDD:282414	213/601 (35%)
ANO9	NP_001012302.2	Anoct_dimer	<115..176	CDD:292796	21/71 (30%)
		Anoctamin	179..735	CDD:282414	213/608 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	756..782		1/1 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2514
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1263362at2759
OrthoFinder	1	1.000	-	-		FOG0000156
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12308
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.920